Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Vapurcuyan A"'
Autor:
Huth, Felix, Domange, Norbert, Poller, Birk, Vapurcuyan, Arpine, Durrwell, Alexandre, Hanna, Imad D., Faller, Bernard
Publikováno v:
In Journal of Pharmaceutical Sciences June 2021 110(6):2562-2569
Autor:
Birk Poller, Imad D. Hanna, Felix Huth, Norbert Domange, Arpine Vapurcuyan, Alexandre Durrwell, Bernard Faller
Publikováno v:
Journal of pharmaceutical sciences. 110(6)
The estimation of the extent of absorption of drug candidates intended for oral drug delivery is an important selection criteria in drug discovery. The use of cell-based transwell assays examining flux across cell-monolayers (e.g., Caco-2 or MDCK cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24dade811aee279fb3567e6163e911c
https://pubmed.ncbi.nlm.nih.gov/33539870
https://pubmed.ncbi.nlm.nih.gov/33539870
Autor:
Jin Chen, Gangadhar Sunkara, Kenneth Kulmatycki, Sam Rebello, Tapan K. Majumdar, Arpine Vapurcuyan, Aishwarya Movva, Atish Salunke, Dan Meyers, Imad Hanna, Adrienne Natrillo
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 53:345-355
Objective An in vitro drugdrug interaction (DDI) study was performed to assess the potential for pradigastat to inhibit breast cancer resistance protein (BCRP), organic anion-transporting polypeptide (OATP), and organic anion transporter 3 (OAT3) tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dacb2bb739fc3e6a516b5f03b746a33c
https://doi.org/10.5414/cp202275
https://doi.org/10.5414/cp202275
Autor:
John A Davis, Natalya Alexander, Phi Tran, Arpine Vapurcuyan, Bing Zhu, Imad Hanna, Matthew H. Crouthamel, Adrienne Natrillo
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 48(3)
1. The potential for drug–drug interactions of LCZ696 (a novel, crystalline complex comprising sacubitril and valsartan) was investigated in vitro. 2. Sacubitril was shown to be a highly permeable P-glycoprotein (P-gp) substrate and was hydrolyzed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec3fe884368174bea0c950bfe38f0766
https://pubmed.ncbi.nlm.nih.gov/28281384
https://pubmed.ncbi.nlm.nih.gov/28281384
Autor:
J. Larry Renfro, Mansong Li, Sonda L. Parker, Arpine Vapurcuyan, Ryan M. Pelis, Leslie Ingraham, Imad Hanna
Publikováno v:
Molecular Pharmacology. 86:86-95
The purpose of the present study was to determine whether a physiologic plasma concentration of α-ketoglutarate (αKG) influences the kinetic interaction of ligands with organic anion transporter 1 (OAT1). The effect of extracellular αKG on the kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00bc6d3c81d2c9f229e7d19b1b5ee2c4
https://doi.org/10.1124/mol.114.091777
https://doi.org/10.1124/mol.114.091777
Akademický článek
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Autor:
Sam Rebello, Imad Hanna, Sam Hariry, Sally Zhao, Natalya Alexander, Arpine Vapurcuyan, Venkateswar Jarugula, Marion Dahlke
Publikováno v:
European Journal of Clinical Pharmacology. 68:697-708
To conduct a mechanistic investigation of the interaction between aliskiren and grapefruit juice in healthy subjects.Twenty-eight subjects received an oral dose of aliskiren 300 mg (highest recommended clinical dose) with 300 mL of either water or gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891248ada23e84889918be2450058cda
https://doi.org/10.1007/s00228-011-1167-4
https://doi.org/10.1007/s00228-011-1167-4
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 40(3)
The organic anion transporters 1 and 3 (OAT1 and OAT3) and organic cation transporter 2 (OCT2) are important for renal tubular drug secretion. In contrast, evidence for OAT2 expression in the human kidney is limited, and its role in renal drug transp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b130faf736cdfb5f9e390c24313f43d7
https://pubmed.ncbi.nlm.nih.gov/22190696
https://pubmed.ncbi.nlm.nih.gov/22190696
Akademický článek
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Akademický článek
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