Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Varun V. Gadkari"'
Autor:
Rishav Mitra, Varun V. Gadkari, Ben A. Meinen, Carlo P. M. van Mierlo, Brandon T. Ruotolo, James C. A. Bardwell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Spy is an ATP independent chaperone that can act as both a holdase and a foldase towards topologically simple substrates. Assessing the interaction of Spy and apoflavodoxin, a complex client, the authors show that Spy’s activity is substrate specif
Externí odkaz:
https://doaj.org/article/faf6241cffc94273ba8452b252a93b6d
Autor:
Jessica J. Waninger, Tyler S. Beyett, Varun V. Gadkari, Ronald F. Siebenaler, Carson Kenum, Sunita Shankar, Brandon T. Ruotolo, Arul M. Chinnaiyan, John J.G. Tesmer
Publikováno v:
Biochemistry and Biophysics Reports, Vol 29, Iss , Pp 101191- (2022)
Oncogenic mutations in KRAS result in a constitutively active, GTP-bound form that in turn activates many proliferative pathways. However, because of its compact and simple architecture, directly targeting KRAS with small molecule drugs has been chal
Externí odkaz:
https://doaj.org/article/5afdc55c4e9a499fb8675d06a6b666e1
Autor:
Varun V. Gadkari, Brock R. Juliano, Christopher S. Mallis, Jody C. May, Ruwan T. Kurulugama, John C. Fjeldsted, John A. McLean, David H. Russell, Brandon T. Ruotolo
Publikováno v:
The Analyst.
Native ion mobility-mass spectrometry (IM-MS) has emerged as an information-rich technique for gas phase protein structure characterization; however, IM resolution is currently insufficient for the detection of subtle structural differences in large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1d8fb7db0947c02bb5a6ce4e59c3069
https://pubmed.ncbi.nlm.nih.gov/36537590
https://pubmed.ncbi.nlm.nih.gov/36537590
Autor:
Daniel D. Vallejo, Carolina Rojas Ramírez, Kristine F. Parson, Yilin Han, Varun V. Gadkari, Brandon T. Ruotolo
Publikováno v:
Chem Rev
Mass spectrometry is a central technology in the life sciences, providing our most comprehensive account of the molecular inventory of the cell. In parallel with developments in mass spectrometry technologies targeting such assessments of cellular co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0259615a9ca36bb34f37325f265aa6c4
https://pubmed.ncbi.nlm.nih.gov/35316030
https://pubmed.ncbi.nlm.nih.gov/35316030
Autor:
Sugyan M. Dixit, Daniel A. Polasky, Varun V. Gadkari, Michael F. Keating, Brandon T. Ruotolo, Philip C. Andrews
Publikováno v:
Journal of the American Chemical Society. 142:6750-6760
Post-translational modifications create a diverse mixture of proteoforms, leading to substantial challenges in linking proteomic information to disease. Top-down sequencing of intact proteins and multiprotein complexes offers significant advantages i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d4d8dac05c79e48758a0e246fe8b0d
https://doi.org/10.1021/jacs.0c01076
https://doi.org/10.1021/jacs.0c01076
Publikováno v:
Proceedings of the National Academy of Sciences. 116:23040-23049
The assembly of small disordered proteins into highly ordered amyloid fibrils in Alzheimer’s and Parkinson’s patients is closely associated with dementia and neurodegeneration. Understanding the process of amyloid formation is thus crucial in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005700fe77f4427cb3f1a22d8307a3b2
https://doi.org/10.1073/pnas.1913316116
https://doi.org/10.1073/pnas.1913316116
Autor:
Ben A. Meinen, Varun V. Gadkari, Rishav Mitra, Brandon T. Ruotolo, Carlo P. M. van Mierlo, James C.A. Bardwell
Publikováno v:
Nature Communications, 12(1)
Nature Communications
Nature Communications 12 (2021) 1
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications 12 (2021) 1
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
ATP-independent chaperones are usually considered to be holdases that rapidly bind to non-native states of substrate proteins and prevent their aggregation. These chaperones are thought to release their substrate proteins prior to their folding. Spy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce05126cac073c908f08276a5a1f68c7
https://research.wur.nl/en/publications/mechanism-of-the-small-atp-independent-chaperone-spy-is-substrate
https://research.wur.nl/en/publications/mechanism-of-the-small-atp-independent-chaperone-spy-is-substrate
Autor:
Ruwan T. Kurulugama, Daniel D. Vallejo, Varun V. Gadkari, Brandon T. Ruotolo, Carolina Rojas Ramírez, John C. Fjeldsted
Publikováno v:
Anal Chem
Native ion mobility-mass spectrometry (IM-MS) is capable of revealing much that remains unknown within the structural proteome, promising such information on refractory protein targets. Here, we report the development of a unique drift tube IM-MS (DT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d7ef48ad42c1779a6c06860cbd75505
https://pubmed.ncbi.nlm.nih.gov/33166123
https://pubmed.ncbi.nlm.nih.gov/33166123
Autor:
Vicki H. Wysocki, Jin Wang, Austin T. Raper, Zucai Suo, Sophie R. Harvey, Varun V. Gadkari, Wen-Ting Chu
Publikováno v:
Nucleic Acids Research
Proliferating cell nuclear antigen (PCNA) is a trimeric ring-shaped clamp protein that encircles DNA and interacts with many proteins involved in DNA replication and repair. Despite extensive structural work to characterize the monomeric, dimeric, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126c285be9fb3899a2419153672632ad
http://europepmc.org/articles/PMC5888646
http://europepmc.org/articles/PMC5888646
Publikováno v:
Chemical Research in Toxicology. 30:260-269
Innovative advances in X-ray crystallography and single-molecule biophysics have yielded unprecedented insight into the mechanisms of DNA lesion bypass and damage repair. Time-dependent X-ray crystallography has been successfully applied to view the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c18cef0cb85141b9c9b730e27448490
https://doi.org/10.1021/acs.chemrestox.6b00342
https://doi.org/10.1021/acs.chemrestox.6b00342