Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Varsha Kaushal"'
Autor:
Gur P. Kaushal, Varsha Kaushal, Sudhir V. Shah, Randy S. Haun, Philip R. Mayeux, Christian Herzog
Publikováno v:
Biochemical and Biophysical Research Communications. 379:904-908
The present study demonstrates that both oligomeric metalloendopeptidase meprin A purified from kidney cortex and recombinant meprin alpha are capable of generating biologically active IL-1beta from its precursor pro-IL-1beta. Amino-acid sequencing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::636e741e95fb346863bdc5864f95afa8
https://doi.org/10.1016/j.bbrc.2008.12.161
https://doi.org/10.1016/j.bbrc.2008.12.161
Publikováno v:
American Journal of Physiology-Renal Physiology. 294:F777-F787
Autophagy has emerged as another major “programmed” mechanism to control life and death much like “programmed cell death” is for apoptosis in eukaryotes. We examined the expression of autophagic proteins and formation of autophagosomes during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3d1e232a644515c4c5b79eada1af80
https://doi.org/10.1152/ajprenal.00590.2007
https://doi.org/10.1152/ajprenal.00590.2007
Autor:
Eric R. Siegel, Manish Kohli, Perkins Mukunyadzi, Donald E. Johnson, Varsha Kaushal, Richard A. Dennis
Publikováno v:
Applied Immunohistochemistry & Molecular Morphology. 16:1-6
Tissue factor (TF), apart from its established role in hemostasis, has been implicated in promoting angiogenesis and metastasis in a wide array of tumors including prostate cancer. Expression of TF was evaluated in freshly-resected prostate specimens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e894d8c328aa7d583cf6fd38bae6c033
https://doi.org/10.1097/01.pai.0000213157.94804.fc
https://doi.org/10.1097/01.pai.0000213157.94804.fc
Publikováno v:
Cell Death & Differentiation. 15:530-544
This study examined the role of cisplatin-induced p53 activation in regulation of caspases and cellular injury during cisplatin nephrotoxicity. The executioner caspase-6 and -7 but not caspase-3 were identified as transcriptional targets of p53 in ci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6671aa85e9e8567881c46a7ccb27334f
https://doi.org/10.1038/sj.cdd.4402287
https://doi.org/10.1038/sj.cdd.4402287
Publikováno v:
American Journal of Physiology-Renal Physiology. 292:F1710-F1717
Mcl-1 is an antiapoptotic member of the Bcl-2 family that plays an important role in cell survival. We demonstrate that proteasome-dependent regulation of Mcl-1 plays a critical role in renal tubular epithelial cell injury from cisplatin. Protein lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9fda6e5f56d86b2b415ad35f6e083ae
https://doi.org/10.1152/ajprenal.00505.2006
https://doi.org/10.1152/ajprenal.00505.2006
Autor:
Eric R. Siegel, Perkins Mukunyadzi, Richard A. Dennis, Varsha Kaushal, Manish Kohli, Walter W. Chiles
Publikováno v:
The Prostate. 66:273-282
BACKGROUND Aberrant expression of protease-activated receptors (PARs) has been associated with increased angiogenesis, tumor growth, and metastasis of various cancers. We assessed the status of PAR1 expression in prostate cancer. METHODS The study co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afdceab30d36d5430c8c6d90335440b2
https://doi.org/10.1002/pros.20326
https://doi.org/10.1002/pros.20326
Publikováno v:
Journal of Biological Chemistry. 280:31230-31239
We demonstrate the role of p53-mediated caspase-2 activation in the mitochondrial release of apoptosis-inducing factor (AIF) in cisplatin-treated renal tubular epithelial cells. Gene silencing of AIF with its small interfering RNA (siRNA) suppressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c562a73c03a5c151551b820c9e3bf68
https://doi.org/10.1074/jbc.m503305200
https://doi.org/10.1074/jbc.m503305200
Autor:
Varsha Kaushal, Perkins Mukunyadzi, Richard A. Dennis, Eric R. Siegel, Donald E. Johnson, Manish Kohli
Publikováno v:
Clinical Cancer Research. 11:584-593
Purpose: The vascular endothelial growth factor (VEGF) family plays a critical role in tumor angiogenesis and lymphangiogenesis. We characterized, at the mRNA and protein levels, the expression of VEGF-A and VEGF-D and their cognate receptors, VEGFR-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d5e89ce85bce8b94375718570b39e6b
https://doi.org/10.1158/1078-0432.584.11.2
https://doi.org/10.1158/1078-0432.584.11.2
Publikováno v:
UroOncology. 4:113-118
Objectives: To determine cyclooxygenase-2 (COX-2) expression patterns in primary prostate tissue of patients undergoing androgen deprivation therapy and in patients with early stage disease. Methods: Gene and protein expression analysis were performe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc9f2eeb763dafe14e963c7af9ededa7
https://doi.org/10.1080/15610950410001732302
https://doi.org/10.1080/15610950410001732302
Publikováno v:
Endothelium. 11:253-258
Anthracyclines are known for their endothelial toxicity. Newer derivatives may have fewer toxic effects on endothelium. The authors therefore evaluated the effects of doxorubicin, doxorubicin analogs (daunorubicin, idarubicin), and pegylated liposoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39730a9d3e7a4de76d63e22b97073649
https://doi.org/10.1080/10623320490904124
https://doi.org/10.1080/10623320490904124