Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Varintra E. Lander"'
Autor:
C. Alston. James, John M. Baer, Chong Zuo, Usman Y. Panni, Brett L. Knolhoff, Graham D. Hogg, Natalie L. Kingston, Liang-I Kang, Varintra E. Lander, Jingqin Luo, Yu Tao, Mark A. Watson, Rebecca Aft, Ryan C. Fields, William G. Hawkins, David G. DeNardo
Publikováno v:
Cancer Immunology Research.
Intratumoral T-cell dysfunction is a hallmark of pancreatic tumors, and efforts to improve dendritic cell (DC)-mediated T-cell activation may be critical in treating these immune therapy unresponsive tumors. Recent evidence indicates that mechanisms
Autor:
Xiuting Liu, Graham D. Hogg, Chong Zuo, Nicholas C. Borcherding, John M. Baer, Varintra E. Lander, Liang-I Kang, Brett L. Knolhoff, Faiz Ahmad, Robin E. Osterhout, Anna V. Galkin, Jean-Marie Bruey, Laura L. Carter, Cedric Mpoy, Kiran R. Vij, Ryan C. Fields, Julie K. Schwarz, Haeseong Park, Vineet Gupta, David G. DeNardo
Publikováno v:
Cancer Cell.
Autor:
David G. DeNardo, Hyun Kim, Julie K. Schwarz, Buck E. Rogers, Michael Zahner, Jalen Scott, Cedric Mpoy, Daniel P. Lander, Nicholas C. Borcherding, Chong Zuo, John M. Baer, Savannah J. Bogner, Brett L. Knolhoff, Liang-I Kang, Xiuting Liu, Graham D. Hogg, John M. Herndon, Natalie L. Kingston, Jad I. Belle, Varintra E. Lander
The effects of radiotherapy (RT) on tumor immunity in pancreatic ductal adenocarcinoma (PDAC) are not well understood. To better understand if RT can prime antigen-specific T-cell responses, we analyzed human PDAC tissues and mouse models. In both se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f7001041d74584b705d27bbfb384c1
https://doi.org/10.1158/2159-8290.c.6549747
https://doi.org/10.1158/2159-8290.c.6549747
Autor:
David G. DeNardo, Hyun Kim, Julie K. Schwarz, Buck E. Rogers, Michael Zahner, Jalen Scott, Cedric Mpoy, Daniel P. Lander, Nicholas C. Borcherding, Chong Zuo, John M. Baer, Savannah J. Bogner, Brett L. Knolhoff, Liang-I Kang, Xiuting Liu, Graham D. Hogg, John M. Herndon, Natalie L. Kingston, Jad I. Belle, Varintra E. Lander
Supplementary Table from Stromal Reprogramming by FAK Inhibition Overcomes Radiation Resistance to Allow for Immune Priming and Response to Checkpoint Blockade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79ed75015c59cd30d2021db1b9d2ece
https://doi.org/10.1158/2159-8290.22541799
https://doi.org/10.1158/2159-8290.22541799
Autor:
David G. DeNardo, Hyun Kim, Julie K. Schwarz, Buck E. Rogers, Michael Zahner, Jalen Scott, Cedric Mpoy, Daniel P. Lander, Nicholas C. Borcherding, Chong Zuo, John M. Baer, Savannah J. Bogner, Brett L. Knolhoff, Liang-I Kang, Xiuting Liu, Graham D. Hogg, John M. Herndon, Natalie L. Kingston, Jad I. Belle, Varintra E. Lander
Supplementary Figure from Stromal Reprogramming by FAK Inhibition Overcomes Radiation Resistance to Allow for Immune Priming and Response to Checkpoint Blockade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f80b39bd397158d0a497c9bb3e7dd92
https://doi.org/10.1158/2159-8290.22541817.v1
https://doi.org/10.1158/2159-8290.22541817.v1
Autor:
Chong Zuo, John M. Baer, Brett L. Knolhoff, Jad I. Belle, Xiuting Liu, Angela Alarcon De La Lastra, Christina Fu, Graham D. Hogg, Natalie L. Kingston, Marcus A. Breden, Paarth B. Dodhiawala, Daniel Cui Zhou, Varintra E. Lander, C. Alston James, Li Ding, Kian-Huat Lim, Ryan C. Fields, William G. Hawkins, Jason D. Weber, Guoyan Zhao, David G. DeNardo
Publikováno v:
Journal of Experimental Medicine. 220
Tumor-associated macrophages (TAMs) are abundant in pancreatic ductal adenocarcinomas (PDACs). While TAMs are known to proliferate in cancer tissues, the impact of this on macrophage phenotype and disease progression is poorly understood. We showed t
Autor:
Varintra E. Lander, Jad I. Belle, Natalie L. Kingston, John M. Herndon, Graham D. Hogg, Xiuting Liu, Liang-I Kang, Brett L. Knolhoff, Savannah J. Bogner, John M. Baer, Chong Zuo, Nicholas C. Borcherding, Daniel P. Lander, Cedric Mpoy, Jalen Scott, Michael Zahner, Buck E. Rogers, Julie K. Schwarz, Hyun Kim, David G. DeNardo
Publikováno v:
Cancer Discov
The effects of radiotherapy (RT) on tumor immunity in pancreatic ductal adenocarcinoma (PDAC) are not well understood. To better understand if RT can prime antigen-specific T-cell responses, we analyzed human PDAC tissues and mouse models. In both se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b84525687b295f67bf75f77dac77d1
https://europepmc.org/articles/PMC9722639/
https://europepmc.org/articles/PMC9722639/
Autor:
Xiuting Liu, Graham D. Hogg, Chong Zuo, John M Baer, Varintra E. Lander, Liang Kang, Nicholas C. Borcherding, Brett L. Knolhoff, Robin E. Osterhout, Anna V. Galkin, Jean-Marie Bruey, Laura L. Carter, Cedric Mpoy, Julie K. Schwarz, Haeseong Park, Vineet Gupta, David G. DeNardo
Chronic activation of inflammatory pathways and suppressed interferon signaling are hallmarks of myeloid cells in immunosuppressive tumors that drive poor responsiveness to conventional and immune therapies. Previous studies have identified agonistic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d977918d9b74994bc7047294697c6beb
https://doi.org/10.1101/2022.03.22.485233
https://doi.org/10.1101/2022.03.22.485233
Autor:
Vikas K. Somani, Daoxiang Zhang, Paarth B. Dodhiawala, Varintra E. Lander, Xiuting Liu, Liang-I Kang, Hung-Po Chen, Brett L. Knolhoff, Lin Li, Patrick M. Grierson, Marianna B. Ruzinova, David G. DeNardo, Kian-Huat Lim
Publikováno v:
Gastroenterology
BACKGROUND AND AIMS: Checkpoint immunotherapy is largely ineffective in pancreatic ductal adenocarcinoma (PDAC). The innate immune NF-κB pathway promotes PDAC cell survival, stromal fibrosis and is driven by IRAK4, but its impact on tumor immunity h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4562bfab406605961318f6d6f9340217
https://europepmc.org/articles/PMC9387774/
https://europepmc.org/articles/PMC9387774/
Autor:
Jad I. Belle, Varintra E. Lander, David G. DeNardo, Cedric Mpoy, Buck E. Rogers, Julie K. Schwarz, Brett L. Knolhoff, John M. Herndon
Publikováno v:
Cancer Research. 81:PO-112
Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most lethal malignancies. While checkpoint immunotherapies are effective therapies in many solid malignancies, these same regimens have not been effective in PDAC. Furthermore, clinical trials com