Výsledky vyhledávání - "Vanessa Tolotto"

Akademický článek

Transcription of endogenous retroviruses in senescent cells contributes to the accumulation of double-stranded RNAs that trigger an anti-viral response that reinforces senescence

Autor: Eros Di Giorgio, Liliana Ranzino, Vanessa Tolotto, Emiliano Dalla, Matteo Burelli, Nicolò Gualandi, Claudio Brancolini

Publikováno v: Cell Death and Disease, Vol 15, Iss 2, Pp 1-15 (2024)

Abstract An important epigenetic switch marks the onset and maintenance of senescence. This allows transcription of the genetic programs that arrest the cell cycle and alter the microenvironment. Transcription of endogenous retroviruses (ERVs) is als

Externí odkaz: https://doaj.org/article/c24b20f0212c4f1da4751cf55b74e3aa

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Abstract B014: The role of HDAC-MEF2 axis in the epigenetic control of immune tumoral microenvironment

Autor: Martina Minisini, Emiliano Dalla, Vanessa Tolotto, Claudio Brancolini

Publikováno v: Cancer Research. 82:B014-B014

Epigenetic mechanisms have a main impact on cancer regulation and on microenvironment control. In the context of leiomyosarcoma (LMS), a highly aggressive and immunologically cold cancer, class IIa histone deacetylases (HDACs) and myocyte enhancer fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53f4860a187cb17e629ffaee2479aca7
https://doi.org/10.1158/1538-7445.cancepi22-b014

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A regulative epigenetic circuit supervised by HDAC7 represses IGFBP6 and IGFBP7 expression to sustain mammary stemness

Autor: Eros Di Giorgio, Vanessa Tolotto, Claudio Brancolini, Valentina Cutano, Martina Minisini, Emiliano Dalla

Background: In the breast, the pleiotropic epigenetic regulator HDAC7 can influence stemness. Materials & Methods: The authors used MCF10 cells knocked-out for HDAC7 to explore the contribution of HDAC7 to IGF1 signaling. Results: HDAC7 buffers H3K27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f18c637513919c42b31379f005cbbd5
http://hdl.handle.net/11390/1207522

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Mitochondrial Oxidative Stress Induces Rapid Intermembrane Space/Matrix Translocation of Apurinic/Apyrimidinic Endonuclease 1 Protein through TIM23 Complex

Autor: Michał Wasilewski, Vanessa Tolotto, Praveenraj Elancheliyan, Veronica Bazzani, Arianna Barchiesi, Agnieszka Chacinska, Carlo Vascotto

Publikováno v: Journal of molecular biology. 432(24)

Mitochondria are essential cellular organelles that import the majority of proteins to sustain their function in cellular metabolism and homeostasis. Due to their role in oxidative phosphorylation, mitochondria are constantly affected by oxidative st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42016d7ed0ed2621ed5fd8db607d165f
https://pubmed.ncbi.nlm.nih.gov/33197464

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