The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection.

Autor: Richards CM; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA., Jabs S; Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany., Qiao W; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA., Varanese LD; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA., Schweizer M; Department of Electron Microscopy, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Mosen PR; Institute for Biochemistry and Molecular Biology, Medical Faculty, Rheinische Friedrich-Wilhelms-University of Bonn, Bonn, Germany., Riley NM; Department of Chemistry, Stanford University, Stanford, CA, USA., Klüssendorf M; Department of Osteology and Biomechanics, Cell Biology of Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Zengel JR; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA., Flynn RA; Stem Cell Program, Boston Children's Hospital, Boston, MA, USA.; Stem Cell and Regenerative Biology Department, Harvard University, Cambridge, MA, USA., Rustagi A; Division of Infectious Disease and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Widen JC; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Peters CE; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA., Ooi YS; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore., Xie X; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA., Shi PY; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA., Bartenschlager R; Department of Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany.; Division Virus-Associated Carcinogenesis, German Cancer Research Center (DKFZ), Heidelberg, Germany., Puschnik AS; Chan Zuckerberg Biohub, San Francisco, CA, USA., Bogyo M; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Bertozzi CR; Department of Chemistry, Stanford University, Stanford, CA, USA.; Howard Hughes Medical Institute, Stanford, CA, USA., Blish CA; Division of Infectious Disease and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Winter D; Institute for Biochemistry and Molecular Biology, Medical Faculty, Rheinische Friedrich-Wilhelms-University of Bonn, Bonn, Germany., Nagamine CM; Department of Comparative Medicine, Stanford University School of Medicine, Stanford, CA, USA., Braulke T; Department of Osteology and Biomechanics, Cell Biology of Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Carette JE; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2022 Oct 07; Vol. 378 (6615), pp. eabn5648. Date of Electronic Publication: 2022 Oct 07.