Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Varnika, Roy"'
Autor:
Li Ma, Matthew Brecher, Allison Soufal, Tiziano Gaiotto, Sai Tian, Sumana Chandramouli, Vincent Dewar, Laurent Ferrant, Meng Zhang, Xianzhi Zhou, Varnika Roy
Publikováno v:
Vaccine. 41:3308-3316
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0960fca34c47a2343a6984c032ea97a3
https://doi.org/10.1016/j.vaccine.2023.04.021
https://doi.org/10.1016/j.vaccine.2023.04.021
Autor:
Andrew C Nyborg, Chris Ward, Anna Zacco, Benoy Chacko, Luba Grinberg, James C Geoghegan, Ryan Bean, Michaela Wendeler, Frank Bartnik, Ellen O'Connor, Flaviu Gruia, Vidyashankara Iyer, Hui Feng, Varnika Roy, Mark Berge, Jeffrey N Miner, David M Wilson, Dongmei Zhou, Simone Nicholson, Clynn Wilker, Chi Y Wu, Susan Wilson, Lutz Jermutus, Herren Wu, David A Owen, Jane Osbourn, Steven Coats, Manuel Baca
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167935 (2016)
Humans and higher primates are unique in that they lack uricase, the enzyme capable of oxidizing uric acid. As a consequence of this enzyme deficiency, humans have high serum uric acid levels. In some people, uric acid levels rise above the solubilit
Externí odkaz:
https://doaj.org/article/c7112dc536a744a789e3b298aa48181d
Autor:
Varnika Roy, Mark Berge, Srilatha Kuntumalla, Robert G. Roth, Albert E. Schmelzer, Rajesh Chitta, Ron Schoner, Sucheta Vajrala
Publikováno v:
Biotechnology and Bioengineering. 114:1753-1761
Human neurturin (NTN) is a cystine knot growth factor with potential therapeutic use in diseases such as Parkinson's and diabetes. Scalable high titer production of native NTN is particularly challenging because of the cystine knot structure which co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a97dae58c3158fbc6d4bfb9a36b5f1aa
https://doi.org/10.1002/bit.26299
https://doi.org/10.1002/bit.26299
Autor:
Natalia I. Majewska, Rod Brian C. Jimenez, Rey W. Martin, Thomas Albanetti, Varnika Roy, Albert E. Schmelzer, Cindy X. Chen, Michael C. Jewett
Publikováno v:
ACS synthetic biology. 6(7)
Chinese Hamster Ovary (CHO) cells are routinely optimized to stably express monoclonal antibodies (mAbs) at high titers. At the early stages of lead isolation and optimization, hundreds of sequences for the target protein of interest are screened. Ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d77be13f9c1bf0f19150ed84f54162b5
https://pubmed.ncbi.nlm.nih.gov/28350472
https://pubmed.ncbi.nlm.nih.gov/28350472
Autor:
Varnika, Roy, Robert, Roth, Mark, Berge, Rajesh, Chitta, Sucheta, Vajrala, Srilatha, Kuntumalla, Albert, E Schmelzer, Ron, Schoner
Publikováno v:
Biotechnology and bioengineering. 114(8)
Human neurturin (NTN) is a cystine knot growth factor with potential therapeutic use in diseases such as Parkinson's and diabetes. Scalable high titer production of native NTN is particularly challenging because of the cystine knot structure which co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a8d1fb27d9bc06f31a23b60ba581f57f
https://pubmed.ncbi.nlm.nih.gov/28369693
https://pubmed.ncbi.nlm.nih.gov/28369693
Autor:
William E. Bentley, Min Guo, Sonja Gamby, Jingxin Wang, Herman O. Sintim, Jessica E. Stewart, Jacqueline A. I. Smith, Xiao Wang, Varnika Roy
Publikováno v:
ACS Chemical Biology. 7:1023-1030
There have been intensive efforts to find small molecule antagonists for bacterial quorum sensing (QS) mediated by the "universal" QS autoinducer, AI-2. Previous work has shown that linear and branched acyl analogues of AI-2 can selectively modulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08884135576300e9f6c3aaa1ee9a21a
https://doi.org/10.1021/cb200524y
https://doi.org/10.1021/cb200524y
Autor:
Kishore Kamaraju, Sergei Sukharev, Jingxin Wang, Jacqueline A. I. Smith, Herman O. Sintim, William E. Bentley, Varnika Roy
Publikováno v:
Biochemistry. 50:6983-6993
Quorum sensing is an intricate example of "social" behavior in microbial communities mediated by small secreted molecules (autoinducers). The mechanisms of membrane permeation remain elusive for many of them. Here we present the assessment of membran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::613187ded6723ddb1b8da3045cdd8b66
https://doi.org/10.1021/bi200684z
https://doi.org/10.1021/bi200684z
Autor:
William E. Bentley, Jingxin Wang, Jessica E. Stewart, Varnika Roy, Jacqueline A. I. Smith, Herman O. Sintim
Publikováno v:
Journal of the American Chemical Society. 132:11141-11150
The widespread use of antibiotics and the emergence of resistant strains call for new approaches to treat bacterial infection. Bacterial cell-cell communication or "quorum sensing" (QS) is mediated by "signatures" of small molecules that represent ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::180ed7d705d28558650a9a362dc6e9c5
https://doi.org/10.1021/ja102587w
https://doi.org/10.1021/ja102587w
Autor:
Flaviu Gruia, Jeffrey N. Miner, Frank Bartnik, David M. Wilson, Luba Grinberg, Ryan Bean, Jane K. Osbourn, Herren Wu, Hui Feng, Lutz Jermutus, James C. Geoghegan, Benoy Chacko, Vidyashankara Iyer, Susan Wilson, David A. Owen, Manuel Baca, Simone M Nicholson, Varnika Roy, Mark Berge, Anna Zacco, Steven Coats, Dongmei Zhou, Ellen O'Connor, Chris Ward, Chi Y. Wu, Michaela Wendeler, Andrew C. Nyborg, Clynn Wilker
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167935 (2016)
PLoS ONE
PLoS ONE
Humans and higher primates are unique in that they lack uricase, the enzyme capable of oxidizing uric acid. As a consequence of this enzyme deficiency, humans have high serum uric acid levels. In some people, uric acid levels rise above the solubilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df45eac80f2884a9b59b9882e9909d96
https://doi.org/10.1371/journal.pone.0167935
https://doi.org/10.1371/journal.pone.0167935
Autor:
Varnika Roy, Mariana T. Meyer, Herman O. Sintim, Jacqueline A. I. Smith, Reza Ghodssi, William E. Bentley, Sonja Gamby
Publikováno v:
Applied microbiology and biotechnology. 97(6)
Quorum sensing (QS), the process of autoinducer-mediated cell–cell signaling among bacteria, facilitates biofilm formation, virulence, and many other multicellular phenotypes. QS inhibitors are being investigated as antimicrobials because of their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a79a9d7c18beeb3504ceead51fbffbdb
https://pubmed.ncbi.nlm.nih.gov/23053069
https://pubmed.ncbi.nlm.nih.gov/23053069