Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Varun, Prabhu"'
Autor:
Yali Fan, Jiandong Wang, Ziwei Fang, Stuart R. Pierce, Lindsay West, Allison Staley, Katherine Tucker, Yajie Yin, Wenchuan Sun, Weimin Kong, Varun Prabhu, Joshua E. Allen, Chunxiao Zhou, Victoria L. Bae-Jump
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
ONC201 is a promising first-in-class small molecule that has been reported to have anti-neoplastic activity in various types of cancer through activation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) as well as activation of mito
Externí odkaz:
https://doaj.org/article/f870a873615e49cebee45b48e7cb0d1e
Autor:
Yingao Zhang, Yu Huang, Yajie Yin, Yali Fan, Wenchuan Sun, Xiaoling Zhao, Katherine Tucker, Allison Staley, Sarah Paraghamian, Gabrielle Hawkins, Varun Prabhu, Joshua E. Allen, Chunxiao Zhou, Victoria Bae-Jump
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
ONC206 (Oncoceutics) is an imipiridone with nanomolar potency and analogue of ONC201, a selective dopamine receptor D2 (DRD2) antagonist currently being investigated in phase II clinical trials for serous endometrial cancer (SEC). This study investig
Externí odkaz:
https://doaj.org/article/bb4d20e1f81949ae997b56525b7b27a5
Autor:
Alexander G. Raufi, Arielle De La Cruz, Lindsey Carlsen, Kelsey Huntington, Lanlan Zhou, Varun Prabhu, Joshua Allen, Wafik S. El-Deiry
Publikováno v:
Cancer Research. 82:319-319
Pancreatic ductal adenocarcinoma (PDAC) is characterized by limited therapeutic options and an extremely high mortality-to-incidence ratio. Chemotherapy remains the primary treatment for metastatic disease and results in only modest improvements in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cbffaae25d2a989da8bca9cf84ba59a
https://doi.org/10.1158/1538-7445.am2022-319
https://doi.org/10.1158/1538-7445.am2022-319
Autor:
Alexander G. Raufi, Arielle De La Cruz, Andrew George, Sean Hacking, Venkateshwar Madka, Varun Prabhu, Howard Safran, Lanlan Zhou, Dean Brenner, Chinthalapally V. Rao, Wafik S. El-Deiry
Publikováno v:
Cancer Research. 82:2783-2783
Colorectal cancer (CRC) is the second leading cause of cancer-related death in the United States and currently the most effective method at reducing risk of death is through screening. Although these strategies have reduced the incidence of CRC, they
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f785445b8316aa97b11574bd665782c0
https://doi.org/10.1158/1538-7445.am2022-2783
https://doi.org/10.1158/1538-7445.am2022-2783
Autor:
Nicholas R. Liguori, Ashley Fss Uruchurtu, Young Lee, Leiqing Zhang, Abbas Abbas, Varun Prabhu, Lanlan Zhou, Christopher J. Azzoli, Wafik S. El-Deiry
Publikováno v:
Cancer Research. 82:4064-4064
Small cell lung cancer (SCLC) accounts for 15% of lung cancer and is responsive to chemotherapy but most patients relapse with drug-resistant disease and have very poor 5-year survival of less than 7%. One of the most notable advances in the last dec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f0e63a8588526bd940bef0c9f6a7cd6
https://doi.org/10.1158/1538-7445.am2022-4064
https://doi.org/10.1158/1538-7445.am2022-4064
Autor:
Peter M. Anderson, Matteo M. Trucco, Rohinton S. Tarapore, Stacey Zahler, Stefanie Thomas, Janette Gortz, Omar Mian, Martin Stoignew, Varun Prabhu, Sara Morrow, Joshua E. Allen
Publikováno v:
Clin Cancer Res
Purpose: Tumor dopamine-like DRD2 receptor expression is higher in pheochromocytoma-paraganglioma (PC-PG) compared with other cancers. ONC201 is a bitopic DRD2 antagonist with preclinical ONC201 activity in desmoplastic small round cell tumor (DSRCT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8cd3d1fe2ee38f7ad4707ac0bd914bd
https://pubmed.ncbi.nlm.nih.gov/35491654
https://pubmed.ncbi.nlm.nih.gov/35491654
Autor:
Jennifer C. Goodell, Sara M. Zimmerman, Cody J. Peer, Varun Prabhu, Tyler Yin, William J. Richardson, Arya Azinfar, John A. Dunn, Mark Mullin, Brett J. Theeler, Mark Gilbert, William D. Figg
Publikováno v:
J Pharm Biomed Anal
ONC206 is an imipridone derivative that is being developed clinically as a single agent given orally in a first-in-human trial (NCT04541082). This ongoing clinical trial requires pharmacokinetic analysis of ONC206 to fully characterize its pharmacolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93fa4f4582aaacc7e2e325f03f88ef0e
https://pubmed.ncbi.nlm.nih.gov/35219065
https://pubmed.ncbi.nlm.nih.gov/35219065
Autor:
Matthew J. Mosquera, Sungwoong Kim, Rohan Bareja, Zhou Fang, Shuangyi Cai, Heng Pan, Muhammad Asad, Maria Laura Martin, Michael Sigouros, Florencia M. Rowdo, Sarah Ackermann, Jared Capuano, Jacob Bernheim, Cynthia Cheung, Ashley Doane, Nicholas Brady, Richa Singh, David S. Rickman, Varun Prabhu, Joshua E. Allen, Loredana Puca, Ahmet F. Coskun, Mark A. Rubin, Himisha Beltran, Juan Miguel Mosquera, Olivier Elemento, Ankur Singh
Publikováno v:
Advanced Materials. 34:2270014
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab356c8f93d32c75c292e7e40c9688a1
https://doi.org/10.1002/adma.202270014
https://doi.org/10.1002/adma.202270014
Autor:
Allison Staley, Katherine Tucker, Ziwei Fang, Yali Fan, Wenchuan Sun, Yajie Yin, Yingao zhang, Varun Prabhu, Chunxiao Zhou, Victoria Bae-Jump
Publikováno v:
Cancer Research. 79:364-364
Objectives: ONC201 is an orally bioavailable dopamine receptor D2 antagonist that induces tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), and TRAIL has been implicated in both the physiopathology of ovarian cancer (OC) and obesity. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::291e82a4630bb795883740755460685d
https://doi.org/10.1158/1538-7445.am2019-364
https://doi.org/10.1158/1538-7445.am2019-364
Autor:
Jamal, Joudeh, Joshua E, Allen, Avisnata, Das, Varun, Prabhu, Michael, Farbaniec, Jeffrey, Adler, Wafik S, El-Deiry
Publikováno v:
Advances in experimental medicine and biology. 779
Cytotoxic chemotherapy remains the mainstay of the medical -management of colorectal cancer (CRC). Research over the last two decades has led to a molecular understanding of the oncogenic mechanisms involved in CRC and has contributed to the rational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::abe91c82943beab746f166db640d5064
https://pubmed.ncbi.nlm.nih.gov/23288633
https://pubmed.ncbi.nlm.nih.gov/23288633