Treatment with decitabine induces the expression of stemness markers, PD-L1 and NY-ESO-1 in colorectal cancer: potential for combined chemoimmunotherapy

Autor: Nassiba Taib, Maysaloun Merhi, Varghese Inchakalody, Sarra Mestiri, Shereena Hydrose, Karama Makni-Maalej, Afsheen Raza, Fairooz Sahir, Fouad Azizi, Parveen B. Nizamuddin, Queenie Fernandes, Zeenath Safira K. M. Yoosuf, Salam Almoghrabi, Lobna Al-Zaidan, Alaaeldin Shablak, Shahab Uddin, Cristina Maccalli, Mohammed Ussama Al Homsi, Said Dermime

Publikováno v: Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-17 (2023)

Abstract Background The mechanism of tumor immune escape and progression in colorectal cancer (CRC) is widely investigated in-vitro to help understand and identify agents that might play a crucial role in response to treatment and improve the overall

Externí odkaz: https://doaj.org/article/cf34d2e9082d425795f85ed590a413a3

Emerging dynamics pathways of response and resistance to PD-1 and CTLA-4 blockade: tackling uncertainty by confronting complexity

Autor: Allan Relecom, Maysaloun Merhi, Varghese Inchakalody, Shahab Uddin, Darawan Rinchai, Davide Bedognetti, Said Dermime

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-19 (2021)

Abstract Immune checkpoint inhibitors provide considerable therapeutic benefit in a range of solid cancers as well as in a subgroup of hematological malignancies. Response rates are however suboptimal, and despite considerable efforts, predicting res

Externí odkaz: https://doaj.org/article/04129910aa8f4e70a5800946c4b6eaaf

736 Treatment with decitabine (DAC) induces the expression of stemness markers, PD-L1 and NY-ESO-1 in colorectal cancer

Autor: Said Dermime, Cristina Maccalli, Maysaloun Merhi, Afsheen Raza, Sarra Mestiri, Shahab Uddin, Varghese Inchakalody, Nassiba Taib, Mohammed Ussama AlHomsi

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

Externí odkaz: https://doaj.org/article/041d6a74b97149c0839f597f11d2cb3e

The complex network of transcription factors, immune checkpoint inhibitors and stemness features in colorectal cancer: A recent update

Autor: Maysaloun Merhi, Fareed Ahmad, Nassiba Taib, Varghese Inchakalody, Shahab Uddin, Alaaeldin Shablak, Said Dermime

Publikováno v: Seminars in Cancer Biology. 89:1-17

Cancer immunity is regulated by several mechanisms that include co-stimulatory and/or co-inhibitory molecules known as immune checkpoints expressed by the immune cells. In colorectal cancer (CRC), CTLA-4, LAG3, TIM-3 and PD-1 are the major co-inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f324d54054391b3764b6eb8591de4123
https://doi.org/10.1016/j.semcancer.2023.01.001

Contributors

Autor: Megha Bhat Agni, Fares Al-Ejeh, Amjad Ali, Mariam Al-Muftah, Taís Aparecida Alvarenga, Lobna Al-Zaidan, K.R. Anu, Farha Anwer, Maryum Arif, Hayeqa Shahwar Awan, Anindya Bandyopadhyay, Katarina Baralić, Bruno Henrique Groenner Barbosa, Debmalya Barh, Christopher Barnes, Amina Basheer, Takwa Bedhiafi, Tulika Bhardwaj, Dragica Bozic, Elenice Valentim Carmona, Subhash Chandra, Nathaniel Chapin, Almas Chaudhry, Sarantis Chlamydas, Harry Coppock, Emmanuel Cornillot, Simone Gonçalves da Fonseca, Damodara Gowda, Subham Das, Santanu Dasgupta, Said Dermime, Daniela Fernanda dos Santos Alves, Danijela Đukić-Ćosić, Erika Christiane Marocco Duran, Queenie Fernandes, Juan Luis Fernandez-Martinez, Ana Cláudia Barbosa Honório Ferreira, Danton Diego Ferreira, Roger Frutos, Michael Garbati, Luiz Gustavo Gardinassi, Konstantinos I. Gourgoulianis, Mubashir Hassan, Pramukh Subrahmanya Hegde, Varghese Inchakalody, Alex Joseph, Tushar Joshi, Nagesh Kancharla, Bineypreet Kaur, Jaspreet Kaur, Adithi Kellarai, Andrzej Kloczkowski, Gustavo Barbosa Libotte, Davi Vinícius de Lima, Fran Sérgio Lobato, Abhilash Ludhiadch, Saul O. Lugo Reyes, Kenneth Lundstrom, Amit K. Maiti, Shalini Mathpal, Maysaloun Merhi, Sarra Mestiri, Mostafa M. Mohamed, Maria Helena Baena de Moraes Lopes, Dina Moustafa, Anjana Munshi, Anam Naz, Mina A. Nessiem, Mehmet Özdemir, Gustavo Mendes Platt, Sari Eka Pratiwi, Abdur Rahman, Afsheen Raza, Demóstenes Zegarra Rodríguez, Helioswilton Sales-Campos, Luis Otávio Santos, Shreya Sarkar, Björn W. Schuller, Rwik Sen, Fatima Shahid, Priyanka Sharma, Abubakar Siddique, Ammara Siddique, Pallavi Somvanshi, Camila Oliveira Silva Souza, Syeda Duaa Tahir, Nassiba Taib, Sushma Tamta, Shahab Uddin, Ayşe Rüveyda Uğur, George D. Vavougios, Maaz Waseem, Umesh Prasad Yadav, Eugenia Ch. Yiannakopoulou, Ysrafil Ysrafil, Tahreem Zaheer, Sotirios G. Zarogiannis, Katarina Živančević

Publikováno v: Omics approaches and technologies in COVID-19 ISBN: 9780323917940

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5b23328431b2ba3f22ff3b3bb0067f5
https://doi.org/10.1016/b978-0-323-91794-0.09987-x