Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting.

Autor: Huard K; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Smith AC; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Cappon G; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Dow RL; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Edmonds DJ; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., El-Kattan A; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Esler WP; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Fernando DP; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Griffith DA; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Kalgutkar AS; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Ross TT; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Bagley SW; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Beebe D; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Bi YA; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Cabral S; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Crowley C; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Doran SD; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Dowling MS; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Liras S; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Mascitti V; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Niosi M; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Pfefferkorn JA; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Polivkova J; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Préville C; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Price DA; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Shavnya A; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Shirai N; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Smith AH; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Southers JR; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Tess DA; Pfizer Worldwide Research and Development, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Thuma BA; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Varma MV; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States., Yang X; Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 Oct 08; Vol. 63 (19), pp. 10879-10896. Date of Electronic Publication: 2020 Sep 18.

增材制造技术的临床应用.

Autor: 程玮璐¹, 刘英慧¹

Publikováno v: Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu. 6/18/2024, Vol. 28 Issue 17, p2782-2788. 7p.

Toxicity and biodistribution of alginate-stabilized AgNPs upon 14-days repeated dose oral administration in mice.

Autor: Perkasa, Dian Pribadi¹, Arozal, Wawaimuli² wawaimuli.arozal@ui.ac.id, Kusmardi, Kusmardi³, Syaifudin, Mukh⁴, Purwanti, Tri⁵, Laksmana, Roza Indra⁵, Pratama, Afiq Azfar⁵, Sugoro, Irawan¹, Rahayu, Dien Puji¹

Publikováno v: Journal of Applied Pharmaceutical Science. Jun2024, Vol. 14 Issue 6, p135-146. 12p.

Physiologically-Based Pharmacokinetic Modeling Approach to Predict Rifampin-Mediated Intestinal P-Glycoprotein Induction.

Autor: Yamazaki S; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research & Development, San Diego, California, USA., Costales C; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research & Development, Groton, Connecticut, USA., Lazzaro S; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research & Development, Groton, Connecticut, USA., Eatemadpour S; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research & Development, Groton, Connecticut, USA., Kimoto E; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research & Development, Groton, Connecticut, USA., Varma MV; Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research & Development, Groton, Connecticut, USA.

Publikováno v: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2019 Sep; Vol. 8 (9), pp. 634-642. Date of Electronic Publication: 2019 Sep 05.

Transporter-Mediated Hepatic Uptake Plays an Important Role in the Pharmacokinetics and Drug-Drug Interactions of Montelukast.

Autor: Varma, MV, Kimoto, E, Scialis, R, Bi, Y, Lin, J, Eng, H, Kalgutkar, AS, El‐Kattan, AF, Rodrigues, AD, Tremaine, LM

Publikováno v: Clinical Pharmacology & Therapeutics; Mar2017, Vol. 101 Issue 3, p406-415, 10p