The ying and yang of idebenone: Not too little, not too much – cell death in NQO1 deficient cells and the mouse retina

Autor: Varricchio, C., Beirne, K., Heard, C., Newland, B., Rozanowska, M., Brancale, A., Votruba, M.

Publikováno v: In Free Radical Biology and Medicine 20 May 2020 152:551-560

Correction: Notch3-regulated microRNAs impair CXCR4-dependent maturation of thymocytes allowing maintenance and progression of T-ALL.

Autor: Sergio I; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy., Varricchio C; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Patel SK; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Del Gaizo M; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy., Russo E; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Orlando A; Division of Hematology & Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Peruzzi G; Center for Life Nano-Neuro Science, IIT, Rome, Italy., Ferrandino F; A.O.R.N. dei colli Monaldi V., Napoli, Italy., Tsaouli G; Department of Medical-Surgical Science and Translational Medicine, Sapienza University of Rome, Rome, Italy., Coni S; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Peluso D; Ph.D School of Applied Medical-Surgical Sciences, Department of Biology, University of Rome 'Tor Vergata', Rome, Italy., Besharat ZM; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy., Campolo F; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy., Venneri MA; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy., Del Bufalo D; Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy., Lai S; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy., Indraccolo S; Department of Surgery Oncology and Gastroenterology, University of Padua, Padua, Italy.; Basic and Translational Oncology Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy., Minuzzo S; Department of Surgery Oncology and Gastroenterology, University of Padua, Padua, Italy., La Starza R; Hematology Section, Department of Medicine and Surgery, and S. Maria Della Misericordia Hospital Perugia, CREO, Perugia, Italy., Bernardini G; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Screpanti I; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Campese AF; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Felli MP; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy. mariapia.felli@uniroma1.it.

Publikováno v: Oncogene [Oncogene] 2024 Aug; Vol. 43 (34), pp. 2611.

NMNAT2 is a druggable target to drive neuronal NAD production.

Autor: Tribble JR; Department of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital; Karolinska Institutet, Stockholm, Sweden., Jöe M; Department of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital; Karolinska Institutet, Stockholm, Sweden., Varricchio C; School of Pharmacy and Pharmaceutical Sciences; Cardiff University, Cardiff, Wales, UK., Otmani A; Department of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital; Karolinska Institutet, Stockholm, Sweden., Canovai A; Department of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital; Karolinska Institutet, Stockholm, Sweden.; Department of Biology, University of Pisa, 56127, Pisa, Italy., Habchi B; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.; Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden.; C2VN, INRAE, INSERM, Aix Marseille University, 13007, Marseille, France., Daskalakis E; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.; Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden., Chaleckis R; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.; Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden.; Gunma Initiative for Advanced Research (GIAR), Gunma University, Maebashi, Japan., Loreto A; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences; University of Cambridge, Cambridge, UK.; School of Medical Sciences and Save Sight Institute, Charles Perkins Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia., Gilley J; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences; University of Cambridge, Cambridge, UK., Wheelock CE; Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.; Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden., Jóhannesson G; Department of Clinical Sciences, Ophthalmology, Umeå University, 901 85, Umeå, Sweden.; Wallenberg Centre of Molecular Medicine, Umeå University, 901 85, Umeå, Sweden., Wong RCB; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.; Ophthalmology, Department of Surgery, University of Melbourne, East Melbourne, Victoria, Australia., Coleman MP; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences; University of Cambridge, Cambridge, UK., Brancale A; School of Pharmacy and Pharmaceutical Sciences; Cardiff University, Cardiff, Wales, UK.; Vysoká škola chemicko-technologická v Praze, Prague, Czech Republic., Williams PA; Department of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital; Karolinska Institutet, Stockholm, Sweden. pete.williams@ki.se.

Publikováno v: Nature communications [Nat Commun] 2024 Jul 24; Vol. 15 (1), pp. 6256. Date of Electronic Publication: 2024 Jul 24.

