Novel signalling pathways in nephrogenic syndrome of inappropriate antidiuresis: functional implication of site‐specific AQP2 phosphorylation

Autor: Maria Venneri, Vanessa Vezzi, Annarita Di Mise, Marianna Ranieri, Mariangela Centrone, Grazia Tamma, Lene N. Nejsum, Giovanna Valenti

Publikováno v: Venneri, M, Vezzi, V, Mise, A D, Ranieri, M, Centrone, M, Tamma, G, Nejsum, L N & Valenti, G 2023, ' Novel signaling pathways in Nephrogenic Syndrome of Inappropriate Antidiuresis : Functional implication of site-specific AQP2 phosphorylation ', The Journal of Physiology . https://doi.org/10.1113/JP284039

Nephrogenic Syndrome of Inappropriate Antidiuresis (NSIAD) is a rare X-linked disease caused by gain-of-function mutations of the V2 vasopressin receptor (V2R). NSIAD patients are characterized by the inability to excrete a free water load and inappr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b3526ec63434d82a77914470344e653
https://doi.org/10.1113/jp284039

Intermittent β-adrenergic blockade downregulates the gene expression of β-myosin heavy chain in the mouse heart

Autor: Roberto Rizzi, Liviana Catalano, Caterina Ambrosio, Sonia Maccari, Tonino Stati, Paola Molinari, Vanessa Vezzi, Federica Barbagallo, Valentina Pace, Paola Matarrese, Giuseppe Marano, Mario Patrizio, Maria Cristina Grò

Publikováno v: European journal of pharmacology. 882

Expression of the β-myosin heavy chain (β-MHC), a major component of the cardiac contractile apparatus, is tightly regulated as even modest increases can be detrimental to heart under stress. In healthy hearts, continuous inhibition of β-adrenergi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64be38146ed5239bb90b7be8b61a524
https://pubmed.ncbi.nlm.nih.gov/32585157

β-blockers Reverse Agonist-Induced β

Autor: Sonia, Maccari, Vanessa, Vezzi, Federica, Barbagallo, Tonino, Stati, Barbara, Ascione, Maria Cristina, Grò, Liviana, Catalano, Giuseppe, Marano, Paola, Matarrese, Caterina, Ambrosio, Paola, Molinari

Publikováno v: International Journal of Molecular Sciences

Altered β-adrenergic receptor (β-AR) density has been reported in cells, animals, and humans receiving β-blocker treatment. In some cases, β-AR density is upregulated, but in others, it is unaffected or even reduced. Collectively, these results w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b1746c8bc939186ff7e6a8c004606f96
https://pubmed.ncbi.nlm.nih.gov/31947522

Systematic errors in detecting biased agonism: Analysis of current methods and development of a new model-free approach

Autor: H. Ongun Onaran, Vanessa Vezzi, Erzsebet Madaras Koncz, Maria Cristina Grò, Caterina Ambrosio, Sudarshan Rajagopal, Tommaso Costa, Özlem Uğur

Publikováno v: Scientific Reports

Discovering biased agonists requires a method that can reliably distinguish the bias in signalling due to unbalanced activation of diverse transduction proteins from that of differential amplification inherent to the system being studied, which invar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3655c5d315044653016c902f18143cdf

Characterisation of the novel mixed Mu-NOP peptide ligand dermorphin-N/OFQ (DeNo)

Autor: Mark F. Bird, Girolamo Calo, David G. Lambert, Maria Camilla Cerlesi, Paola Molinari, Davide Malfacini, Remo Guerrini, Vanessa Vezzi, Mark Brown, Lorenzo Di Cesare Mannelli, Laura Micheli, Carla Ghelardini

Publikováno v: PLoS ONE, Vol 11, Iss 6, p e0156897 (2016)
PLoS ONE

Introduction Opioid receptors are currently classified as Mu (μ), Delta (δ), Kappa (κ) plus the opioid related nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP). Despite compelling evidence for interactions and benefits of targeting more than

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::541c2fe059524c9ba6f7821311cb1c7e
http://hdl.handle.net/11392/2347044