Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Vann P. Parker"'
Autor:
Vann P. Parker, Ernest C. Borden, David Sweedler, Karin S. Blanchard, Jennifer A. Sandberg, Lawrence M. Blatt, Nassim Usman, James A. Powell, Laurent Bellon, Arlee Kachensky, Thomas Rossing
Publikováno v:
The Journal of Clinical Pharmacology. 40:1462-1469
The pharmacokinetics and tolerability of a chemically stabilized synthetic ribozyme (ANGIOZYME ) targeting the Flt-1 VEGF receptor mRNA were evaluated in healthy volunteers. In a placebo-controlled, single-dose escalation study, ribozyme was administ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3731c43b3db54a409cbe2c537a1142fc
https://doi.org/10.1177/009127000004001217
https://doi.org/10.1177/009127000004001217
Autor:
Tom J. Parry, Karin S. Blanchard, Vann P. Parker, Florence A. Caputo, David Sweedler, Christopher D. Sproul, Douglas J. Kornbrust, James A. Powell, Laurent Bellon, Jennifer A. Sandberg, Lawrence M. Blatt
Publikováno v:
Antisense and Nucleic Acid Drug Development. 10:153-162
The potential acute toxicity of a ribozyme (ANGIOZYME) targeting the flt-1 vascular endothelial growth factor (VEGF) receptor mRNA was evaluated in cynomolgus monkeys following i.v. infusion or s.c. injection. ANGIOZYME was administered as a 4-hour i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4412205fe955f25f37715f41354e64
https://doi.org/10.1089/oli.1.2000.10.153
https://doi.org/10.1089/oli.1.2000.10.153
Autor:
Keith Langley, Vann P. Parker, Ya-Chen Ko, Shirley M. Taylor, Yves A. DeClerck, Elizabeth A. Mendiaz
Publikováno v:
Biochemical and Biophysical Research Communications. 236:100-105
We have generated a C-terminally-truncated form of recombinant tissue inhibitor of metalloproteinases-2 (designated rTIMP-2 delta) in which the region of the inhibitor extending from residue 128 to 194 and including 3 of the 6 disulfide bonds is dele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36391d3e199e8d9c8082661c03844e4f
https://doi.org/10.1006/bbrc.1997.6859
https://doi.org/10.1006/bbrc.1997.6859
Autor:
Linda O. Narhi, John S. Philo, Tom Horan, Vann P. Parker, Tsutomu Arakawa, Jie Wen, Andy Garcia
Publikováno v:
Biochemistry. 35:4886-4896
Granulocyte-colony stimulating factor (G-CSF) binds to a specific cell surface receptor and induces signals for growth and differentiation in cells of granulocyte hematopoietic lineage. In order to understand how G-CSF binding initiates signals into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b043a410f9c2537d80bb7b318e661d0d
https://doi.org/10.1021/bi9525841
https://doi.org/10.1021/bi9525841
Autor:
Meredith G. Schwartz, Christi L. Clogston, Vann P. Parker, Larry Bennett, Jette Wypych, Hsieng Sen Lu, Keith Langley, Timothy D. Bartley, Virginia C. Broudy
Publikováno v:
Blood. 85:66-73
c-kit encodes the transmembrane receptor tyrosine kinase (Kit) for the recently described ligand stem cell factor (SCF). We have developed an enzyme-linked immunosorbent assay for measuring soluble human Kit and we have used the assay to show high le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e9bedd261a7607beb3f47c3a9bf2da8
https://doi.org/10.1182/blood.v85.1.66.bloodjournal85166
https://doi.org/10.1182/blood.v85.1.66.bloodjournal85166
Autor:
Y. Sun, E. Hsu, Vann P. Parker, Y.P. Yung, L. Selander, C. Xie, J.D. Skrine, Hsieng Sen Lu, Geraldine Trail, Yang Li, E. Choi, M.M. Hokom, A. Hornkohl, D. Trollinger, R. Pacifici, J. Crouse, Babru B Samal, W. Xu, John R. Shutter, Merrie J. Johnson, H. Chute, Frederick W. Jacobsen, Francis Hall Martin, L. Sieu, Mickey C.T. Hu, D. Padilla, Rita Basu, G. Elliott, R.-Y. Hsu, S. Cole, Sidney Vaughn Suggs, A. Garcia, R.A. Rosselman, C. Clogston, P Hunt, L. Simonet, L.A. Merewether, I. Ponting, T. Covey, T.D. Bartley, Jennifer McNinch, M. Pangelinan, Chris Saris, R. Izumi, Duanzhi Wen, S. Swift, J.L. Nichol, J. Biron, J. Del Castillo, V L Mar, Jakob M. Bogenberger, Ming-Shi Chang, H. Lin
