Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Vanina Toffessi-Tcheuyap"'
Autor:
Kangsan Kim, Qinbo Zhou, Alana Christie, Christina Stevens, Yuanqing Ma, Oreoluwa Onabolu, Suneetha Chintalapati, Tiffani Mckenzie, Vanina Toffessi Tcheuyap, Layton Woolford, He Zhang, Nirmish Singla, Pravat Kumar Parida, Mauricio Marquez-Palencia, Ivan Pedrosa, Vitaly Margulis, Arthur Sagalowsky, Zhiqun Xie, Tao Wang, Steffen Durinck, Zora Modrusan, Somasekar Seshagiri, Payal Kapur, James Brugarolas, Srinivas Malladi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Tumour thrombi (TT) are intravascular extensions of renal cell carcinomas (RCC) which often lead to distant metastases. Here the authors examine the determinants of vascular invasion and metastasis in a unique cohort of RCC patients with TT using mul
Externí odkaz:
https://doaj.org/article/3266527d43244260bdb0306af8f05a4d
Autor:
Yuanqing Ma, Allison Joyce, Olivia Brandenburg, Faeze Saatchi, Christina Stevens, Vanina Toffessi Tcheuyap, Alana Christie, Quyen N. Do, Oluwatomilade Fatunde, Alyssa Macchiaroli, So C. Wong, Layton Woolford, Qurratulain Yousuf, Jeffrey Miyata, Deyssy Carrillo, Oreoluwa Onabolu, Tiffani McKenzie, Akhilesh Mishra, Tanner Hardy, Wei He, Daniel Li, Alexander Ivanishev, Qing Zhang, Ivan Pedrosa, Payal Kapur, Thomas Schluep, Steven B. Kanner, James Hamilton, James Brugarolas
Publikováno v:
Clin Cancer Res
Purpose: HIF2α is a key driver of kidney cancer. Using a belzutifan analogue (PT2399), we previously showed in tumorgrafts (TG) that ∼50% of clear cell renal cell carcinomas (ccRCC) are HIF2α dependent. However, prolonged treatment induced resist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8031fa5b1e24fe2316880d269ddff5d7
https://doi.org/10.1158/1078-0432.ccr-22-0963
https://doi.org/10.1158/1078-0432.ccr-22-0963
Autor:
James Brugarolas, James Hamilton, Steven B. Kanner, Thomas Schluep, Payal Kapur, Ivan Pedrosa, Qing Zhang, Alexander Ivanishev, Daniel Li, Wei He, Tanner Hardy, Akhilesh Mishra, Tiffani McKenzie, Oreoluwa Onabolu, Deyssy Carrillo, Jeffrey Miyata, Qurratulain Yousuf, Layton Woolford, So C. Wong, Alyssa Macchiaroli, Oluwatomilade Fatunde, Quyen N. Do, Alana Christie, Vanina Toffessi Tcheuyap, Christina Stevens, Faeze Saatchi, Olivia Brandenburg, Allison Joyce, Yuanqing Ma
Figure S5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a25177247db580f396b9946bb7f00b4
https://doi.org/10.1158/1078-0432.22489521.v1
https://doi.org/10.1158/1078-0432.22489521.v1
Autor:
James Brugarolas, James Hamilton, Steven B. Kanner, Thomas Schluep, Payal Kapur, Ivan Pedrosa, Qing Zhang, Alexander Ivanishev, Daniel Li, Wei He, Tanner Hardy, Akhilesh Mishra, Tiffani McKenzie, Oreoluwa Onabolu, Deyssy Carrillo, Jeffrey Miyata, Qurratulain Yousuf, Layton Woolford, So C. Wong, Alyssa Macchiaroli, Oluwatomilade Fatunde, Quyen N. Do, Alana Christie, Vanina Toffessi Tcheuyap, Christina Stevens, Faeze Saatchi, Olivia Brandenburg, Allison Joyce, Yuanqing Ma
Supp data legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6fd391ca71a3181f8dc7772c3d0499
https://doi.org/10.1158/1078-0432.22489509.v1
https://doi.org/10.1158/1078-0432.22489509.v1
Autor:
James Brugarolas, James Hamilton, Steven B. Kanner, Thomas Schluep, Payal Kapur, Ivan Pedrosa, Qing Zhang, Alexander Ivanishev, Daniel Li, Wei He, Tanner Hardy, Akhilesh Mishra, Tiffani McKenzie, Oreoluwa Onabolu, Deyssy Carrillo, Jeffrey Miyata, Qurratulain Yousuf, Layton Woolford, So C. Wong, Alyssa Macchiaroli, Oluwatomilade Fatunde, Quyen N. Do, Alana Christie, Vanina Toffessi Tcheuyap, Christina Stevens, Faeze Saatchi, Olivia Brandenburg, Allison Joyce, Yuanqing Ma
Purpose:HIF2α is a key driver of kidney cancer. Using a belzutifan analogue (PT2399), we previously showed in tumorgrafts (TG) that ∼50% of clear cell renal cell carcinomas (ccRCC) are HIF2α dependent. However, prolonged treatment induced resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67bbd3e8329e82a770c0d6a930905ecb