Thymic-Epithelial-Cell-Dependent Microenvironment Influences Proliferation and Apoptosis of Leukemic Cells.

Autor: Patel SK; Department of Molecular Medicine, Sapienza University of Rome, 00161 Roma, Italy., Zhdanovskaya N; Department of Molecular Medicine, Sapienza University of Rome, 00161 Roma, Italy., Sergio I; Department of Experimental Medicine, Sapienza University of Rome, 00161 Roma, Italy., Cardinale A; Research Area of Hematology and Oncology, Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00146 Rome, Italy., Rosichini M; Research Area of Hematology and Oncology, Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00146 Rome, Italy., Varricchio C; Department of Molecular Medicine, Sapienza University of Rome, 00161 Roma, Italy., Pace E; Department of Molecular Medicine, Sapienza University of Rome, 00161 Roma, Italy., Capalbo C; Department of Molecular Medicine, Sapienza University of Rome, 00161 Roma, Italy., Locatelli F; Research Area of Hematology and Oncology, Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00146 Rome, Italy.; Department of Life Sciences and Public Health, Catholic University of the Sacred Heart, 12631 Rome, Italy., Macone A; Department of Biochemical Sciences 'A. Rossi Fanelli', Sapienza University of Rome, 00161 Roma, Italy., Velardi E; Research Area of Hematology and Oncology, Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00146 Rome, Italy., Palermo R; Department of Molecular Medicine, Sapienza University of Rome, 00161 Roma, Italy., Felli MP; Department of Experimental Medicine, Sapienza University of Rome, 00161 Roma, Italy.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Jan 24; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 24.

Structure-Activity Relationships, Tolerability and Efficacy of Microtubule-Active 1,2,4-Triazolo[1,5-a]pyrimidines as Potential Candidates to Treat Human African Trypanosomiasis.

Autor: Monti L; Center for Discovery and Innovation in Parasitic Diseases (CDIPD), Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, 92093, La Jolla, CA, USA.; Present affiliation: Chemistry Department, Molecular Sciences Research Hub, Imperial College London, 82 Wood Lane, W12 0BZ, London, UK., Liu LJ; Center for Discovery and Innovation in Parasitic Diseases (CDIPD), Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, 92093, La Jolla, CA, USA., Varricchio C; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, CF103NB, Cardiff, UK., Lucero B; Center for Discovery and Innovation in Parasitic Diseases (CDIPD), Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, 92093, La Jolla, CA, USA.; Department of Chemistry & Biochemistry, University of California, San Diego, 9500 Gilman Drive, 92093, La Jolla, CA, USA., Alle T; Center for Discovery and Innovation in Parasitic Diseases (CDIPD), Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, 92093, La Jolla, CA, USA., Yang W; Center for Discovery and Innovation in Parasitic Diseases (CDIPD), Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, 92093, La Jolla, CA, USA., Bem-Shalom I; Center for Discovery and Innovation in Parasitic Diseases (CDIPD), Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, 92093, La Jolla, CA, USA., Gilson M; Center for Discovery and Innovation in Parasitic Diseases (CDIPD), Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, 92093, La Jolla, CA, USA., Brunden KR; Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, 3600 Spruce Street, 19104-6323, Philadelphia, PA, USA., Brancale A; Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, CF103NB, Cardiff, UK.; Present affiliation: Vysoká škola chemicko-technologická v Praze, Department of Organic Chemistry, Technická 5, 16628, Prague 6, Czech Republic., Caffrey CR; Center for Discovery and Innovation in Parasitic Diseases (CDIPD), Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, 92093, La Jolla, CA, USA., Ballatore C; Center for Discovery and Innovation in Parasitic Diseases (CDIPD), Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, 92093, La Jolla, CA, USA.

Publikováno v: ChemMedChem [ChemMedChem] 2023 Oct 17; Vol. 18 (20), pp. e202300193. Date of Electronic Publication: 2023 Jul 24.