Budget Impact Analysis of Adopting a One-Step Nucleic Acid Amplification Testing (NAAT) Alone Diagnostic Pathway for Clostridioides difficile in Japan Compared to a Two-Step Algorithm with Glutamate Dehydrogenase/Toxin Followed by NAAT

Autor: Vanessa W. Lim, Takeshi Tomaru, Brandon Chua, Yan Ma, Katsunori Yanagihara

Publikováno v: Diagnostics, Vol 13, Iss 8, p 1463 (2023)

Clostridioides difficile infection (CDI) is a major healthcare-associated infection that leads to a significant health economic burden in Japan. Using a decision tree model, we evaluated the budget impact of adopting a one-step nucleic acid amplifica

Externí odkaz: https://doaj.org/article/a1e090f9dc7f4bb28e3d04d298122272

Competitive ELISA for a serologic test to detect dengue serotype-specific anti-NS1 IgGs using high-affinity UB-DNA aptamers

Autor: Ichiro Hirao, Yee Sin Leo, Ken-ichiro Matsunaga, Shawn Vasoo, Tun-Linn Thein, William Sun, Vanessa W. Lim, Michiko Kimoto

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)

Serologic tests to detect specific IgGs to antigens related to viral infections are urgently needed for diagnostics and therapeutics. We present a diagnostic method for serotype-specific IgG identification of dengue infection by a competitive enzyme-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a4e40defc86dd705896c62835a11b79
http://europepmc.org/articles/PMC8429655

Immune cell phenotypes associated with disease severity and long-term neutralizing antibody titers after natural dengue virus infection

Autor: Danilo R. Casimiro, Tsin W. Yeo, Menaka Priyadharsani Rajapakse, Vanessa W. Lim, Bernett Lee, Laura Rivino, Amit Singhal, Bing Lim, Tun-Linn Thein, Thomas Loy, Melissa Hui Yen Chng, Durgalakshmi Sathiakumar, Kalpit A. Vora, Katja Fink, Lisa Tucker-Kellogg, Ying Xiu Toh, Angeline Rouers, Kaval Kaur, Yee Sin Leo, Evan W. Newell

Publikováno v: Cell Reports Medicine
Cell Reports Medicine, Vol 2, Iss 5, Pp 100278-(2021)

Summary Prior immunological exposure to dengue virus can be both protective and disease-enhancing during subsequent infections with different dengue virus serotypes. We provide here a systematic, longitudinal analysis of B cell, T cell, and antibody

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43899449689d0e372238d91afde41189
http://europepmc.org/articles/PMC8149372

Novel differential linear B-cell epitopes to identify Zika and dengue virus infections in patients

Autor: François Nosten, Vanessa W. Lim, Yiu-Wing Kam, Jing Tan, Fok-Moon Lum, Farhana Abu Bakar, Wanitda Watthanaworawit, Lisa F. P. Ng, Siti Naqiah Amrun, Wearn-Xin Yee, Clare Ling, Yee Sin Leo, Bernett Lee, Laurent Rénia

Publikováno v: Clinical & Translational Immunology, Vol 8, Iss 7, Pp n/a-n/a (2019)
Clinical & Translational Immunology, Vol 9, Iss 2, Pp n/a-n/a (2020)
Clinical & Translational Immunology
CLINICAL & TRANSLATIONAL IMMUNOLOGY

BackgroundRecent Zika virus (ZIKV) outbreaks challenged existing laboratory diagnostic standards, especially for serology-based methods. Due to the genetic and structural similarity of ZIKV with other flaviviruses, this results in cross-reactive anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bce7ce53f7f9fe9952cae823b609f76
https://doi.org/10.1002/cti2.1066

Passive immune therapy and other immunomodulatory agents for the treatment of severe influenza: Systematic review and meta-analysis

Autor: Vanessa W. Lim, Mark I-Cheng Chen, Barnaby Edward Young, Lorainne Tudor Car, Yee Sin Leo

Publikováno v: Influenza and Other Respiratory Viruses

Background: A range of immunomodulatory therapies have been proposed as adjuncts to conventional antivirals to suppress harmful inflammation during severe influenza infection. We conducted a systematic review to assess available data of the effect of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f66d4ad010ac32237e8f1467620c0af
https://pubmed.ncbi.nlm.nih.gov/31733048