Výsledky vyhledávání - "Vanessa Ottenhaus"

MitsunobuAlkylation of Cancerostatic 5-Fluorouridine with (2E)-10-Hydroxydec-2-enoic Acid, a Fatty Acid from Royal Jelly with Multiple Biological Activities

Autor: Vanessa Ottenhaus, Helmut Rosemeyer

Publikováno v: Chemistry & Biodiversity. 12:1307-1312

5-Fluorouridine (1) - a nucleoside antimetabolite with strong cancerostatic properties - was protected i) at the 2'- and 3'-OH groups with a heptan-4-ylidene residue and ii) at the 5'-OH group with a (4-methoxyphenyl)(diphenyl)methyl residue. This fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5d66e44aa39a9f5a866616a43d14db
https://doi.org/10.1002/cbdv.201500048

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Nucleolipids of the cancerostatic 5-fluorouridine: synthesis, adherence to oligonucleotides, and incorporation in artificial lipid bilayers

Autor: Helmut Rosemeyer, Emma Werz, Malayko Montilla Martinez, Edith Malecki, Christine Knies, Vanessa Ottenhaus

Publikováno v: Chemistrybiodiversity. 11(2)

5-Fluorouridine (1a) was converted to its N(3)-farnesylated nucleoterpene derivative 8 by direct alkylation with farnesyl bromide (4). Reaction of the cancerostatic 1a with either acetone, heptan-4-one, nonadecan-10-one, or hentriacontan-16-one affor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d18e7a8fa0cf923f8cca2b72020a81
https://pubmed.ncbi.nlm.nih.gov/24591313

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