Výsledky vyhledávání - "Vasanthi Bhaskaran"

Microphysiological Systems Evaluation: Experience of TEX-VAL Tissue Chip Testing Consortium

Autor: Ivan Rusyn, Courtney Sakolish, Yuki Kato, Clifford Stephan, Leoncio Vergara, Philip Hewitt, Vasanthi Bhaskaran, Myrtle Davis, Rhiannon N Hardwick, Stephen S Ferguson, Jason P Stanko, Piyush Bajaj, Karissa Adkins, Nisha S Sipes, E Sidney Hunter, Maria T Baltazar, Paul L Carmichael, Kritika Sadh, Richard A Becker

Publikováno v: Toxicol Sci

Much has been written and said about the promise and excitement of microphysiological systems, miniature devices that aim to recreate aspects of human physiology on a chip. The rapid explosion of the offerings and persistent publicity placed high exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5fe00b5247331ff1b276233e30fd420
https://pubmed.ncbi.nlm.nih.gov/35689632

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Mechanisms for Hepatobiliary Toxicity in Rats Treated with an Antagonist of Melanin Concentrating Hormone Receptor 1 (MCHR1)

Autor: Monicah A. Otieno, Evan B. Janovitz, Yimer Callejas, Lois D. Lehman-McKeeman, William B. Foster, Vasanthi Bhaskaran, William N. Washburn, John R. Megill, Brian Gemzik

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 155(2)

The objective of this work was to investigate the mechanisms of hepatobiliary toxicity caused by thienopyrimidone MCHR1 antagonists using BMS-773174 as a tool molecule. Co-administration of the pan CYP inhibitor 1-aminobenzotriazole with BMS-773174 p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7facdc273fb0b6f9e6fdab9eb059e2c
https://pubmed.ncbi.nlm.nih.gov/28025230

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Modulation of ascorbic acid metabolism by cytochrome P450 induction revealed by metabonomics and transcriptional profiling

Autor: Steve Stryker, Nelly Aranibar, Karl-Heinz Ott, Lei Gong, Vasanthi Bhaskaran, Jeffrey D. Vassallo, Lois D. Lehman-McKeeman, David M. Nelson, Lloyd Lecureux

Publikováno v: Magnetic Resonance in Chemistry. 47:S12-S19

In the present study, NMR-based urinary metabonomic profiles resulting from dosing with widely recognized microsomal enzyme inducers were evaluated in male rats. Wistar or Sprague–Dawley rats were dosed daily by oral gavage with phenobarbital (PB;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103f1166f0b31a90b175458f8629f387
https://doi.org/10.1002/mrc.2503

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p53-Independent Induction of Rat Hepatic Mdm2 following Administration of Phenobarbital and Pregnenolone 16α-Carbonitrile

Autor: Vasanthi Bhaskaran, Lois D. Lehman-McKeeman, William R. Foster, David M. Nelson

Publikováno v: Toxicological Sciences. 94:272-280

Murine double minute 2 (Mdm2) negatively regulates p53 by mediating its ubiquitination and proteosomal degradation, and Mdm2 is recognized as a proto-oncogene. In the present study, hepatic gene expression patterns induced by phenobarbital (PB; 100 m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1f8220829353e455b9775b72a3de88
https://doi.org/10.1093/toxsci/kfl115

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Unique Gene Expression and Hepatocellular Injury in the Lipopolysaccharide-Ranitidine Drug Idiosyncrasy Rat Model: Comparison with Famotidine

Autor: Jane F. Maddox, David M. Nelson, Patricia E. Ganey, Vasanthi Bhaskaran, Glenn H. Cantor, Robert A. Roth, Bruce D. Car, Lois D. Lehman-McKeeman, James P. Luyendyk, Timothy P. Reilly

Publikováno v: Toxicological Sciences. 90:569-585

Rats cotreated with lipopolysaccharide (LPS) and ranitidine (RAN) but not LPS and famotidine (FAM) develop hepatocellular injury in an animal model of idiosyncratic drug reactions. Evaluation of liver gene expression in rats given LPS and/or RAN led

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19da443d3956f5500206ef023f26fcd3
https://doi.org/10.1093/toxsci/kfj103

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Coagulation-Dependent Gene Expression and Liver Injury in Rats Given Lipopolysaccharide with Ranitidine but Not with Famotidine

Autor: Jane F. Maddox, David M. Nelson, Bruce D. Car, Lois D. Lehman-McKeeman, James P. Luyendyk, Timothy P. Reilly, Vasanthi Bhaskaran, Glenn H. Cantor, Patricia E. Ganey, Robert A. Roth, Xiaomin Deng

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 317:635-643

In an animal model of drug idiosyncrasy, rats cotreated with nonhepatotoxic doses of lipopolysaccharide (LPS) and ranitidine (RAN) develop hepatocellular injury, whereas rats treated with LPS and famotidine (FAM) do not. The coagulation system and ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b48a2270db44f025057cfdd9df6ab3
https://doi.org/10.1124/jpet.105.096305

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Characterization of organic anion-transporting polypeptide (Oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles

Autor: Yong-Hae Han, Nelly Aranibar, Lei L. Gong, Curtis D. Klaassen, Vasanthi Bhaskaran, Purnima Khandelwal, Youcai Zhang, Lloyd Lecureux, Lois D. Lehman-McKeeman

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 122(2)

Organic anion-transporting polypeptides (Oatp) 1a1 and 1a4 were deleted by homologous recombination, and mice were characterized for Oatp expression in liver and kidney, transport in isolated hepatocytes, in vivo disposition of substrates, and urinar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b23d0e0b251f55444d1ac4cf3568662
https://pubmed.ncbi.nlm.nih.gov/21561886

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Comparison of TNFα to Lipopolysaccharide as an Inflammagen to Characterize the Idiosyncratic Hepatotoxicity Potential of Drugs: Trovafloxacin as an Example

Autor: James P. Luyendyk, Amy C. Ditewig, Patricia E. Ganey, Eric A.G. Blomme, Lois D. Lehman-McKeeman, Robert A. Roth, Jeffrey F. Waring, Jane F. Maddox, Vasanthi Bhaskaran, David M. Nelson, Michael J. Liguori

Publikováno v: International Journal of Molecular Sciences
Volume 11
Issue 11
Pages 4697-4714
International Journal of Molecular Sciences, Vol 11, Iss 11, Pp 4697-4714 (2010)

Idiosyncratic drug reactions (IDRs) are poorly understood, unpredictable, and not detected in preclinical studies. Although the cause of these reactions is likely multi-factorial, one hypothesis is that an underlying inflammatory state lowers the tol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a087ab1c9e803430c9c9157390519028

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A retrospective analysis of toxicogenomics in the safety assessment of drug candidates

Autor: Amy Truong, Lois D. Lehman-McKeeman, Vasanthi Bhaskaran, Bruce D. Car, Aiqing He, William R. Foster, Shen-Jue Chen, David M. Nelson, Donna M. Dambach

Publikováno v: Toxicologic pathology. 35(5)

Toxicogenomics is considered a valuable tool for reducing pharmaceutical candidate attrition by facilitating earlier identification, prediction and understanding of toxicities. A retrospective evaluation of 3 years of routine transcriptional profilin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff83a70d1e4d088ef110b54a94721df
https://pubmed.ncbi.nlm.nih.gov/17654404

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