Phase I Clinical Evaluation of Designed Ankyrin Repeat Protein [ 99m Tc]Tc(CO) 3 -(HE) 3 -Ec1 for Visualization of EpCAM-Expressing Lung Cancer.

Autor: Zelchan, Roman, Chernov, Vladimir, Medvedeva, Anna, Rybina, Anastasia, Bragina, Olga, Mishina, Elizaveta, Larkina, Mariia, Varvashenya, Ruslan, Fominykh, Anastasia, Schulga, Alexey, Konovalova, Elena, Vorobyeva, Anzhelika, Orlova, Anna, Tashireva, Liubov, Deyev, Sergey M., Tolmachev, Vladimir

Publikováno v: Cancers; Aug2024, Vol. 16 Issue 16, p2815, 12p

Comparative Preclinical Evaluation of HYNIC-Modified Designed Ankyrin Repeat Proteins G3 for the ^99mTc-Based Imaging of HER2-Expressing Malignant Tumors.

Autor: Larkina, Maria, Varvashenya, Ruslan, Yuldasheva, Feruza, Plotnikov, Evgenii, Bezverkhniaia, Ekaterina, Tretyakova, Maria, Zelchan, Roman, Schulga, Alexey, Konovalova, Elena, Vorobyeva, Anzhelika, Belousov, Mikhail, Orlova, Anna, Tolmachev, Vladimir, Deyev, Sergey

Publikováno v: Molecular Pharmaceutics; 2024, Vol. 21 Issue 4, p1919-1932, 14p

Comparative Preclinical Evaluation of HYNIC-Modified Designed Ankyrin Repeat Proteins G3 for the ^99m Tc-Based Imaging of HER2-Expressing Malignant Tumors.

Autor: Larkina M; Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia.; Department of Pharmaceutical Analysis, Siberian State Medical University, 634050 Tomsk, Russia., Varvashenya R; Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia.; Department of Pharmaceutical Analysis, Siberian State Medical University, 634050 Tomsk, Russia., Yuldasheva F; Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia., Plotnikov E; Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia., Bezverkhniaia E; Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia., Tretyakova M; Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia., Zelchan R; Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia.; Department of Nuclear Medicine, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634009 Tomsk, Russia., Schulga A; Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia.; Molecular Immunology Laboratory, Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia., Konovalova E; Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia.; Molecular Immunology Laboratory, Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia., Vorobyeva A; Department of Medicinal Chemistry, Uppsala University, 751 23 Uppsala, Sweden., Belousov M; Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia.; Department of Pharmaceutical Analysis, Siberian State Medical University, 634050 Tomsk, Russia., Orlova A; Department of Medicinal Chemistry, Uppsala University, 751 23 Uppsala, Sweden., Tolmachev V; Department of Immunology, Genetics and Pathology, Uppsala University, 75185 Uppsala, Sweden., Deyev S; Research Centrum for Oncotheranostics, Research School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, 634050 Tomsk, Russia.; Molecular Immunology Laboratory, Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.

Publikováno v: Molecular pharmaceutics [Mol Pharm] 2024 Apr 01; Vol. 21 (4), pp. 1919-1932.