Testosterone is an endogenous regulator of BAFF and splenic B cell number

Autor: Anna S. Wilhelmson, Marta Lantero Rodriguez, Alexandra Stubelius, Per Fogelstrand, Inger Johansson, Matthew B. Buechler, Steve Lianoglou, Varun N. Kapoor, Maria E. Johansson, Johan B. Fagman, Amanda Duhlin, Prabhanshu Tripathi, Alessandro Camponeschi, Bo T. Porse, Antonius G. Rolink, Hans Nissbrandt, Shannon J. Turley, Hans Carlsten, Inga-Lill Mårtensson, Mikael C. I. Karlsson, Åsa Tivesten

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Testosterone deficiency is associated with autoimmunity and increased B cell numbers, but the underlying mechanism is unclear. Here the authors show that testosterone may modulate the production of B cell survival factor BAFF by fibroblastic reticula

Externí odkaz: https://doaj.org/article/d1f804563c204b959332c0cb6ac7f78d

Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues

Autor: Alessandra Castiglioni, Markus Brown, Jillian L. Astarita, Mark Z. Chen, Lucinda Tam, Richard Bourgon, Claudia X. Dominguez, Shilpa Keerthivasan, Cecile Chalouni, Wendy Sandoval, Viviana Cremasco, Xiumin Wu, Yeqing Angela Yang, Andrey S. Shaw, Frederic J. de Sauvage, Ira Mellman, Elaine E. Storm, Catherine B Carbone, Merone Roose-Girma, Zora Modrusan, Amber W. Wang, Akshay T. Krishnamurty, Yasin Senbabaoglu, Wyne P. Lee, Jonas Doerr, Maximilian Nitschké, Shannon J. Turley, Varun N. Kapoor, Ryan Lane, Sören Müller, Christine Moussion

Publikováno v: Nature Immunology. 22:571-585

Fibroblastic reticular cells (FRCs) are specialized stromal cells that define tissue architecture and regulate lymphocyte compartmentalization, homeostasis, and innate and adaptive immunity in secondary lymphoid organs (SLOs). In the present study, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2383e3a737dd8c2478d0ddc2038bf224
https://doi.org/10.1038/s41590-021-00920-6

IL-1R1–dependent signaling coordinates epithelial regeneration in response to intestinal damage

Autor: David L. Lin, Varun N. Kapoor, Naruhisa Ota, Joseph Chavarria-Smith, Christian Cox, Menno van Lookeren Campagne, Travis W. Bainbridge, Noelyn M. Kljavin, Keith R. Anderson, Joseph R. Arron, Frederic J. de Sauvage, Shannon J. Turley, Yun Li, Søren Warming, Elaine E. Storm, Lifen Wang, Merone Roose-Girma

Publikováno v: Science Immunology. 6

Repair of the intestinal epithelium is tightly regulated to maintain homeostasis. The response after epithelial damage needs to be local and proportional to the insult. How different types of damage are coupled to repair remains incompletely understo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1162144f6b64db655704fd331d14d76a
https://doi.org/10.1126/sciimmunol.abe8856

Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient

Autor: Assieh Saadatpour, Shariq Madha, Liam T. Gaynor, Christian Cox, Elisa Manieri, Frederic J. de Sauvage, Adrienne M. Luoma, Shilpa Keerthivasan, Kai W. Wucherpfennig, Ramesh A. Shivdasani, Varun N. Kapoor, Shannon J. Turley, Elaine E. Storm, Guo-Cheng Yuan, Neil McCarthy

Publikováno v: Cell Stem Cell

Summary Intestinal stem cells (ISCs) are confined to crypt bottoms and their progeny differentiate near crypt-villus junctions. Wnt and bone morphogenic protein (BMP) gradients drive this polarity, and colorectal cancer fundamentally reflects disrupt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c433b9e0003149c3e3bc03e74e08904e
https://pubmed.ncbi.nlm.nih.gov/32084389

Testosterone is an endogenous regulator of BAFF and splenic B cell number

Autor: Hans Carlsten, Amanda Duhlin, Prabhanshu Tripathi, Alessandro Camponeschi, Mikael C. I. Karlsson, Maria E. Johansson, Steve Lianoglou, Per Fogelstrand, Alexandra Stubelius, Åsa Tivesten, Inger Johansson, Varun N. Kapoor, Johan Bourghardt Fagman, Anna S. Wilhelmson, Hans Nissbrandt, Matthew B. Buechler, Shannon J. Turley, Bo T. Porse, Inga-Lill Mårtensson, Antonius G. Rolink, Marta Lantero Rodriguez

Publikováno v: Nature Communications
Wilhelmson, A S, Lantero Rodriguez, M, Stubelius, A, Fogelstrand, P, Johansson, I, Buechler, M B, Lianoglou, S, Kapoor, V N, Johansson, M E, Fagman, J B, Duhlin, A, Tripathi, P, Camponeschi, A, Porse, B T, Rolink, A G, Nissbrandt, H, Turley, S J, Carlsten, H, Mårtensson, I-L, Karlsson, M C I & Tivesten, Å 2018, ' Testosterone is an endogenous regulator of BAFF and splenic B cell number ', Nature Communications, vol. 9, 2067, pp. 1-13 . https://doi.org/10.1038/s41467-018-04408-0
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Testosterone deficiency in men is associated with increased risk for autoimmunity and increased B cell numbers through unknown mechanisms. Here we show that testosterone regulates the cytokine BAFF, an essential survival factor for B cells. Male mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84c447a10aeadf117544609da6f5bd04
http://europepmc.org/articles/PMC5970247