Phosphodiesterase-5 inhibition collaborates with vaccine-based immunotherapy to reprogram myeloid cells in pancreatic ductal adenocarcinoma.

Autor: Gross NE; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center., Zhang Z; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center.; Convergence Institute., Mitchell JT; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center.; Convergence Institute.; Department of Genetic Medicine., Charmsaz S; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center., Hernandez AG; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center., Coyne EM; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center., Shin SM; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center., Vargas Carvajal DC; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center., Sidiropoulos DN; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center.; Convergence Institute., Cho Y; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center., Mo G; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center., Yuan X; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center.; Convergence Institute., Cannon C; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center.; Convergence Institute., Suresh Babu J; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center., Lyman MR; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center., Armstrong T; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center., Kagohara LT; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center.; Convergence Institute., Bever KM; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center.; Bloomberg-Kimmel Institute for Cancer Immunotherapy; and., Le DT; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center.; Bloomberg-Kimmel Institute for Cancer Immunotherapy; and., Jaffee EM; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center.; Convergence Institute.; Bloomberg-Kimmel Institute for Cancer Immunotherapy; and., Fertig EJ; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center.; Convergence Institute.; Department of Genetic Medicine.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Applied Mathematics and Statistics, Johns Hopkins University Whiting School of Engineering, Baltimore, Maryland, USA., Ho WJ; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center.; Convergence Institute.

Publikováno v: JCI insight [JCI Insight] 2024 Aug 06; Vol. 9 (18). Date of Electronic Publication: 2024 Aug 06.