Zobrazeno 1 - 10
of 965
pro vyhledávání: '"Variant genotypes"'
Autor:
Alexander Klug, Joachim Krug
Publikováno v:
PLoS Computational Biology, 18 (11)
Understanding the benefits and costs of recombination under different scenarios of evolutionary adaptation remains an open problem for theoretical and experimental research. In this study, we focus on finite populations evolving on neutral networks c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0e4fd6dd0de5bbee75d128766cf27b
https://pubmed.ncbi.nlm.nih.gov/36409763
https://pubmed.ncbi.nlm.nih.gov/36409763
Autor:
Maria Sabater Molina, Elisa Nicolás Rocamora, Asunción Iborra Bendicho, Elisa García Vázquez, Esther Zorio, Fernando Domínguez Rodriguez, Cristina Gil Ortuño, Ana Isabel Rodríguez, Antonio J. Sánchez-López, Rubén Jara Rubio, Antonio Moreno-Docón, Pedro J. Marcos, Pablo García Pavía, Roberto Barriales Villa, Juan R. Gimeno Blanes
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 2, p e0263140 (2022)
PLoS ONE, Vol 17, Iss 2, p e0263140 (2022)
Infection by the SARS-Cov-2 virus produces in humans a disease of highly variable and unpredictable severity. The presence of frequent genetic single nucleotide polymorphisms (SNPs) in the population might lead to a greater susceptibility to infectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c5c57dd3fbb428752448fd705a3700
http://europepmc.org/articles/PMC8815985
http://europepmc.org/articles/PMC8815985
Autor:
Ya-Ping Li, Chen-Rui Liu, Hui-Ling Deng, Mu-Qi Wang, Yan Tian, Yuan Chen, Yu-Feng Zhang, Shuang-Suo Dang, Song Zhai
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 1, p e0010090 (2022)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Background This research aimed to explore the association between the RIG-I-like receptor (RIG-I and MDA5 encoded by DDX58 and IFIH1, respectively) pathways and the risk or severity of hand, foot, and mouth disease caused by enterovirus 71 (EV71-HFMD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c212d2f3cec52df8a2fffdd0db021914
https://doaj.org/article/c7f37fc07d0147399952e111ba49029d
https://doaj.org/article/c7f37fc07d0147399952e111ba49029d
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0262574 (2022)
PLoS ONE, Vol 17, Iss 1 (2022)
PLoS ONE, Vol 17, Iss 1, p e0262574 (2022)
PLoS ONE, Vol 17, Iss 1 (2022)
Single nucleotide polymorphisms (SNPs) are widely used in genome-wide association studies and population genetics analyses. Next-generation sequencing (NGS) has become convenient, and many SNP-calling pipelines have been developed for human NGS data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32abade7c4a107b9e2768b7539bb6a5b
http://europepmc.org/articles/PMC8803190
http://europepmc.org/articles/PMC8803190
Autor:
Taruna Rajagopal, Arun Seshachalam, Krishna Kumar Rathnam, Srikanth Talluri, Sivaramakrishnan Venkatabalasubramanian, Nageswara Rao Dunna
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0259761 (2022)
PLoS ONE
PLoS ONE, Vol 17, Iss 1 (2022)
PLoS ONE
PLoS ONE, Vol 17, Iss 1 (2022)
BackgroundHomologous recombination repair (HRR) accurately repairs the DNA double-strand breaks (DSBs) and is crucial for genome stability. Genetic polymorphisms in crucial HRR pathway genes might affect genome stability and promote tumorigenesis. Up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9313a7cf96879c26069d52d1e6d007
https://doaj.org/article/7631d763b75d4044a86f1869fa56e281
https://doaj.org/article/7631d763b75d4044a86f1869fa56e281
Autor:
Akihiro Kuno, Yoshihisa Ikeda, Shinya Ayabe, Kanako Kato, Kotaro Sakamoto, Sayaka R. Suzuki, Kento Morimoto, Arata Wakimoto, Natsuki Mikami, Miyuki Ishida, Natsumi Iki, Yuko Hamada, Megumi Takemura, Yoko Daitoku, Yoko Tanimoto, Tra Thi Huong Dinh, Kazuya Murata, Michito Hamada, Masafumi Muratani, Atsushi Yoshiki, Fumihiro Sugiyama, Satoru Takahashi, Seiya Mizuno
