Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Vasanthakumar Rajappan"'
Publikováno v:
Nucleosides and Nucleotides. 17:1141-1151
Synthesis and biochemical screening against guanase of analogues of the naturally occurring guanase inhibitor azepinomycin (2) are reported. Compound e-amino-5,6,7,8,-tetrahydro-4H-imidazo[4,5-e][1,4]diazepine-5,8-dione (3) was synthesized in six ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a760100be00e85a95ed81de663900c7f
https://doi.org/10.1080/07328319808004227
https://doi.org/10.1080/07328319808004227
Publikováno v:
Synthetic Communications. 28:753-764
The use of pentafluorophenol as a superior reagent for heterocyclic condensations, where other traditional condensing agents such as DCC and CDI failed, has been demonstrated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::224077c45296653780b5b7523f2da19f
https://doi.org/10.1080/00397919808005949
https://doi.org/10.1080/00397919808005949
Publikováno v:
ChemInform. 29
The use of pentafluorophenol as a superior reagent for heterocyclic condensations, where other traditional condensing agents such as DCC and CDI failed, has been demonstrated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b65955e0aa588d99c7fa98fc4d7dd0c9
https://doi.org/10.1002/chin.199826058
https://doi.org/10.1002/chin.199826058
Autor:
Patrick Fagan, Jennifer L. Brooks, Tiffany Hurd, Vasanthakumar Rajappan, Nicholas A. Boyle, P. Dan Cook, Marija Prhavc, Yi Jin, Thomas W. Bruice, Fu Chen, Vivek K. Rajwanshi, Janet M Leeds, Guangyi Wang
Publikováno v:
Journal of medicinal chemistry. 47(27)
In search of active nucleoside 5'-triphosphate mimics, we have synthesized a series of AZT triphosphate mimics (AZT P3Ms) and evaluated their inhibitory effects on HIV-1 reverse transcriptase as well as their stability in fetal calf serum and in CEM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d5fa371fcce03fc76df869cb83e25b
https://pubmed.ncbi.nlm.nih.gov/15615539
https://pubmed.ncbi.nlm.nih.gov/15615539
Autor:
Patrick Fagan, Kandasamy Sakthivel, Tiffany Hurd, Janet M. Leeds, Vasanthakumar Rajappan, Kathleen D. Tucker, Jennifer L. Brooks, Guangyi Wang, P. Dan Cook, Thomas W. Bruice
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 23(1-2)
IMPDH inhibitors have potential antimicrobial, anticancer and immunomodulatory effects. Nucleoside inhibitors of IMPDH exert their inhibitory effects via nucleoside 5′‐MPs. Conversion of nucleoside analogs to NMPs by cellular nucleoside kinases i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b5a6b59e253f6e8dfdbc415b2b85e2
https://pubmed.ncbi.nlm.nih.gov/15043157
https://pubmed.ncbi.nlm.nih.gov/15043157
Publikováno v:
ChemInform. 34
A facile synthesis of (−)-(4R,5R)-4,5-(isopropylidenedioxy)-2-cyclopentenone ((−)-2), as a precursor to d-like carbanucleosides, is described in 5 steps from (1S,4R)-4-acetoxycyclopent-2-en-1-ol (3). Compound 3 has also been described in the lite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8bab17df7a5d897d12ea592b73faed9
https://doi.org/10.1002/chin.200335170
https://doi.org/10.1002/chin.200335170
Publikováno v:
Nucleosidesnucleotides. 18(4-5)
In an effort to explore the biochemical mode of guanase inhibition as well as the structure-activity relationships of azepinomycin, five analogues (I-V) of azepinomycin were synthesized and screened against guanase from rabbit liver. Our results sugg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe406fe97b5ff2f3812247d4861eed7
https://pubmed.ncbi.nlm.nih.gov/10432688
https://pubmed.ncbi.nlm.nih.gov/10432688
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(24)
The synthesis of a novel planar, potentially aromatic, ring-expanded xanthine analogue ( 1 ), containing the 5:7-fused imidazo[4,5-e][1,4]diazepine ring system, along with guanase inhibition studies are reported. The compound was synthesized in six s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1207b915e043a9161286ccdb724bba8c
https://pubmed.ncbi.nlm.nih.gov/9934488
https://pubmed.ncbi.nlm.nih.gov/9934488