Výsledky vyhledávání - "Vania E. Kenanova"

Anti-carcinoembryonic Antigen Single-chain Variable Fragment Antibody Variants Bind Mouse and Human Neonatal Fc Receptor with Different Affinities That Reveal Distinct Cross-species Differences in Serum Half-life

Autor: Ingvild Sørum Leikfoss, Inger Sandlie, Derry C. Roopenian, Vania E. Kenanova, Jan Terje Andersen, Tove Olafsen, Stian Foss, Anna M. Wu

Publikováno v: The Journal of Biological Chemistry

Background: FcRn regulates the serum half-life of IgG. Results: Fc engineering of scFv-Fc affects binding to mFcRn and hFcRn differently, which reflects blood clearance in WT and transgenic mice. Conclusion: Modulating FcRn binding to scFv-Fc reveals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a236ce17c14ea384b98deeff8c6b1b
https://doi.org/10.1074/jbc.m112.355131

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Unexpected Expression Pattern for Glycosylphosphatidylinositol-anchored HDL-binding Protein 1 (GPIHBP1) in Mouse Tissues Revealed by Positron Emission Tomography Scanning

Autor: Michael M. Weinstein, Chika Nobumori, Koon-Pong Wong, Sung-Cheng Huang, Ira J. Goldberg, Tove Olafsen, Constance V. Voss, Vania E. Kenanova, André Bensadoun, Yiping Tu, Glen Young, Loren G. Fong, Anna M. Wu, Richard H. Barnes, Anne P. Beigneux, Stephen G. Young, Brandon S.J. Davies

Publikováno v: Journal of Biological Chemistry. 285:39239-39248

Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1), a GPI-anchored endothelial cell protein, binds lipoprotein lipase (LPL) and transports it into the lumen of capillaries where it hydrolyzes triglycerides in l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15864adfac1dc434f9e1e6c1ef954db
https://doi.org/10.1074/jbc.m110.171041

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Recombinant Anti-CD20 Antibody Fragments for Small-Animal PET Imaging of B-Cell Lymphomas

Autor: Felix B. Salazar, John M. Timmerman, Pat Clarke, Tove Olafsen, David J. Betting, Andrew Raubitschek, Anna M. Wu, Jonathan W. Said, Vania E. Kenanova

Publikováno v: Journal of Nuclear Medicine. 50:1500-1508

The CD20 cell surface antigen is expressed at high levels by over 90% of B-cell non-Hodgkin lymphomas (NHL) and is the target of the anti-CD20 monoclonal antibody rituximab. To provide more sensitive, tumor-specific PET imaging of NHL, we sought to d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13b85830573b6cc4af3e41c5157c8fc3
https://doi.org/10.2967/jnumed.108.060426

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Ligand binding and antigenic properties of a human neonatal Fc receptor with mutation of two unpaired cysteine residues

Autor: Sune Justesen, Muluneh Bekele Daba, Burkhard Fleckenstein, Inger Sandlie, Gøril Berntzen, Terje E. Michaelsen, Vigdis Lauvrak, Jan Terje Andersen, Søren Buus, Vania E. Kenanova

Publikováno v: FEBS Journal. 275:4097-4110

The neonatal Fc receptor (FcRn) is a major histocompatibility complex class I-related molecule that regulates the half-life of IgG and albumin. In addition, FcRn directs the transport of IgG across both mucosal epithelium and placenta and also enhanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c35081359050bae22dea05f050209e1
https://doi.org/10.1111/j.1742-4658.2008.06551.x

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A two-tiered physiologically based model for dually labeled single-chain Fv-Fc antibody fragments

Autor: Anna M. Wu, Gregory Z. Ferl, Vania E. Kenanova, Joseph J. DiStefano

Publikováno v: Molecular Cancer Therapeutics. 5:1550-1558

Monoclonal antibodies (mAb) are being used at an increasing rate in the treatment of cancer, with current efforts focused on developing engineered antibodies that exhibit optimal biodistribution profiles for imaging and/or radioimmunotherapy. We rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f095d47d9f241ad95f6bee1a8e36bf31
https://doi.org/10.1158/1535-7163.mct-06-0072

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Optimizing Radiolabeled Engineered Anti-p185HER2 Antibody Fragments forIn vivoImaging

Autor: Vania E. Kenanova, John E. Shively, Jeffrey Y.C. Wong, Paul J. Yazaki, Desiree Crow, Sanjiv S. Gambhir, Anna M. Wu, Andrew Raubitschek, Gobalakrishnan Sundaresan, Michael F. Press, Tove Olafsen, Anne-Line Anderson, Lin Li, Lawrence E. Williams

Publikováno v: Cancer Research. 65:5907-5916

We have recently described the in vivo properties of an iodinated anti-p185HER2 engineered antibody fragment [minibody (scFv-CH3)2; 80 kDa], made from the internalizing 10H8 monoclonal antibody. Although the 10H8 minibody showed excellent binding to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb0cc6c5a8bbd01e270d1d563321b84
https://doi.org/10.1158/0008-5472.can-04-4472

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Numerical comparison of iodine-based and indium-based antibody biodistributions

Autor: Lawrence E. Williams, Tove Olafsen, Vania E. Kenanova, Anna M. Wu, Paul J. Yazaki

Publikováno v: Cancer biotherapyradiopharmaceuticals. 29(3)

Single-step iodination is often performed in preference to use of a radiometal label for initial animal biodistributions. Yet loss of iodine occurs in vivo so that it is important to measure uptake (%ID/g) differences between radiolabels.Murine biodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b376bdef8dca62a4e55b6b6a9c0cc7c0
https://pubmed.ncbi.nlm.nih.gov/24443889

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Targeting CEA in Pancreas Cancer Xenografts with a Mutated scFv-Fc Antibody Fragment

Autor: Katelyn E. McCabe, Tove Olafsen, Mark D. Girgis, Vania E. Kenanova, Anna M. Wu, James S. Tomlinson

Publikováno v: EJNMMI research, vol 1, iss 1
EJNMMI Research

Background Sensitive antibody-based tumor targeting has the potential not only to image metastatic and micrometastatic disease, but also to be the basis of targeted therapy. The vast majority of pancreas cancers express carcinoembryonic antigen (CEA)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::218bede261bc38d1ec2e04c43e7120b4
https://escholarship.org/uc/item/0jf795t6

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Anti-CA19-9 diabody as a PET imaging probe for pancreas cancer

Autor: Anna M. Wu, Katelyn E. McCabe, Tove Olafsen, Vania E. Kenanova, Mark D. Girgis, James S. Tomlinson

Publikováno v: The Journal of surgical research. 170(2)

Background Intact antibodies are poor imaging agents due to a long serum half-life (10–20 d) preventing adequate contrast between the tumor and surrounding blood. Smaller engineered antibody fragments overcome this problem by exhibiting shorter ser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4377931da6640c7f93a7de4acffdf78
https://pubmed.ncbi.nlm.nih.gov/21601881

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