Publikováno v:
PLoS Biology, Vol 20, Iss 1, p e3001507 (2022)
PLoS Biology
PLoS Biology
Genome editing can introduce designed mutations into a target genomic site. Recent research has revealed that it can also induce various unintended events such as structural variations, small indels, and substitutions at, and in some cases, away from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::187cd116e76b734f185ade1402cbdeaa
https://doaj.org/article/5f760da4e186465fbccfd7a92fa023f0
https://doaj.org/article/5f760da4e186465fbccfd7a92fa023f0
Autor:
Paul Williams
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0262395 (2022)
PLoS ONE, Vol 17, Iss 1, p e0262395 (2022)
BackgroundFibrinogen is a moderately heritable blood protein showing different genetic effects by sex, race, smoking status, pollution exposure, and disease status. These interactions may be explained in part by “quantile-dependent expressivity”,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acee1928e3c10f16682326f3ce53cfc3
http://europepmc.org/articles/PMC8741049
http://europepmc.org/articles/PMC8741049
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 12, p e0010001 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Introduction In Colombia, organochloride, organophosphate, carbamate, and pyrethroid insecticides are broadly used to control Aedes aegypti populations. However, Colombian mosquito populations have shown variability in their susceptibility profiles t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fbb7e718673ce6c4794cb0cd6db4a5e
https://doaj.org/article/f8ecb487d70f49b28e76e1a0f84bcb82
https://doaj.org/article/f8ecb487d70f49b28e76e1a0f84bcb82
Autor:
Andres Ruiz-Linares, Pierre Faux, Pascal Bailly, Caroline Costedoat, Jacques Chiaroni, Silvana Condemi, Stéphane Mazières
Publikováno v:
Human Evolution-From Fossils to Ancient and Modern Genomes 2021
Human Evolution-From Fossils to Ancient and Modern Genomes 2021, Nov 2021, virtual conference, United Kingdom
PLoS ONE
PLoS ONE, Public Library of Science, 2021, 16 (7), pp.e0254175. ⟨10.1371/journal.pone.0254175⟩
PLoS ONE, Vol 16, Iss 7, p e0254175 (2021)
PLoS ONE, 2021, 16 (7), pp.e0254175. ⟨10.1371/journal.pone.0254175⟩
Human Evolution-From Fossils to Ancient and Modern Genomes 2021, Nov 2021, virtual conference, United Kingdom
PLoS ONE
PLoS ONE, Public Library of Science, 2021, 16 (7), pp.e0254175. ⟨10.1371/journal.pone.0254175⟩
PLoS ONE, Vol 16, Iss 7, p e0254175 (2021)
PLoS ONE, 2021, 16 (7), pp.e0254175. ⟨10.1371/journal.pone.0254175⟩
International audience; Red cell blood group systems are crucial for safe transfusion, transplantation, and pregnancy monitoring. In addition, blood groups have long been investigated to decipher the origin of human populations, migration, adaptation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee54fc8f2635ca009b8d8f22d503a545
https://hal.archives-ouvertes.fr/hal-03517940/document
https://hal.archives-ouvertes.fr/hal-03517940/document
Autor:
Leena Omereltinai, Muzamil Mahdi Abdel Hamid, Abdelrahim O. Mohamad, Sara B. Eltom, Nouh S. Mohamed, Musab M. Ali Albsheer, Andrew A. Lover, Mohamed S. Muneer
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 10 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009720 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009720 (2021)
Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is the most common enzymopathy globally, and deficient individuals may experience severe hemolysis following treatment with 8-aminoquinolines. With increasing evidence of Plasmodium vivax infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fed6d1f79974b7d3dd7e6b6c8bb8beb
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547650/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547650/?tool=EBI