https://doi.org/10.1158/1078-0432.c.6532971.v1
https://doi.org/10.1158/1078-0432.c.6532971.v1
Autor:
James Brugarolas, James Hamilton, Steven B. Kanner, Thomas Schluep, Payal Kapur, Ivan Pedrosa, Qing Zhang, Alexander Ivanishev, Daniel Li, Wei He, Tanner Hardy, Akhilesh Mishra, Tiffani McKenzie, Oreoluwa Onabolu, Deyssy Carrillo, Jeffrey Miyata, Qurratulain Yousuf, Layton Woolford, So C. Wong, Alyssa Macchiaroli, Oluwatomilade Fatunde, Quyen N. Do, Alana Christie, Vanina Toffessi Tcheuyap, Christina Stevens, Faeze Saatchi, Olivia Brandenburg, Allison Joyce, Yuanqing Ma
Table S2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6f34309d1a7331d552d495929eeeceb
https://doi.org/10.1158/1078-0432.22489503.v1
https://doi.org/10.1158/1078-0432.22489503.v1
Autor:
Jin Zhou, Jeremy M. Simon, Chengheng Liao, Cheng Zhang, Lianxin Hu, Giada Zurlo, Xijuan Liu, Cheng Fan, Austin Hepperla, Liwei Jia, Vanina Toffessi Tcheuyap, Hua Zhong, Roy Elias, Jin Ye, W. Mike Henne, Payal Kapur, Deepak Nijhawan, James Brugarolas, Qing Zhang
Publikováno v:
Molecular cell. 82(16)
Characterized by intracellular lipid droplet accumulation, clear cell renal cell carcinoma (ccRCC) is resistant to cytotoxic chemotherapy and is a lethal disease. Through an unbiased siRNA screen of 2-oxoglutarate (2-OG)-dependent enzymes, which play
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4056e6c6f707920d13eb00e5a0bee0de
https://pubmed.ncbi.nlm.nih.gov/35764091
https://pubmed.ncbi.nlm.nih.gov/35764091
Autor:
Yuanqing Ma, Christina Stevens, Olivia Brandenburg, Vanina Toffessi Tcheuyap, Quyen N. Do, Faeze Saatchi, Tanner Hardy, Oluwatomilade Fatunde, Alyssa Macchiaroli, Jeffrey Miyata, Deyssy Carrillo, Thomas Schluep, So Wong, Alana Christie, Payal Kapur, Ivan Pedrosa, James Hamilton, James Brugarolas
Publikováno v:
Cancer Research. 82:6304-6304
Hypoxia-inducible factor 2 alpha (HIF2a) is arguably the most important driver of kidney cancer. HIF2a is constitutively activated following von Hippel-Lindau (VHL) gene inactivation, the signature event of the most common type of kidney cancer, clea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::153ef694356a37be0aad0a99977b20bd
https://doi.org/10.1158/1538-7445.am2022-6304
https://doi.org/10.1158/1538-7445.am2022-6304
Autor:
Sashi Debnath, Christina Stevens, Olivia Brandenburg, Justin Sovich, Paulina Gonzalez, Qian (Janie) Qin, Sydney Haldeman, Vanina Toffessi Tcheuyap, Alana Christie, Pawan Thapa, Ning Zhou, Aditi Mulgaonkar, Guiyang Hao, Jeffrey Miyata, Deyssy Carrillo, Jeffrey Cadeddu, Payal Kapur, Jon Anderson, Ivan Pedrosa, Marianna Dakanali, Orhan Oz, Xiankai Sun, James Brugarolas
Publikováno v:
Cancer Research. 82:2478-2478
Normally induced by hypoxia, hypoxia-inducible factor 2 alpha (HIF2a) is arguably the most important driver of kidney cancer. HIF2a is constitutively activated following von Hippel-Lindau (VHL) gene inactivation, which is the signature event of the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aedc3c31d7c79bbb5a33d72d32661911
https://doi.org/10.1158/1538-7445.am2022-2478
https://doi.org/10.1158/1538-7445.am2022-2478
Autor:
Aditi Mulgaonkar, Layton Woolford, Roy Elias, Kien Nham, Bing Guan, Guiyang Hao, Christina Stevens, Vanina Toffessi Tcheuyap, Sydney Haldeman, Jeffrey Miyata, Deyssy Carrillo, Qian (Janie) Qin, Nirmish Singla, Isaac Bowman, Jeffrey Cadeddu, Vitaly Margulis, Alana Christie, Payal Kapur, Ivan Pedrosa, Marianna Dakanali, Orhan Oz, Xiankai Sun, James Brugarolas
Publikováno v:
Cancer Research. 82:1234-1234
Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy. Program death-ligand 1 (PD-L1) and its corresponding receptor (PD-1) are the target of most FDA-approved ICIs. Perhaps unsurprisingly, PD-L1 levels are predictive of response to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6066ce652bae09330e4af4e18d14e87e
https://doi.org/10.1158/1538-7445.am2022-1234
https://doi.org/10.1158/1538-7445.am2022-1234