Publikováno v:
Cell. 77:1117-1124
A novel megakaryocyte growth and development factor (MGDF) has been identified in aplastic canine plasma, and its cDNAs have been cloned from canine, murine, and human sources. Purified canine MGDF isolated by procedures involving MpI receptor affini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2daf8471926f22d573339180f4b65a1c
https://doi.org/10.1016/0092-8674(94)90450-2
https://doi.org/10.1016/0092-8674(94)90450-2
Autor:
Hsieng Sen Lu, Subhash B. Karkare, Sylvia Hu, Xiao-Dong Liu, Krisztina M. Zsebo, Steven G. Ogden, Kristina Swiderek, Christi L. Clogston, Vann P. Parker, Terry D. Lee, David C. Chang, Keith Langley, Avantika C. Patel, David W. Brankow, Robert F. Baltera, Jette Wypych
Publikováno v:
Archives of Biochemistry and Biophysics. 298:150-158
This report describes the structure of soluble human stem cell factor isolated from the conditioned medium of Chinese hamster ovary (CHO) cells transfected with stem cell factor (SCF) cDNA, which encodes a leader sequence plus 248 additional amino ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d103a777a2bcae34133e2f02a7d7ba
https://doi.org/10.1016/0003-9861(92)90106-7
https://doi.org/10.1016/0003-9861(92)90106-7
Autor:
Keith E. Langley, Jette Wypych, Elizabeth A. Mendiaz, Christi L. Clogston, Vann P. Parker, Douglas H. Farrar, Mark O. Brothers, Vasuki N. Satygal, Ian Leslie, Neal C. Birkett, Kent A. Smith, Robert F. Baltera, David E. Lyons, Jeffery M. Hogan, Craig Crandall, Thomas C. Boone, Joseph A. Pope, Subhash B. Karkare, Krisztina M. Zsebo, Raj K. Sachdev, Hsieng S. Lu
Publikováno v:
Archives of Biochemistry and Biophysics. 295:21-28
Stem cell factor (SCF) is a novel, early-acting hematopoietic factor. It was isolated from the medium of a rat cell line in a soluble, processed form (Zsebo et al., 1990, Cell 63, 195). The cloned human and rat genes encode the soluble form plus addi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0bb119dbb2ffc13a57911387969401c
https://doi.org/10.1016/0003-9861(92)90482-c
https://doi.org/10.1016/0003-9861(92)90482-c
Autor:
C. Fred Morris, Krisztina M. Zsebo, Ian K. McNiece, Charles J. Herrera, Joseph A. Pope, Duanzhi Wen, Holly O. Erjavec, Eric F. Fisher, Rod Cupples, Chi Hwei Lin, Kenneth H. Okino, Jette Wypych, Neal C. Birkett, Francis Hall Martin, Ian Leslie, Vann P. Parker, Elizabeth A. Mendlaz, Raj Kumar Sachdev, Kent A. Smith, Josephine C. Flores, Avantika C. Patel, Hsieng Sen Lu, Frederick W. Jacobsen, Sidney Vaughn Suggs, Merrie J. Johnson, Jerry Ting, Keith Langley
Publikováno v:
Cell. 63:203-211
Partial cDNA and genomic clones of rat stem cell factor (SCF) have been isolated. Using probes based on the rat sequence, partial and full-length cDNA and genomic clones of human SCF have been isolated. Based on the primary structure of the 164 amino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd6554c6a15818d1b63dd48d83cabff
https://doi.org/10.1016/0092-8674(90)90301-t
https://doi.org/10.1016/0092-8674(90)90301-t
Autor:
David E. Weng, Nassim Usman, T. Elise Jackson, J. Wayne Cowens, Paul Elson, Patricia A. Weiss, Ram Ganapathi, Vann P. Parker, Ernest C. Borden, Susan F. Radka, Paul Masci, Jennifer A. Lockridge, William B. Capra
Publikováno v:
Molecular cancer therapeutics. 4(6)
Purpose: This study intended to determine the maximum tolerated dose, safety, pharmacokinetic variables, clinical response, and pharmacodynamic markers of daily s.c. administration of Angiozyme. Patients and Methods: Patients with refractory solid tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9932829804380e59b82ace2c944e146b
https://pubmed.ncbi.nlm.nih.gov/15956252
https://pubmed.ncbi.nlm.nih.gov/15956252