SIN-3 functions through multi-protein interaction to regulate apoptosis, autophagy, and longevity in Caenorhabditis elegans

Autor: Chandrika Konwar, Jayant Maini, Surbhi Kohli, Vani Brahmachari, Daman Saluja

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)

Abstract SIN3/HDAC is a multi-protein complex that acts as a regulatory unit and functions as a co-repressor/co-activator and a general transcription factor. SIN3 acts as a scaffold in the complex, binding directly to HDAC1/2 and other proteins and p

Externí odkaz: https://doaj.org/article/7371c716cd074e05bab6b9c8bb0fcc60

Correlation of drug resistance with single nucleotide variations through genome analysis and experimental validation in a multi-drug resistant clinical isolate of M. tuberculosis

Autor: Kausik Bhattacharyya, Vishal Nemaysh, Monika Joon, Ramendra Pratap, Mandira Varma-Basil, Mridula Bose, Vani Brahmachari

Publikováno v: BMC Microbiology, Vol 20, Iss 1, Pp 1-14 (2020)

Abstract Background Genome sequencing and genetic polymorphism analysis of clinical isolates of M. tuberculosis is carried out to gain further insight into molecular pathogenesis and host-pathogen interaction. Therefore the functional evaluation of t

Externí odkaz: https://doaj.org/article/3a565b38d8ac40ac9b323fd65e45d81d

Interaction of the Chromatin Remodeling Protein hINO80 with DNA.

Autor: Shweta Mendiratta, Shipra Bhatia, Shruti Jain, Taniya Kaur, Vani Brahmachari

Publikováno v: PLoS ONE, Vol 11, Iss 7, p e0159370 (2016)

The presence of a highly conserved DNA binding domain in INO80 subfamily predicted that INO80 directly interacts with DNA and we demonstrated its DNA binding activity in vitro. Here we report the consensus motif recognized by the DBINO domain identif

Externí odkaz: https://doaj.org/article/ac5e980346b4422fb9927bc1fba1c801

Identification and Validation of a Putative Polycomb Responsive Element in the Human Genome.

Autor: Hemant Bengani, Shweta Mendiratta, Jayant Maini, Dasari Vasanthi, Hina Sultana, Mohsen Ghasemi, Jasmine Ahluwalia, Sowmya Ramachandran, Rakesh K Mishra, Vani Brahmachari

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e67217 (2013)

Epigenetic cellular memory mechanisms that involve polycomb and trithorax group of proteins are well conserved across metazoans. The cis-acting elements interacting with these proteins, however, are poorly understood in mammals. In a directed search

Externí odkaz: https://doaj.org/article/2b0abeb79d68463991ae82376b8581e0

Comparison of Immunocytochemistry and Immunohistochemistry on Breast Carcinoma: A Boon or a Bane?

Autor: Geethamala K; Department of Pathology, Belagavi Institute of Medical Sciences, Belagavi, Karnataka, India., Murthy VS; Department of Pathology, ESIC Medical College and PGIMSR, Rajajinagar, Bengaluru, Karnataka, India., Vani BR; Department of Pathology, ESIC Medical College and PGIMSR, Rajajinagar, Bengaluru, Karnataka, India., Rao MS; Department of Pathology, ESIC Medical College and PGIMSR, Rajajinagar, Bengaluru, Karnataka, India., Thejaswini MU; Department of Pathology, ESIC Medical College and PGIMSR, Rajajinagar, Bengaluru, Karnataka, India., Padmaja KP; Department of Pathology, ESIC Medical College and PGIMSR, Rajajinagar, Bengaluru, Karnataka, India.

Publikováno v: Journal of laboratory physicians [J Lab Physicians] 2017 Jan-Mar; Vol. 9 (1), pp. 5-10.