Feasibility of comparing medical management and surgery (with neurosurgery or stereotactic radiosurgery) with medical management alone in people with symptomatic brain cavernoma – protocol for the Cavernomas: A Randomised Effectiveness (CARE) pilot trial

Autor: Khalid Hamandi, Julie Woodfield, Smriti Agarwal, Richard Edwards, John Williamson, Ravindran Visagan, Rustam Al-Shahi Salman, Howard Brydon, Diederik Bulters, Dawn Hennigan, Paul Leach, Conor Mallucci, Nitin Mukerji, Marios Papadopoulos, Nicholas Ross, Martin Tisdall, Carole Turner, Shungu Ushewokunze, Raghu Vindlacheruvu, Paul Brennan, Phil White, Sophie Hunter, Karen Coy, Julia Wade, James Stewart, Tom Hughes, Laura Forsyth, Kirsty Harkness, David White, Rupal Shah, Sanjay Bhate, Neil Kitchen, Peter J Hutchinson, Emanuel Cirstea, Ramesh Nair, Rebecca Hall, Varduhi Cahill, Tom Hayton, Silvia Tarantino, Christin Eltze, Jack Lee, Arlo Whitehouse, Daniel Walsh, Jacqueline Stephen, Nicola Phillips, Steff Lewis, Susan Davies, Mathew Guilfoyle, Peter S Hall, Andrew Stoddart, Francesca Colombo, Emma Richards, Greg James, Sarah Illingworth, William B Lo, Andrew Bacon, Vijeya Ganesan, Sabina Patel, Aileen R Neilson, Felicia Jennings, Saba Raza-Knight, Andrew Brodbelt, Aswin Chari, Hasan Asif, Ian Kamaly-Asl, Milan Makwana, Zubair Tahir, Allan MacRaild, Grace Vassallo, Ian Anderson, Daniel Holsgrove, Carole Chambers, Sandra Williams, Francesca Spickett-Jones, Marios C Papadopoulos, John Preston, Edward White, Adel Helmy, Sarah Ali, John Reid, Daniel Brown, Louis Taylor, Christopher Uff, Patrick Grover, Azra Banaras, Linetty Makawa, Anil Israni, Richard J Edwards, William Muirhead, Daniel Brooks, Debbie Brown, Ciaran Scott Hill, Kerry Smith, Beth Atkinson, Michelle Fawcett, Sifelani Tshuma, Oliver Kennion, Jo Howe, James J M Loan, Philip Clatworthy, Claire Hudson, Rebecca Hodnett, Madalina Roman, Mary Sikaonga, Elaine Kinsella, Mario Teo, Venetia Giannakaki, James Loan, Lauren Harris, Jack Wildman, Emmanuel Chavredakis, Nihal Gurusinghe, Alex Rossdeutsch, Anthony Wiggins, Giannis Sokratous, Lucie Ferguson, Shakeelah Patel, Sonia Raj, Oishik Raha, Janneke van Beijnum, Pragnesh Bhatt, Anna Bjornson, Nicole Broomes, Alistair Bullen, Julian Cahill, Mihai Danciut, Ronneil Digpal, Ioannis Fouyas, Lauren S Harris, Sohail Majeed, Matthias Radatz, Oliver Wroe Wright, Jessica Teasdale, Michelle Coakley, Drahoslav Sokol, Chandru Kaliaperumal, Mairi MacDonald, Sarah Risbridger, Siobhan Kearney, Ellaine Bosetta, Thomas Doke, Sonny Coskuner, Christine Kamara, Jonathan Gardner, Imron Hamina, Kishor Chaudhari, Liliana Chapas, Karen Caldwell, Sarah Holland, Tamara Tajsic, Rachael Dore, Taya Anderson, Shelley Mayor, Laura O'Malley, Samantha Glover, Janice Irvine, Annika Walch, Farah Muir, Eng Tah Goh, Andrew McDarby, Michelle Bates, Rebecca Hancox, Claudia Kate Auyeung, Elizabeth Goff, Deanna Stephens, Borislava Borislavova, Ruth Worner, Sandeep Buddha, Lisa Tucker, Sandra Dymond, Andrew Mallick, Dymona McAleer, Belinda Gunning, Emma Clarkson, Cathy Stoneley, Jibril Osman Farah, Niamh Bohnacker, Rosette Marimon, Lydia Parker, Puneet Sharma, Dan Holsgrove, Danielle McLaughlan, Tracey Marsden, Kathryn Cawley, Hellen Raffalli, Imedla Mayor, Dipek Ram, Rebecca Keeping, Katie Hennessy, Ammar Kadhim, Md Moidul Islam, Manjunath Prasad, Cheryl Webster, Vicky Slater, Saffnan Mohamed, Saba Raza Knight, Terri-Louise Cromie, Allan Brown, Ruth Pennington, Charlene Campbell, Anthony Ghosh, Teresa Fitzpatrick, Mohammed Patel, Winnington Ruiz, Mirriam Taylor, Divina Anyog, Katarzyna Tluchowska, Jackson Nolasco, Kleopatra Angelopoulou, Bethany Welch, Ida Ponce, Lucy Bailey, Mia Marsden, Angelene Cope, Deepthy Blesson, Rachel Sutton, Mary Kambafwile, Jade McAndrew

