Chemical modulation of cytosolic BAX homodimer potentiates BAX activation and apoptosis

Autor: Nadege Gitego, Bogos Agianian, Oi Wei Mak, Vasantha Kumar MV, Emily H. Cheng, Evripidis Gavathiotis

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)

Abstract The BCL-2 family protein BAX is a major regulator of physiological and pathological cell death. BAX predominantly resides in the cytosol in a quiescent state and upon stress, it undergoes conformational activation and mitochondrial transloca

Externí odkaz: https://doaj.org/article/887f3cce28c94c2a981f814af8621aef

Molecular insights into the interaction of Hsp90 with allosteric inhibitors targeting the C-terminal domain

Autor: Brian S. J. Blagg, Zheng Zhang, Ioannis Gelis, Edvinas Sipavicius, Rachel E. Davis, Radwan Ebna Noor, Vasantha Kumar Mv, Dimitra Keramisanou

Publikováno v: MedChemComm. 9:1323-1331

Unique to targeting the C-terminal domain of Hsp90 (C-Hsp90) is the ability to uncouple the cytotoxic and cytoprotective outcomes of Hsp90 modulation. After the identification of novobiocin as a C-Hsp90 interacting ligand a diverse gamut of novologue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10fcf024f772e66a14f5bb5802368a92
https://doi.org/10.1039/c8md00151k

Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation.

Autor: Bachman AB; Department of Chemistry, University of South Florida, Tampa, FL, 33620, USA., Keramisanou D; Department of Chemistry, University of South Florida, Tampa, FL, 33620, USA., Xu W; Urologic Oncology Branch, National Cancer Institute, Bethesda, MD, 20892, USA., Beebe K; Urologic Oncology Branch, National Cancer Institute, Bethesda, MD, 20892, USA., Moses MA; Urologic Oncology Branch, National Cancer Institute, Bethesda, MD, 20892, USA., Vasantha Kumar MV; Department of Chemistry, University of South Florida, Tampa, FL, 33620, USA., Gray G; Department of Chemistry, University of South Florida, Tampa, FL, 33620, USA., Noor RE; Department of Chemistry, University of South Florida, Tampa, FL, 33620, USA., van der Vaart A; Department of Chemistry, University of South Florida, Tampa, FL, 33620, USA., Neckers L; Urologic Oncology Branch, National Cancer Institute, Bethesda, MD, 20892, USA., Gelis I; Department of Chemistry, University of South Florida, Tampa, FL, 33620, USA. igelis@usf.edu.

Publikováno v: Nature communications [Nat Commun] 2018 Jan 17; Vol. 9 (1), pp. 265. Date of Electronic Publication: 2018 Jan 17.

N-H...F hydrogen bonds in fluorinated benzanilides: NMR and DFT study.

Autor: Manjunatha Reddy GN; NMR Research Centre, Indian Institute of Science, Bangalore 560012, India., Vasantha Kumar MV, Guru Row TN, Suryaprakash N

Publikováno v: Physical chemistry chemical physics : PCCP [Phys Chem Chem Phys] 2010 Oct 28; Vol. 12 (40), pp. 13232-7. Date of Electronic Publication: 2010 Sep 06.