Phosphatidylinositol 3-Kinase/AKT Pathway Inhibition by Doxazosin Promotes Glioblastoma Cells Death, Upregulation of p53 and Triggers Low Neurotoxicity.

Autor: Mariana Maier Gaelzer, Bárbara Paranhos Coelho, Alice Hoffmann de Quadros, Juliana Bender Hoppe, Silvia Resende Terra, Maria Cristina Barea Guerra, Vanina Usach, Fátima Costa Rodrigues Guma, Carlos Alberto Saraiva Gonçalves, Patrícia Setton-Avruj, Ana Maria Oliveira Battastini, Christianne Gazzana Salbego

Publikováno v: PLoS ONE, Vol 11, Iss 4, p e0154612 (2016)

Glioblastoma is the most frequent and malignant brain tumor. Treatment includes chemotherapy with temozolomide concomitant with surgical resection and/or irradiation. However, a number of cases are resistant to temozolomide, as well as the human glio

Externí odkaz: https://doaj.org/article/275a944c5a6c48ed80753d9f1adb0e6a

Metal bashing: iron deficiency and manganese overexposure impact on peripheral nerves

Autor: Michael T. Williams, Paula A. Soto, Robyn M. Amos-Kroohs, Rocío Martinez Vivot, Vanina Usach, Charles V. Vorhees, Gonzalo Piñero, Patricia Setton-Avruj

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
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Iron (Fe) deficiency (FeD) and manganese (Mn) overexposure (MnOE) may result in several neurological alterations in the nervous system. Iron deficiency produces unique neurological deficits due to its elemental role in central nervous system (CNS) de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac065dcb7d5daadbf6d07d0d20004091
https://pubmed.ncbi.nlm.nih.gov/30652531/

EGFP transgene: a useful tool to track transplanted bone marrow mononuclear cell contribution to peripheral remyelination

Autor: Paula A. Soto, Paula V. Monje, Vanina Usach, Patricia Setton-Avruj, Gonzalo Piñero

Bone marrow mononuclear cells (BMMC) constitute a heterogeneous population with potential to promote tissue regeneration. For this reason, this cell fraction has recently become a therapeutic alternative to mesenchymal stem cells, as culture is not r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a82a1a4ef586ebdfb68482b3dadf7d
https://link.springer.com/article/10.1007/s11248-018-0062-5

DMT1 as a candidate for non-transferrin-bound iron uptake in the peripheral nervous system

Autor: Patricia Setton-Avruj, Belén Goitia, Vanina Usach, Rocío Martinez Vivot

Publikováno v: BioFactors. 39:476-484

Iron, either in its chelated form or as holotransferrin (hTf), prevents the dedifferentiation of Schwann cells (SC), cells responsible for the myelination of the peripheral nervous system (PNS). This dedifferentiation is promoted by serum deprivation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd3066dcfbed68779dde28a58aa447a2
https://doi.org/10.1002/biof.1088

Isolation and Characterization of Ischemia-Derived Astrocytes (IDAs) with Ability to Transactivate Quiescent Astrocytes

Autor: Patricia Setton-Avruj, Alberto Javier Ramos, Vanina Usach, Vanesa Cadena, Gerardo Rosciszewski, Martin M. Dodes-Traian, Veronica Murta, Alejandro Villarreal, Luis Barbeito

Publikováno v: Frontiers in Cellular Neuroscience
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Frontiers in Cellular Neuroscience, Vol 10 (2016)

Reactive gliosis involving activation and proliferation of astrocytes and microglia, is a widespread but largely complex and graded glial response to brain injury. Astroglial population has a previously underestimated high heterogeneity with cells di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4d94860f2d652c7a67911d1633f7b8
http://europepmc.org/articles/PMC4888624