Zobrazeno 1 - 10
of 245
pro vyhledávání: '"Variant allele frequency"'
Publikováno v:
Alexandria Journal of Medicine, Vol 60, Iss 1, Pp 259-264 (2024)
Background Acute myeloid leukemia (AML) is a clonal hematopoietic stem cell malignancy characterized by the accumulation of myeloid progenitor cells with arrested differentiation, leading to the suppression of normal hematopoiesis. The disease exhibi
Externí odkaz:
https://doaj.org/article/722ae48307d1464a98a6dc83d9f7fe80
Autor:
Ekaterina Kalashnikova, Vasily N. Aushev, Allyson Koyen Malashevich, Antony Tin, Shifra Krinshpun, Raheleh Salari, Carly Bess Scalise, Rosalyn Ram, Meenakshi Malhotra, Harini Ravi, Himanshu Sethi, Stephanie Sanchez, Robert Tanner Hagelstrom, Maxim Brevnov, Matthew Rabinowitz, Solomon Moshkevich, Bernhard G. Zimmermann, Minetta C. Liu, Alexey Aleshin
Publikováno v:
Molecular Oncology, Vol 18, Iss 11, Pp 2649-2657 (2024)
Several studies have demonstrated the prognostic value of circulating tumor DNA (ctDNA); however, the correlation of mean tumor molecules (MTM)/ml of plasma and mean variant allele frequency (mVAF; %) with clinical parameters is yet to be understood.
Externí odkaz:
https://doaj.org/article/8b2bcff23d824c9a904d5bfa7e01ecb7
Autor:
Julia Mestre, Lorea Chaparro, Ana Manzanares, Blanca Xicoy, Lurdes Zamora, Francesc Sole, Oriol Calvete
Publikováno v:
eJHaem, Vol 5, Iss 5, Pp 1021-1027 (2024)
Abstract Introduction Germline predisposition to myeloid neoplasms can be suspected in patients younger than 50 years or when harboring mutations with a variant allele frequency (VAF) higher than 30% for point mutations in specific genes. To investig
Externí odkaz:
https://doaj.org/article/7f06d8aeae5346b4a164946323df977d
Autor:
Ruyun Gao, Ning Lou, Lin Li, Tongji Xie, Puyuan Xing, Le Tang, Jiarui Yao, Xiaohong Han, Yuankai Shi
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Introduction Identifying new biomarkers for predicting immune checkpoint inhibitors (ICIs) response in non-small cell lung cancer (NSCLC) is crucial. We aimed to assess the variant allele frequency (VAF)-related profile as a novel biomarker
Externí odkaz:
https://doaj.org/article/01d8a74ab1f0446cac8f66bf6e86e1fd
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-3 (2024)
Abstract Multiple primary malignant neoplasms are a rare disease with tumors of different histology or morphology arising in various sites. Next-generation sequencing is essential in the etiology, diagnosis, treatment, and surveillance of this diseas
Externí odkaz:
https://doaj.org/article/496397dda13c4fadb0b2731b0ce06125
Autor:
ZHANG Linglong, QI Xiaolong, KOU Zhen, RENAGULI·Abulaiti, NIE Yuling, MUHEBAIER·Abuduer, ZHAI Shunsheng, AN Li, MAO Min, LI Yan
Publikováno v:
Zhongliu Fangzhi Yanjiu, Vol 50, Iss 11, Pp 1109-1113 (2023)
Objective To investigate the correlation between ITPKB mutation's variant allele frequency (VAF) and prognosis of diffuse large B-cell lymphoma (DLBCL). Methods This study included 155 patients with DLBCL initially diagnosed in the People's Hospital
Externí odkaz:
https://doaj.org/article/bda14debe2ad414e9261a3f62eb24290
Autor:
Arda Durmaz, Valeria Visconte
Publikováno v:
eLife, Vol 13 (2024)
A new mathematical model that can be applied to both single-cell and bulk DNA sequencing data sheds light on the processes governing population dynamics in stem cells.
Externí odkaz:
https://doaj.org/article/14b8323392434634bc825a071f1e90a3
Autor:
Huanying Ren, Minglin Hong, Jingyi Feng, Zhuanghui Hao, Xian Chen, Fengting Liang, Wei Wei, Xuelan Liang, Hongwei Wang, Xiuhua Chen
Publikováno v:
Biomolecules & Biomedicine (2024)
In this study, we analyzed GATA2 mutations (GATA2mut) and co-mutations in 166 Chinese patients with cytogenetically normal acute myeloid leukemia. This was done through targeted next-generation sequencing of 34 genes associated with myeloid leukemia.
Externí odkaz:
https://doaj.org/article/ef0004cc267e4c25974894977b27b49a
Autor:
Xian Chen, Chuchu Tian, Zhuanghui Hao, Lingang Pan, Minglin Hong, Wei Wei, Daniel Muteb Muyey, Hongwei Wang, Xiuhua Chen
Publikováno v:
Cancer Medicine, Vol 12, Iss 9, Pp 10340-10350 (2023)
Abstract To refine the biological and prognostic significance of DNMT3A mutations in acute myeloid leukemia (AML), we assessed the impact of DNMT3A variant allele frequency (VAF) and its comutations in this study. Using targeted next‐generation seq
Externí odkaz:
https://doaj.org/article/88a768f1e89a44f196fb50c7c98c5e3b
Publikováno v:
Hematology, Vol 27, Iss 1, Pp 902-908 (2022)
Objective Calreticulin (CALR) mutations have been identified as driver mutations in a quarter of patients with essential thrombocythaemia (ET) and primary myelofibrosis (PMF), which are subgroups of myeloproliferative neoplasms (MPNs). A 52-bp deleti
Externí odkaz:
https://doaj.org/article/4853e2cb2c38476abcfb36a24611a98e