Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Varun Kamat"'
Autor:
Varun Kamat, Ian R. Sweet
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionBiphasic insulin secretion is an intrinsic characteristic of the pancreatic islet and has clinical relevance due to the loss of first-phase in patients with Type 2 diabetes. As it has long been shown that first-phase insulin secretion onl
Externí odkaz:
https://doaj.org/article/6fc9e053f75841c9ba246fcaee20d33b
Autor:
Kylie S. Chichura, Clinton T. Elfers, Therese S. Salameh, Varun Kamat, Oleg G. Chepurny, Aelish McGivney, Brandon T. Milliken, George G. Holz, Sarah V. Applebey, Matthew R. Hayes, Ian R. Sweet, Christian L. Roth, Robert P. Doyle
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Mechanisms underlying long-term sustained weight loss and glycemic normalization after obesity surgery include changes in gut hormone levels, including glucagon-like peptide 1 (GLP-1) and peptide YY (PYY). We demonstrate that two peptide bia
Externí odkaz:
https://doaj.org/article/dc106d853e6f471fa38cee689f96ea30
Autor:
Varun Kamat, Matthew K. Grumbine, Khang Bao, Kedar Mokate, Gamal Khalil, Daniel Cook, Brandon Clearwater, Richard Hirst, Jarrod Harman, Myriam Boeck, Zhongjie Fu, Lois E.H. Smith, Moloy Goswami, Thomas J. Wubben, Emily M. Walker, Jie Zhu, Scott A. Soleimanpour, Jarrad M. Scarlett, Brian M. Robbings, Daniel Hass, James B. Hurley, Ian R. Sweet
Publikováno v:
Cell Reports: Methods, Vol 3, Iss 11, Pp 100642- (2023)
Summary: To address the needs of the life sciences community and the pharmaceutical industry in pre-clinical drug development to both maintain and continuously assess tissue metabolism and function with simple and rapid systems, we improved on the in
Externí odkaz:
https://doaj.org/article/3224701920bf49ea8c3bff2c8370db61
Autor:
Varun Kamat, Brian M Robbings, Seung-Ryoung Jung, John Kelly, James B Hurley, Kenneth P Bube, Ian R Sweet
Publikováno v:
eLife, Vol 11 (2022)
Externí odkaz:
https://doaj.org/article/daffa97069b8453eab613e438909637c
Autor:
Varun Kamat, Brian M Robbings, Seung-Ryoung Jung, John Kelly, James B Hurley, Kenneth P Bube, Ian R Sweet
Publikováno v:
eLife, Vol 10 (2021)
Oxygen (O2) and other dissolved gases such as the gasotransmitters H2S, CO, and NO affect cell metabolism and function. To evaluate effects of dissolved gases on processes in tissue, we developed a fluidics system that controls dissolved gases while
Externí odkaz:
https://doaj.org/article/e186cd4d89774071854f6ad8c57ddb14
Autor:
Gavin Pharaoh, Varun Kamat, Sricharan Kannan, Rudolph S. Stuppard, Jeremy Whitson, Miguel Martin-Perez, Wei-Jun Qian, Michael J. MacCoss, Judit Villen, Peter Rabinovitch, Matthew D. Campbell, Ian R. Sweet, David J. Marcinek
Publikováno v:
bioRxiv
SUMMARYAging muscle experiences functional decline in part mediated by impaired mitochondrial ADP sensitivity. Elamipretide (ELAM) rapidly improves physiological and mitochondrial function in aging and binds directly to the mitochondrial ADP transpor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c98286de598fc2da4f8bdf9d060b0a
https://europepmc.org/articles/PMC9915686/
https://europepmc.org/articles/PMC9915686/
Autor:
Kylie S. Chichura, Clinton T. Elfers, Therese Salameh, Varun Kamat, Oleg G. Chepurny, Aelish McGivney, Brandon T. Milliken, George G. Holz, Sarah V. Applebey, Matthew R. Hayes, Ian R. Sweet, Christian L. Roth, Robert P. Doyle
SUMMARYMechanisms underlying long-term sustained weight loss and glycemic normalization after obesity surgery include changes in gut hormone levels, including glucagon-like peptide 1 (GLP-1) and peptide YY (PYY). We demonstrate that two peptide biase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4a1edc9bb65350578efbaeb4a774647
https://doi.org/10.1101/2022.11.07.515458
https://doi.org/10.1101/2022.11.07.515458
Autor:
George G. Holz, Sarah A. Doebley, Ian R. Sweet, Varun Kamat, Tito Borner, Robert P. Doyle, MacKenzie L. Swanson, Matthew R. Hayes, Bart C. De Jonghe, Ian C. Tinsley, Oleg G. Chepurny
Publikováno v:
Journal of Medicinal Chemistry
Corrination is the conjugation of a corrin ring containing molecule, such as vitamin B12 (B12) or B12 biosynthetic precursor dicyanocobinamide (Cbi), to small molecules, peptides, or proteins with the goal of modifying pharmacology. Recently, a corri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b061aa87a91447a8aee1a09b2bc098ec
http://europepmc.org/articles/PMC8279408
http://europepmc.org/articles/PMC8279408
Publikováno v:
International journal of experimental pathology. 103(4)
Islet autoantibodies, including autoantibodies directed against the 65kDa isoform of glutamate decarboxylase (GAD65Ab), are present in the majority of patients with newly diagnosed type 1 diabetes (T1D). Whereas these autoantibodies are historically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f495080417eb2e6023da6cefb71445a
https://pubmed.ncbi.nlm.nih.gov/35246889
https://pubmed.ncbi.nlm.nih.gov/35246889
Autor:
Seung-Ryoung Jung, Kenneth P. Bube, Ian R. Sweet, James B. Hurley, Varun Kamat, Brian M. Robbings, John Kelly
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Oxygen (O2) and other dissolved gases such as the gasotransmitters H2S, CO and NO affect cell metabolism and function. To evaluate effects of dissolved gases on processes in tissue, we developed a fluidics system that controls dissolved gases while s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faae04d1d480e9b87eae7843198d05a8
https://doi.org/10.7554/elife.66716
https://doi.org/10.7554/elife.66716