The role of structuralvscellular remodeling in arrhythmogenesis: personalized computer models of atrial fibrillation

Autor: Andrey V. Pikunov, Roman A. Syunyaev, Rheeda Ali, Adityo Prakosa, Patrick M. Boyle, Vanessa Steckmeister, Ingo Kutschka, Eric Rytkin, Niels Voigt, Natalia Trayanova, Igor R. Efimov

Atrial fibrillation (AF) is a progressive disease involving both structural and functional remodeling. To investigate the contribution of cell-scale functional remodeling to AF pathogenesis, we combined personalized 3D anatomical models with patholog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c797acfc0169d53fb283a846c73319c
https://doi.org/10.1101/2023.05.13.540632

Altered atrial cytosolic calcium handling contributes to the development of postoperative atrial fibrillation

Autor: Constanze Schmidt, Funsho E Fakuade, Aschraf El-Essawi, Fleur E. Mason, George Kensah, Julius Ryan D. Pronto, Charles M. Pearman, Hassina Baraki, Bernhard C. Danner, Fereshteh Haghighi, Stefanie Kestel, Ingo Kutschka, Karim Taha, Arco J. Teske, Vanessa Steckmeister, Judith Gronwald, Julia Menzel, Niels Voigt, Katharine M. Dibb, F. Seibertz, Felix Wiedmann, Blanche Schwappach

Publikováno v: Fakuade, F E, Steckmeister, V, Seibertz, F, Gronwald, J, Kestel, S, Menzel, J, Pronto, J R D, Taha, K, Haghighi, F, Kensah, G, Pearman, C M, Wiedmann, F, Teske, A J, Schmidt, C, Dibb, K M, El-Essawi, A, Danner, B C, Baraki, H, Schwappach, B, Kutschka, I, Mason, F E & Voigt, N 2020, ' Altered Atrial Cytosolic Calcium Handling Contributes to the Development of Postoperative Atrial Fibrillation ', Cardiovascular research . https://doi.org/10.1093/cvr/cvaa162

AIMS: Atrial fibrillation is a commonly occurring arrhythmia after cardiac surgery (postoperative AF, poAF) and is associated with poorer outcomes. Considering that reduced atrial contractile function is a predictor of poAF and that Ca2+ plays an imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e66d1a42ba9e37828433165a4199b35
https://doi.org/10.1093/cvr/cvaa162

Personalization of Mathematical Models of Human Atrial Action Potential

Autor: Andrey Pikunov, R. A. Syunyaev, Igor R. Efimov, Vanessa Steckmeister, Niels Voigt, Ingo Kutschka

Publikováno v: Smart Modelling For Engineering Systems ISBN: 9789813347083

Atrial cardiomyocytes demonstrate a wide spectrum of patient-specific, tissue-specific, and pathology-specific Action potential (AP) phenotypes due to differences in protein expression and posttranslational modifications. Accurate simulation of the A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::695222596175b1d3a30da15b8568bc84
https://doi.org/10.1007/978-981-33-4709-0_19