Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Vaqar, Sharief"'
Autor:
Colin, Zhang, Meizhong, Xu, Chunhong, He, Jincong, Zhuo, David M, Burns, Ding-Quan, Qian, Qiyan, Lin, Yun-Long, Li, Lihua, Chen, Eric, Shi, Costas, Agrios, Linkai, Weng, Vaqar, Sharief, Ravi, Jalluri, Yanlong, Li, Peggy, Scherle, Sharon, Diamond, Deborah, Hunter, Maryanne, Covington, Cindy, Marando, Richard, Wynn, Kamna, Katiyar, Nancy, Contel, Kris, Vaddi, Swamy, Yeleswaram, Gregory, Hollis, Reid, Huber, Steve, Friedman, Brian, Metcalf, Wenqing, Yao
Publikováno v:
SSRN Electronic Journal.
11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) has been identified as the primary enzyme responsible for the activation of hepatic cortisone to cortisol in specific peripheral tissues resulting in the concomitant antagonism of insulin action within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3692552a04b6f880ed62ecd30b202590
https://doi.org/10.2139/ssrn.4056120
https://doi.org/10.2139/ssrn.4056120
Autor:
Yun-Long Li, Brian Metcalf, Richard Wynn, Mark Stow, Yanlong Li, Qiyan Lin, Kamna Katiyar, Eric Shi, Costas Agrios, Vaqar Sharief, Lingkai Weng, Reid Huber, Steven M. Friedman, Peggy A. Scherle, Timothy Burn, Xiangdong Liu, Meizhong Xu, Gregory F. Hollis, Colin Zhang, David M. Burns, Dawn Ellis, Robert Newton, Phillip Liu, Cindy Marando, Maryanne B. Covington, Chunhong He, M.C. Hillman, Gengjie Yang, Jincong Zhuo, Mark Rupar, Ding-Quan Qian, Wenqing Yao, Kenneth Abremski, Jodi D. Bradley
Publikováno v:
Cancer Biology & Therapy. 5:657-664
Overexpression and activating mutations of ErbB family members have been implicated in the development and progression of a variety of tumor types. Cleavage of the HER2 receptor by an as yet unidentified ectodomain sheddase has been shown to liberate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c435ae0c30ea356f73c04aba227fa78d
https://doi.org/10.4161/cbt.5.6.2708
https://doi.org/10.4161/cbt.5.6.2708
Autor:
Greg Hollis, Changsheng Zheng, Hao Feng, Mei Li, Peggy Scherle, Taisheng Huang, Joseph Glenn, Chu-Biao Xue, Kris Vaddi, Lixin Shao, Brian Metcalf, Tom Emm, Nancy Contel, Ke Zhang, Ganfeng Cao, Dilip P. Modi, Lou Storace, Anlai Wang, Sharon Diamond, Robert C. Newton, Chen Lihua, Steven Friedman, Rajan Anand, Vaqar Sharief, Lingquan Kong, Hiroyuki Tanaka, Meloni David, Maryanne Covington, Michael Xia, Laurine G. Galya, Robinson Darius J, Qi Han, Swamy Yeleswaram, Yingxin Zhang
Publikováno v:
ACS medicinal chemistry letters. 2(6)
We report the identification of 13 (INCB3284) as a potent human CCR2 (hCCR2) antagonist. INCB3284 exhibited an IC50 of 3.7 nM in antagonism of monocyte chemoattractant protein-1 binding to hCCR2, an IC50 of 4.7 nM in antagonism of chemotaxis activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cdd928778e1596e752bde06658b5662
https://pubmed.ncbi.nlm.nih.gov/24900329
https://pubmed.ncbi.nlm.nih.gov/24900329
Publikováno v:
Energy & Fuels. 5:274-280
Alkylindoles have been implicated in the formation of insolubles and color during ambient storage of diesel fuels containing light cycle oil. Oxidatively reactive diesel fuels are characterized by the inability of hindered phenol antioxidants to sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::948668263c64fc7e34951ebd506ffd70
https://doi.org/10.1021/ef00026a009
https://doi.org/10.1021/ef00026a009
Publikováno v:
The Journal of organic chemistry. 67(26)
Potassium tert-butoxide triggers the chemoselective cyclization between nitrile anions and remote, enolizable carbonyl groups, despite the acidity difference favoring enolate formation and addition to the nitrile group. Domino deprotonation, cyclizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fecf0679427dfcdb713f36454588940a
https://pubmed.ncbi.nlm.nih.gov/12492346
https://pubmed.ncbi.nlm.nih.gov/12492346