Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Varun Sasidharan Nair"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Previously, we reported an anti-inflammatory effect of mTORC1 in a mouse model of type 2 skin inflammation. TSLP, one of the epithelial cell-derived cytokines, was upregulated by Raptor deficiency or rapamycin treatment, which was inhibited by dimeth
Externí odkaz:
https://doaj.org/article/ff9df57fe35a4422a48190f6dff2ebfd
Autor:
Pramod Darvin, Varun Sasidharan Nair
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/87de73a74a02491fba323ce03ec103f7
Publikováno v:
Epigenetics, Vol 15, Iss 12, Pp 1275-1288 (2020)
Myeloid cells, including antigen-presenting cells (APCs) and myeloid-derived suppressor cells (MDSCs) play opposing roles to orchestrate innate and adaptive immune responses during physiological and pathological conditions. We investigated the role o
Externí odkaz:
https://doaj.org/article/4c40685c412d4c408176ec25a561463d
Publikováno v:
Experimental and Molecular Medicine, Vol 50, Iss 12, Pp 1-11 (2018)
Cancer immunotherapy: Markers of success Biomarkers that predict a patient’s response to cancer immunotherapy are being developed, and may allow individual tailoring of therapies. Cancer cells can suppress the immune system by activating immune che
Externí odkaz:
https://doaj.org/article/02cbef34102b4e70b2092a2f86e732c4
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 137, Iss , Pp 111351- (2021)
Circular RNAs (circRNAs) are a class of endogenous noncoding RNA, which were previously considered as a byproduct of RNA splicing error. Numerous studies have demonstrated the altered expression of circRNAs in organ tissues during pathological condit
Externí odkaz:
https://doaj.org/article/52e1f59391184ca0bc2c08c8f30a2526
Autor:
Reem Saleh, Varun Sasidharan Nair, Mahmood Al-Dhaheri, Mahwish Khawar, Mohamed Abu Nada, Nehad M. Alajez, Eyad Elkord
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Elevated levels of myeloid-derived suppressor cells (MDSCs), including polymorphonuclear MDSCs (PMN-MDSCs) and immature MDSCs (I-MDSCs), are usually associated with disease progression in cancer patients, including colorectal cancer (CRC). However, b
Externí odkaz:
https://doaj.org/article/30040a56eb4e48059038cabcfe1cd730
Autor:
Reem Saleh, Varun Sasidharan Nair, Salman M Toor, Rowaida Z Taha, Khaled Murshed, Mahmood Al-Dhaheri, Mahwish Khawar, Mahir Abdulla Petkar, Mohamed Abu Nada, Fares Al-Ejeh, Eyad Elkord
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Cytotoxic CD8+ T cell-mediated response is the most important arm of adaptive immunity, which dictates the capacity of the host immune response in eradicating tumor cells. Due to tumor intrinsic and/or extrinsic factors, the density and fu
Externí odkaz:
https://doaj.org/article/afa644e3548e42fc8e8cc33170031fcc
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Myeloid-derived suppressor cells (MDSCs) promote tumor immune evasion and favor tumorigenesis by activating various tumor-promoting downstream signals. MDSC expansion is evident in the circulation and tumor microenvironment of many solid tumors inclu
Externí odkaz:
https://doaj.org/article/618130fe86a2473788dccc50e3ee0e27
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
A balance between co-inhibitory and co-stimulatory signals in the tumor microenvironment (TME) is critical to suppress tumor development and progression, primarily via maintaining effective immunosurveillance. Aberrant expression of immune checkpoint
Externí odkaz:
https://doaj.org/article/ee4761e96bff449fae3d8fdcdca11611
Autor:
Varun Sasidharan Nair, Reem Saleh, Rowaida Z Taha, Salman M Toor, Khaled Murshed, Ayman A Ahmed, Mohamed A Kurer, Mohamed Abu Nada, Fares Al Ejeh, Eyad Elkord
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Tumor-infiltrating lymphocytes (TILs) play indispensable roles in the progression and response to treatment of solid tumors. However, the prognostic significance of CD4+ TILs is not fully disclosed in cancers generally and in CRC in particular, mainl
Externí odkaz:
https://doaj.org/article/092a81680cdd4504943850554fd86e3e