Zobrazeno 1 - 10
of 259
pro vyhledávání: '"Vasantha L"'
Autor:
Shanta Murthy, Murugadas Anbazhagan, Sushma Chowdary Maddipatla, Vasantha L. Kolachala, Anne Dodd, Ranjit Pelia, David J. Cutler, Jason D. Matthews, Subra Kugathasan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Perianal fistulizing Crohn’s disease (CD) is a severe gastrointestinal disorder causing extensive mucosal damage with limited treatment options. Severe manifestations of the disease appear at higher rates in non-Europeans but the genetic a
Externí odkaz:
https://doaj.org/article/9e986aae16f04da0b37b685264521a99
PTGER4 signaling regulates class IIa HDAC function and SPINK4 mRNA levels in rectal epithelial cells
Autor:
Murugadas Anbazhagan, Garima Sharma, Shanta Murthy, Sushma Chowdary Maddipatla, Vasantha L. Kolachala, Anne Dodd, Amanda Randunne, David J. Cutler, Subra Kugathasan, Jason D. Matthews
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background The prostaglandin receptor PTGER4 facilitates homeostasis in the gut. Previous reports indicate that goblet cells, marked by SPINK4 expression, might be affected by PTGER4 activity. Current evidence suggests that prostaglandin E2
Externí odkaz:
https://doaj.org/article/703b6ce950e24a41929fb944510436e4
Autor:
Vasantha L. Kolachala, Chungwen Wei, Suresh Venkateswaran, Aisha Latrece Hill, Vivian Warren, Hillary Espinoza, Iñaki Sanz, Nitika A. Gupta
Publikováno v:
Autoimmunity, Vol 57, Iss 1 (2024)
AbstractAutoimmune hepatitis (AIH) is a chronic, inflammatory liver disease of unknown aetiology which requires lifelong immunosuppression. Most therapeutic and outcome studies of AIH have been conducted predominantly in Caucasian (European Ancestry,
Externí odkaz:
https://doaj.org/article/852b7a5bfa20480ba878c875a2d95032
Autor:
Savannah Washburn, Sushma C. Maddipatla, Shanta Murthy, Anne Dodd, Ranjit S. Pelia, Vasantha L. Kolachala, Duke Geem, Jason D. Matthews, Greg Gibson, Subra Kugathasan
Publikováno v:
Gastro Hep Advances, Vol 3, Iss 1, Pp 131-133 (2024)
Externí odkaz:
https://doaj.org/article/96f777f86aa246ff991fdc1a1c2d227a
Autor:
Lynda J. Krasenbaum, Vasantha L. Pedarla, Stephen F. Thompson, Krishna Tangirala, Joshua M. Cohen, Maurice T. Driessen
Publikováno v:
The Journal of Headache and Pain, Vol 23, Iss 1, Pp 1-10 (2022)
Abstract Background Following approval of fremanezumab for the prevention of migraine in adults, health care decision makers are interested in understanding real-world clinical characteristics and treatment patterns among patients initiating fremanez
Externí odkaz:
https://doaj.org/article/62fa09b7fa36471dad994913a5d193fd
Autor:
Barbara Joanna Niklinska-Schirtz, Suresh Venkateswaran, Murugadas Anbazhagan, Vasantha L. Kolachala, Jarod Prince, Anne Dodd, Raghavan Chinnadurai, Gregory Gibson, Lee A. Denson, David J. Cutler, Anil G. Jegga, Jason D. Matthews, Subra Kugathasan
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1267-1280 (2021)
Background & Aims: We used patient-derived organoids (PDOs) to study the epithelial-specific transcriptional and secretome signatures of the ileum during Crohn’s disease (CD) with varying phenotypes to screen for disease profiles and potential drug
Externí odkaz:
https://doaj.org/article/138e1bb610ec4c1a92016aaad7d4e59a
Autor:
Timothy Hadley, Scott Gillespie, Hillary Espinoza, Jarod Prince, Henning Gronbaek, Shanmuganathan Chandrakasan, Subra Kuguthasan, Vasantha L. Kolachala, Nitika A. Gupta
Publikováno v:
Autoimmunity, Vol 53, Iss 5, Pp 253-260 (2020)
Introduction: Immune mediated liver diseases entail a broad category which are associated with increased morbidity and mortality amongst the paediatric population. Programmed Death 1 (PD1) is an inhibitory receptor mainly expressed by T cells, and wh
Externí odkaz:
https://doaj.org/article/b193a9c1f145478d89f0efc3f5dbc7dd
Autor:
Vasantha L. Kolachala, Sirish K. Palle, Ming Shen, Asha Shenoi, Dmitry M. Shayakhmetov, Nitika A. Gupta
Publikováno v:
Hepatology Communications, Vol 3, Iss 7, Pp 925-942 (2019)
Current understanding is that receptor interacting serine/threonine protein kinase 1 (RIPK1) can lead to two distinct forms of cell death: RIPK3‐mediated necroptosis or caspase 8 (Casp8)‐mediated apoptosis. Here, we report that RIPK1 signaling is
Externí odkaz:
https://doaj.org/article/2da3cb6dbc564721b496494ebfded41f
Autor:
Bao, Shunxing, Zhu, Sichen, Kolachala, Vasantha L, Remedios, Lucas W., Hwang, Yeonjoo, Sun, Yutong, Deng, Ruining, Cui, Can, Li, Yike, Li, Jia, Roland, Joseph T., Liu, Qi, Lau, Ken S., Kugathasan, Subra, Qiu, Peng, Wilson, Keith T., Coburn, Lori A., Landman, Bennett A., Huo, Yuankai
Crohn's disease (CD) is a chronic and relapsing inflammatory condition that affects segments of the gastrointestinal tract. CD activity is determined by histological findings, particularly the density of neutrophils observed on Hematoxylin and Eosin
Externí odkaz:
http://arxiv.org/abs/2308.10166
Autor:
Kolachala, Vasantha L.1, Chungwen Wei2,3,4, Venkateswaran, Suresh1, Hill, Aisha Latrece2,3,4, Warren, Vivian2,3,4, Espinoza, Hillary1, Sanz, Iñaki2,3,4, Gupta, Nitika A.1,5 nitika.gupta@emory.edu
Publikováno v:
Autoimmunity. Dec2024, Vol. 57 Issue 1, p1-6. 6p.