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Epigenetic regulators of clonal hematopoiesis control CD8 T cell stemness during immunotherapy.

Autor: Tae Gun Kang, Xin Lan, Tian Mi, Hongfeng Chen, Alli, Shanta, Song-Eun Lim, Bhatara, Sheetal, Vasandan, Anoop Babu, Ward, Grace, Bentivegna, Sofia, Jang, Josh, Spatz, Marianne L., Jin-Hwan Han, Schlotmann, Balthasar Clemens, Jespersen, Jakob Schmidt, Derenzo, Christopher, Vogel, Peter, Jiyang Yu, Baylin, Stephen, Jones, Peter

Publikováno v: Science; 10/11/2024, Vol. 386 Issue 6718, p165-165, 1p, 1 Diagram

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Human Mesenchymal stem cells program macrophage plasticity by altering their metabolic status via a PGE2-dependent mechanism.

Autor: Vasandan, Anoop Babu¹, Jahnavi, Sowmya¹, Shashank, Chandanala¹, Prasad, Priya¹, Kumar, Anujith¹, Prasanna, S. Jyothi¹

Publikováno v: Scientific Reports. 12/2/2016, p38308. 1p.

Epigenetic regulators of clonal hematopoiesis control CD8 T cell stemness during immunotherapy.

Autor: Kang TG; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Lan X; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, TN 38105, USA., Mi T; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Chen H; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Alli S; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Lim SE; College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, TN 38105, USA.; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Bhatara S; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Vasandan AB; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Ward G; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Bentivegna S; Department of Hematology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.; Biotech Research and Innovation Center (BRIC), University of Copenhagen, DK-2200 Copenhagen, Denmark., Jang J; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., Spatz ML; Merck & Co. Inc., Rahway, NJ 07065, USA., Han JH; Merck & Co. Inc., Rahway, NJ 07065, USA., Schlotmann BC; The Finsen Laboratory, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark., Jespersen JS; Biotech Research and Innovation Center (BRIC), University of Copenhagen, DK-2200 Copenhagen, Denmark., Derenzo C; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Vogel P; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Yu J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Baylin S; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Institute at Johns Hopkins, Baltimore, MD 21231, USA., Jones P; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., O'Connell C; Jane Anne Nohl Division of Hematology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Grønbæk K; Department of Hematology, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark.; Biotech Research and Innovation Center (BRIC), University of Copenhagen, DK-2200 Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark., Youngblood B; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Zebley CC; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2024 Oct 11; Vol. 386 (6718), pp. eadl4492. Date of Electronic Publication: 2024 Oct 11.