Výsledky vyhledávání - "Vanessa Y Soto"

Akademický článek

Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life.

Autor: Kathleen E Fischer, Jonathan A L Gelfond, Vanessa Y Soto, Chul Han, Shinichi Someya, Arlan Richardson, Steven N Austad

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0126644 (2015)

Rapamycin, an mTOR inhibitor, has been shown to extend lifespan in a range of model organisms. It has been reported to extend lifespan in multiple strains of mice, administered chronically or acutely early or late in life. The ability of rapamycin to

Externí odkaz: https://doaj.org/article/42ea1c25437542dca4fdeb96acdbc959

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mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging

Autor: Jordan B. Jahrling, Veronica Galvan, Stacy A. Hussong, Kathleen E. Fischer, Ai-Ling Lin, Stephen F. Hernandez, Matthew J. Hart, Candice E. Van Skike, Vanessa Y. Soto, Raquel R. Burbank, James Cuvillier, Steven N. Austad, Jonathan J. Halloran, Martin A. Javors

Publikováno v: Aging Cell

Cerebrovascular dysfunction and cognitive decline are highly prevalent in aging, but the mechanisms underlying these impairments are unclear. Cerebral blood flow decreases with aging and is one of the earliest events in the pathogenesis of Alzheimer'

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ee55649ebf509d9122466500262854
https://doi.org/10.1111/acel.13057

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A cross-sectional study of male and female C57BL/6Nia mice suggests lifespan and healthspan are not necessarily correlated

Autor: Jonathan Gelfond, Kathleen E. Fischer, Arlan Richardson, Jessica M. Hoffman, Vanessa Y. Soto, Steven N. Austad, Lauren B. Sloane

Publikováno v: Aging (Albany NY)

Lifespan provides a discrete metric that is intuitively appealing and the assumption has been that healthspan is extended concomitant with lifespan. Medicine has been more successful at extending life than preserving health during aging. Intervention

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb28886a929404bb399100ce75fc9825
https://doi.org/10.18632/aging.101059

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Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice

Autor: Michael Kinter, Daniel Pulliam, Arlan Richardson, Kaitlyn Riddle, Wilson C. Fok, Gavin Pharaoh, Holly Van Remmen, Vanessa Y. Soto, Shauna Hill, Jonathan D. Wren, Sathyaseelan S. Deepa, Vivian Diaz, Carlo Viscomi, Constantin Georgescu, Kathleen E. Fischer

Publikováno v: Aging Cell

Summary Loss of SURF1, a Complex IV assembly protein, was reported to increase lifespan in mice despite dramatically lower cytochrome oxidase (COX) activity. Consistent with this, our previous studies found advantageous changes in metabolism (reduced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::866d1966da85be4d1e958eb572e6f219
http://hdl.handle.net/11577/3321362

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Sco2 deficient mice develop increased adiposity and insulin resistance

Autor: Yuhong Liu, Holly Van Remmen, Shauna Hill, Pavithra Premkumar, Sathyaseelan S. Deepa, Vanessa Y. Soto, Kavithalakshmi Sataranatarajan, Daniel Pulliam, Kathleen E. Fischer

Publikováno v: Molecular and cellular endocrinology. 455

Cytochrome c oxidase (COX) is an essential transmembrane protein complex (Complex IV) in the mitochondrial respiratory electron chain. Mutations in genes responsible for the assembly of COX are associated with Leigh syndrome, cardiomyopathy, spinal m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec48616ffaf42fb9447b0ed39ec1405b
https://pubmed.ncbi.nlm.nih.gov/28428045

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Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life

Autor: Jonathan Gelfond, Steven N. Austad, Shinichi Someya, Vanessa Y. Soto, Arlan Richardson, Chul Han, Kathleen E. Fischer

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0126644 (2015)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9e1c500a8f82305847e6ffa90227f1
http://europepmc.org/articles/PMC4433347?pdf=render

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Obesity-induced oxidative stress, accelerated functional decline with age and increased mortality in mice

Autor: Kathleen E. Fischer, Danuta Sosnowska, Vanessa Y. Soto, Adam B. Salmon, Arlan Richardson, Yiqiang Zhang, Yuhong Liu

Publikováno v: Archives of biochemistry and biophysics. 576

Obesity is a serious chronic disease that increases the risk of numerous co-morbidities including metabolic syndrome, cardiovascular disease and cancer as well as increases risk of mortality, leading some to suggest this condition represents accelera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ab068a1d4d23721491b6551a3e98b1
https://pubmed.ncbi.nlm.nih.gov/25558793

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Rapamycin Extends Life and Health in C57BL/6 Mice

Autor: Samantha Rendon, Kathleen E. Fischer, Yuji Ikeno, Stephen Treaster, Jonathan Gelfond, Arlan Richardson, Yiqiang Zhang, Holly Van Remmen, Keith Maslin, Gene B. Hubbard, Martin A. Javors, Steven N. Austad, Vivian Diaz, Walter F. Ward, Alex Bokov, Vanessa Y. Soto, Lauren B. Sloane

Target of rapamycin inhibition by rapamycin feeding has previously been shown to extend life in genetically heterogeneous mice. To examine whether it similarly affected mouse health, we fed encapsulated rapamycin or a control diet to C57BL/6Nia mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c4629069d4c8e1d5221e1092816c20
https://europepmc.org/articles/PMC4038246/

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