Publikováno v: BMJ Open, Vol 13, Iss 8 (2023)

Introduction The top research priority for cavernoma, identified by a James Lind Alliance Priority setting partnership was ‘Does treatment (with neurosurgery or stereotactic radiosurgery) or no treatment improve outcome for people diagnosed with a

Externí odkaz: https://doaj.org/article/df389aa5a29f4557ac19c817e505e753

Machine learning approaches for imaging‐based prognostication of the outcome of surgery for mesial temporal lobe epilepsy

Autor: Benjamin Sinclair, Varduhi Cahill, Jarrel Seah, Andy Kitchen, Lucy E. Vivash, Zhibin Chen, Charles B. Malpas, Marie F. O'Shea, Patricia M. Desmond, Rodney J. Hicks, Andrew P. Morokoff, James A. King, Gavin C. Fabinyi, Andrew H. Kaye, Patrick Kwan, Samuel F. Berkovic, Meng Law, Terence J. O'Brien

Publikováno v: Epilepsia. 63:1081-1092

Around 30% of patients undergoing surgical resection for drug-resistant mesial temporal lobe epilepsy (MTLE) do not obtain seizure freedom. Success of anterior temporal lobe resection (ATLR) critically depends on the careful selection of surgical can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4944c0c1a5950180d473d3293a92c6ae
https://doi.org/10.1111/epi.17217

Metabolic patterns and seizure outcomes following anterior temporal lobectomy

Autor: Salvatore U Berlangieri, Terence J. O'Brien, Samuel F. Berkovic, Charles B Malpas, Andrew H. Kaye, Andrew P. Morokoff, Christopher C. Rowe, James King, Patrick Kwan, Gavin Fabinyi, Anne M. McIntosh, Zhibin Chen, Marie F. O'shea, Lucy Vivash, Sarah J. Wilson, Varduhi Cahill, Patricia Desmond, Rodney J. Hicks, Benjamin Sinclair

Publikováno v: Annals of Neurology. 85:241-250

OBJECTIVE: We investigated the relationship between the interictal metabolic patterns, the extent of resection of 18 F-fluorodeoxyglucose positron emission tomography (18 FDG-PET) hypometabolism, and seizure outcomes in patients with unilateral drug-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::773c3dc477938049b6e28bdd816db749
https://doi.org/10.1002/ana.25405

149 Mesial temporal lobe epilepsy with amygdala enlargement: a phenotype of autoimmune epilepsy?

Autor: Hannah Glasse, Angus Hotchkies, Matt Bailey, Rajiv Mohanraj, Varduhi Cahill, Paul Cooper

Publikováno v: Journal of Neurology, Neurosurgery & Psychiatry. 93:A55.4-A56

BackgroundMesial temporal lobe epilepsy with amygdala enlargement (MTLE-AE) is a relatively newly described subtype of focal epilepsy. The aetiology of MTLE-AE remains unclear. We investigated the prevalence of antibodies to neuronal antigens in a co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a01b05862b8f7339c67f388d6fd30528
https://doi.org/10.1136/jnnp-2022-abn.179

072 Diffuse Astrocytoma as a radiological mimic of Neuro-Behcet’s Disease

Autor: Christopher Leahy, Philip McNulty, Amit Herwadkar, Pietro D’Urso, Varduhi Cahill

Publikováno v: Journal of Neurology, Neurosurgery & Psychiatry. 93:A123.1-A123

We present a case of diffuse astrocytoma mimicking the radiological features of Neuro-Behcet’s disease. A 61 year old man presented with a progressive asymmetric brainstem syndrome (left>right). Examination of cranial nerves revealed a left lateral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51594a3f86305017009972e62b600ff1
https://doi.org/10.1136/jnnp-2022-abn.397