Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Vanthea Nhem"'
Autor:
Robert Johannes Lütjens, Andrés A. Trabanco, Vanthea Nhem, Yves Thollon, Géraldine Poulain, Philippe Cluzeau, Rocco Furnari, Jean-Philippe Rocher, Nadia Behaj, Gregor James Macdonald, Hassan Julien Imogai, Hilde Lavreysen, José María Cid, Terry Patrick Finn, Nicolas Poirier, Sonia Poli, Emmanuel Le Poul, David D’Addona, José Ignacio Andrés, Alexandre Raux, Guillaume Albert Jacques Duvey
Publikováno v:
MedChemComm. 2:132-139
A series of N-propyl-5-substituted isoquinolones was identified as positive allosteric modulators (PAM) of metabotropic glutamate receptor 2 (mGluR2) via high-throughput screening (HTS). The subsequent synthesis and preliminary SAR exploration that l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90dd920ad8ee7d2db1f770f049686fe6
https://doi.org/10.1039/c0md00200c
https://doi.org/10.1039/c0md00200c
Autor:
Philippe Cluzeau, Hassan Julien Imogai, Mark Epping-Jordan, Alexandre Raux, Guillaume Albert Jacques Duvey, Jean-Philippe Rocher, Gregor James Macdonald, José María Cid, Ana Isabel de Lucas, Juan Antonio Vega, Vanthea Nhem, Francis Derouet, Gary Tresadern, Andrés A. Trabanco, Christelle Boléa, José Ignacio Andrés, Robert Johannes Lütjens, Daniel Oehlrich, Karim Macary, Encarnación Matesanz, Hilde Lavreysen, Terry Patrick Finn, Sonia Poli, Jessica Muller, María Lourdes Linares, Nicolas Poirier, Francoise Girard, Julen Oyarzabal, Emilie Chamelot, Emmanuel Le Poul
Publikováno v:
ACS Chemical Neuroscience. 1:788-795
The discovery and characterization of compound 48, a selective and in vivo active mGlu2 receptor positive allosteric modulator (PAM), are described. A key to the discovery was the rational exploration of the initial HTS hit 13 guided by an overlay mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f590c750783d25cc6a29610597f8f26
https://doi.org/10.1021/cn1000638
https://doi.org/10.1021/cn1000638
Autor:
Hassan Julien Imogai, Nadia Behaj, Robert Johannes Lütjens, Vanthea Nhem, Jean-Philippe Rocher, Philippe Cluzeau, Hilde Lavreysen, Gregor James Macdonald, Emmanuel Le Poul, Nicolas Poirier, David D’Addona, Alexandre Raux, José Ignacio Andrés, Guillaume Albert Jacques Duvey, Terry Patrick Finn, Yves Thollon, Géraldine Poulain, Rocco Furnari, Andrés A. Trabanco, José María Cid, Sonia Poli
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(3)
A series of N-propyl-8-chloro-6-substituted isoquinolones was identified as positive allosteric modulators of metabotropic glutamate receptor 2 (mGluR2 PAM) via high throughput screening (HTS). The subsequent synthesis and initial SAR exploration tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b178f3586c27ab8e064bbd62eb27b7bf
https://pubmed.ncbi.nlm.nih.gov/21232953
https://pubmed.ncbi.nlm.nih.gov/21232953