Structure elucidation of a human melanocortin-4 receptor specific orthosteric nanobody agonist.

Autor: Fontaine T; Confo Therapeutics N.V, Ghent, Belgium., Busch A; Confo Therapeutics N.V, Ghent, Belgium., Laeremans T; Confo Therapeutics N.V, Ghent, Belgium., De Cesco S; Confo Therapeutics N.V, Ghent, Belgium., Liang YL; Confo Therapeutics N.V, Ghent, Belgium., Jaakola VP; Confo Therapeutics N.V, Ghent, Belgium., Sands Z; Confo Therapeutics N.V, Ghent, Belgium., Triest S; Confo Therapeutics N.V, Ghent, Belgium., Masiulis S; Materials and Structural Analysis, Thermo Fisher Scientific, Eindhoven, The Netherlands., Dekeyzer L; Confo Therapeutics N.V, Ghent, Belgium., Samyn N; Confo Therapeutics N.V, Ghent, Belgium., Loeys N; Confo Therapeutics N.V, Ghent, Belgium., Perneel L; Confo Therapeutics N.V, Ghent, Belgium., Debaere M; Confo Therapeutics N.V, Ghent, Belgium., Martini M; Confo Therapeutics N.V, Ghent, Belgium., Vantieghem C; Confo Therapeutics N.V, Ghent, Belgium., Virmani R; Confo Therapeutics N.V, Ghent, Belgium., Skieterska K; Confo Therapeutics N.V, Ghent, Belgium., Staelens S; Confo Therapeutics N.V, Ghent, Belgium., Barroco R; Confo Therapeutics N.V, Ghent, Belgium., Van Roy M; Confo Therapeutics N.V, Ghent, Belgium., Menet C; Confo Therapeutics N.V, Ghent, Belgium. christel.menet@confotherapeutics.com.

Publikováno v: Nature communications [Nat Commun] 2024 Oct 01; Vol. 15 (1), pp. 7029. Date of Electronic Publication: 2024 Oct 01.