Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Varsha G. Desai"'
Publikováno v:
Bioinformatics and Biology Insights, Vol 2, Pp 323-334 (2008)
Background: Bioassays are routinely used to evaluate the toxicity of test agents. Experimental designs for bioassays are largely encompassed by fixed effects linear models. In toxicogenomics studies where DNA arrays measure mRNA levels, the tissue sa
Externí odkaz:
https://doaj.org/article/e927c4dd156d44c885fd77da26df1b84
Autor:
Varsha G. Desai, Taewon Lee, Carrie L. Moland, William S. Branham, Roberta A. Mittelstaedt, Sherry M. Lewis, Julian E. A. Leakey, James C. Fuscoe
Publikováno v:
AIDS Research and Treatment, Vol 2012 (2012)
The effects of 12-week exposure to zidovudine (AZT) at 400, 500, and 600 mg/kg/d were examined on expression of 542 mitochondria-related genes and mitochondrial DNA (mtDNA) copy number in the liver of male and female B6C3F1 mice to understand mitocho
Externí odkaz:
https://doaj.org/article/de3287a29a3c45bfb09c952ecd52aa43
Autor:
Li-Rong Yu, Varsha G. Desai
Publikováno v:
Biomarkers in Toxicology ISBN: 9783031073915
Biomarkers in Toxicology ISBN: 9783030872250
Biomarkers in Toxicology ISBN: 9783030872250
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff3d51fef08c9fc10179b24be2affaf
https://doi.org/10.1007/978-3-031-07392-2_44
https://doi.org/10.1007/978-3-031-07392-2_44
Autor:
Varsha G. Desai, Ana Azevedo‐Pouly, Vikrant Vijay, Bounleut Phanavanh, Carrie L. Moland, Tao Han, Javier Revollo, Baikuntha Aryal, V. Ashutosh Rao, James C. Fuscoe
Publikováno v:
Journal of applied toxicology : JATREFERENCES.
Preclinical and clinical findings suggest sexual dimorphism in cardiotoxicity induced by a chemotherapeutic drug, doxorubicin (DOX). However, molecular alterations leading to sex-related differential vulnerability of heart to DOX toxicity are not ful
Autor:
Varsha G. Desai, Vikrant Vijay, Taewon Lee, Tao Han, Carrie L. Moland, Bounleut Phanavanh, Eugene H. Herman, Kimo Stine, James C. Fuscoe
Publikováno v:
Journal of applied toxicology : JATREFERENCES. 42(9)
Cardiotoxicity is a serious adverse effect of an anticancer drug, doxorubicin (DOX), which can occur within a year or decades after completion of therapy. The present study was designed to address a knowledge gap concerning a lack of circulating biom
Autor:
Varsha G. Desai, Taewon Lee, Carrie L. Moland, Kelly Davis, Vikrant Vijay, Kimo C. Stine, James C. Fuscoe, Tao Han, Bounleut Phanavanh, Levan Muskhelishvili
Publikováno v:
Journal of applied toxicology : JATREFERENCES. 42(5)
Subclinical cardiotoxicity at low total cumulative doxorubicin (DOX) doses can manifest into cardiomyopathy in long-term cancer survivors. However, the underlying mechanisms are poorly understood. In male B6C3F1 mice, assessment of cardiac function b
Autor:
Yu-Chuan Chen, Noriko Nakamura, Deborah K. Hansen, Tao Han, Barry S. McIntyre, Varsha G. Desai, Wafa Harrouk, Ching-Wei Chang, James C. Fuscoe, Paul M. D. Foster, Amy L. Inselman, Vikrant Vijay
Publikováno v:
Reproductive Toxicology. 82:111-123
2-hydroxy-4-methoxybenzophenone (HMB) is an ultraviolet light-absorbing compound that is used in sunscreens, cosmetics and plastics. HMB has been reported to have weak estrogenic activity by in vivo and in vitro studies, making it a chemical with pot
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e75305 (2013)
Age is a predisposing condition for susceptibility to chronic kidney disease and progression as well as acute kidney injury that may arise due to the adverse effects of some drugs. Age-related differences in kidney biology, therefore, are a key conce
Externí odkaz:
https://doaj.org/article/0b9472c323f54218b1a985a04e0c7179
Autor:
Shikha Prasad, Mohammad A. Kaisar, Vikrant Vijay, Ravi K. Sajja, Luca Cucullo, Varsha G. Desai
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
Scientific Reports
Sulforaphane (SFN) has been shown to protect the brain vascular system and effectively reduce ischemic injuries and cognitive deficits. Given the robust cerebrovascular protection afforded by SFN, the objective of this study was to profile these effe
Autor:
Taewon Lee, Levan Muskhelishvili, James C. Fuscoe, Eugene H. Herman, Carrie L. Moland, Susan Kerr, Kelly Davis, G. Ronald Jenkins, Vikrant Vijay, Varsha G. Desai, Sherry M. Lewis
Publikováno v:
Toxicology and Applied Pharmacology. 310:159-174
Sex is a risk factor for development of cardiotoxicity, induced by the anti-cancer drug, doxorubicin (DOX), in humans. To explore potential mechanisms underlying differential susceptibility to DOX between sexes, 8-week old male and female B6C3F1 mice