Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Vara Prasad Manchem"'
1
Akademický článek
Peripheral reduction of FGFR4 with antisense oligonucleotides increases metabolic rate and lowers adiposity in diet-induced obese mice.
Autor: Xing Xian Yu, Lynnetta M Watts, Vara Prasad Manchem, Kaushik Chakravarty, Brett P Monia, Michael L McCaleb, Sanjay Bhanot
Publikováno v: PLoS ONE, Vol 8, Iss 7, p e66923 (2013)
Obesity is a primary risk factor for multiple metabolic disorders. Many drugs for the treatment of obesity, which mainly act through CNS as appetite suppressants, have failed during development or been removed from the market due to unacceptable adve
Externí odkaz: https://doaj.org/article/4d1219a3b2e94f63b0bb77e501d3963a
Zobrazit plný text záznamu
3
Design, Synthesis, and Structure−Activity Relationships of Novel Insulin Receptor Tyrosine Kinase Activators
Autor: Vara Prasad Manchem, Ira D. Goldfine, Wayne R. Spevak, Cristina P. Cristobal, Robert T. Lum, Louise Robinson, James G. Keck, Songyuan Shi, Park Jeong Weong, Sandhya Rao, Joseph L. Evans, Yukiharu Matsumoto, Macsata Robert W, Mingshan Cheng, Steven R. Schow
Publikováno v: Journal of Medicinal Chemistry. 51:6173-6187
A novel series of symmetrical ureas of [(7-amino(2-naphthyl))sulfonyl]phenylamines were designed, synthesized, and tested for their ability to increase glucose transport in mouse 3T3-L1 adipocytes, a surrogate readout for activation of the insulin re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::969c70ebf1c07c2caf46005c0f3beeec
https://doi.org/10.1021/jm800600v
Zobrazit plný text záznamu
4
Reduction of Low Molecular Weight Protein-tyrosine Phosphatase Expression Improves Hyperglycemia and Insulin Sensitivity in Obese Mice
Autor: Amber R. Rivard, Xing Xian Yu, Sanjay K. Pandey, Thomas A. Leedom, Robert Mckay, Lynnetta Watts, Laura Samadzadeh, Kyle W. Sloop, Vara Prasad Manchem, M. Dodson Michael, Sanjay Bhanot, Brett P. Monia
Publikováno v: Journal of Biological Chemistry. 282:14291-14299
To investigate the role of low molecular weight protein-tyrosine phosphatase (LMW-PTP) in glucose metabolism and insulin action, a specific antisense oligonucleotide (ASO) was used to reduce its expression both in vitro and in vivo. Reduction of LMW-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8f293f55456a77c2d8af60c058135e
https://doi.org/10.1074/jbc.m609626200
Zobrazit plný text záznamu
5
Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance
Autor: Blas A. Guigni, François R Jornayvaz, Violeta B. Popov, Emin O. Akgul, Vara Prasad Manchem, Sanjay Bhanot, Dongyan Zhang, Kitt Falk Petersen, Abulizi Abudukadier, Shoichi Kanda, Gerald I. Shulman, Varman T. Samuel, Michael J. Jurczak, Sachin Majumdar
Publikováno v: FASEB Journal, Vol. 30, No 3 (2016) pp. 1207-1217
Although mutations in the Wnt/β-catenin signaling pathway are linked with the metabolic syndrome and type 2 diabetes in humans, the mechanism is unclear. High-fat-fed male C57BL/6 mice were treated for 4 wk with a 2′-O-methoxyethyl chimeric antise
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a30532fc6de70f91e0cb52795df12b23
https://pubmed.ncbi.nlm.nih.gov/26644352
Zobrazit plný text záznamu
6
Small Molecule Activators of the Insulin Receptor: Potential New Therapeutic Agents for the Treatment of Diabetes Mellitus
Autor: Edgardo Laborde, Vara Prasad Manchem
Publikováno v: Current Medicinal Chemistry. 9:2231-2242
Diabetes mellitus refers to a spectrum of syndromes characterized by abnormally high levels of glucose in blood. These syndromes are associated with an absolute (Type 1 diabetes) or relative (Type 2 diabetes) deficiency of insulin, coupled with varyi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::720215140ffd4118b719f102ae881540
https://doi.org/10.2174/0929867023368665
Zobrazit plný text záznamu
8
A Novel Small Molecule That Directly Sensitizes the Insulin Receptor In Vitro and In Vivo
Autor: Songyuan Shi, Schow Steven R, Hugo O. Villar, Deborah K. Toavs, Kozlowski Michael R, Vara Prasad Manchem, Michael M. Wick, Wayne R. Spevak, Ronald A. Kohanski, Lum Robert T, Edgardo Laborde, Ira D. Goldfine, Cristina P. Cristobal
Publikováno v: Diabetes. 50:824-830
Insulin resistance, an important feature of type 2 diabetes, is manifested as attenuated insulin receptor (IR) signaling in response to insulin binding. A drug that promotes the initiation of IR signaling by enhancing IR autophosphorylation should, t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f103fbd5946f762ca4747a7b04943945
https://doi.org/10.2337/diabetes.50.4.824
Zobrazit plný text záznamu
9
Peripheral Reduction of FGFR4 with Antisense Oligonucleotides Increases Metabolic Rate and Lowers Adiposity in Diet-Induced Obese Mice
Autor: Lynnetta Watts, Xing Xian Yu, Vara Prasad Manchem, Brett P. Monia, Sanjay Bhanot, Kaushik Chakravarty, Michael L. McCaleb
Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 7, p e66923 (2013)
Obesity is a primary risk factor for multiple metabolic disorders. Many drugs for the treatment of obesity, which mainly act through CNS as appetite suppressants, have failed during development or been removed from the market due to unacceptable adve
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f283f0ec3936a2d2281847ffae8fd50d
http://europepmc.org/articles/PMC3726752
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje