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Immunodominant surface epitopes power immune evasion in the African trypanosome

Autor: C. E. Stebbins, Francisco Aresta-Branco, G. Triller, E. P. Vlachou, F. N. Papavasiliou, R. Blatnik, A. Gkeka, Mirjana Lilic, Brian T. Chait, Thomas Ruppert, Kathryn Perez, Paul Dominic B. Olinares

The African trypanosome survives the immune response of its mammalian host by antigenic variation of its major surface antigen (the Variable Surface Glycoprotein, or VSG). Here we describe the antibody repertoires elicited by different VSGs. We show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2bdbf12364ab8122de6ba29c66e661ab
https://doi.org/10.1101/2021.07.20.453071

Mice immunization with Trypanosoma brucei gambiense translationally controlled tumor protein modulates immunoglobulin and cytokine production, as well as parasitaemia and mice survival after challenge with the parasite

Autor: Eleonore Tour, Valérie Rodrigues, Anne Geiger, Géraldine Bossard

Publikováno v: Infection, Genetics and Evolution
Infection, Genetics and Evolution, Elsevier, 2021, 87, pp.104636. ⟨10.1016/j.meegid.2020.104636⟩
Infection, Genetics and Evolution, 2021, 87, pp.104636. ⟨10.1016/j.meegid.2020.104636⟩

International audience; Fighting trypanosomiasis with an anti-trypanosome vaccine is ineffective, the parasite being protected by a Variable Surface Glycoprotein (VSG) whose structure is modified at each peak of parasitaemia, which allows it to escap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7434566cfdd23da778193bb3f5b9702f
http://agritrop.cirad.fr/598351/

Variable Surface Glycoprotein from Trypanosoma brucei Undergoes Cleavage by Matrix Metalloproteinases: An in silico Approach

Autor: Cláudia Jassica Gonçalves Moreno, Marcelo Silva, Taffarel Melo Torres

Publikováno v: Pathogens
Pathogens, Vol 8, Iss 4, p 178 (2019)

In order to survive as extracellular parasites in the mammalian host environment, Trypanosoma brucei has developed efficient mechanisms of immune system evasion, which include the abundant expression of a variable surface glycoprotein (VSG) coat. VSG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32261f4f6bec01bc787b4027d1385e7
http://europepmc.org/articles/PMC6963732

Trypanosoma brucei interaction with host: Mechanism of VSG release as target for drug discovery for african trypanosomiasis

Autor: Moreno, Cláudia Jassica Gonçalves, Temporão, Adriana, Torres, Taffarel, Silva, Marcelo Sousa

This research was funded by GHTM-UID/multi/04413/2013 (FCT-Portugal) and Grant number 019/2013 (Capes-Brazil). The protozoan Trypanosoma brucei, responsible for animal and human trypanosomiasis, has a family of major surface proteases (MSPs) and phos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1437::e7b27e13f04c92c920c0ab85bb4d8ade
https://hdl.handle.net/10362/116745