Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Vanessa O. Zambelli"'
A human TRPV1 genetic variant within the channel gating domain regulates pain sensitivity in rodents
Autor:
Shufang He, Vanessa O. Zambelli, Pritam Sinharoy, Laura Brabenec, Yang Bian, Freeborn Rwere, Rafaela C.R. Hell, Beatriz Stein Neto, Barbara Hung, Xuan Yu, Meng Zhao, Zhaofei Luo, Chao Wu, Lijun Xu, Katrin J. Svensson, Stacy L. McAllister, Creed M. Stary, Nana-Maria Wagner, Ye Zhang, Eric R. Gross
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 3 (2023)
Pain signals are relayed to the brain via a nociceptive system, and in rare cases, this nociceptive system contains genetic variants that can limit the pain response. Here, we questioned whether a human transient receptor potential vanilloid 1 (TRPV1
Externí odkaz:
https://doaj.org/article/37d0f51fb16d49a8b7cc88f9c3a78b93
Autor:
Rafaela Indalecio Moreno, Vanessa O. Zambelli, Gisele Picolo, Yara Cury, André C. Morandini, Antonio Carlos Marques, Juliana Mozer Sciani
Publikováno v:
Marine Drugs, Vol 20, Iss 10, p 614 (2022)
Neuroinflammation is a condition associated with several types of dementia, such as Alzheimer’s disease (AD), mainly caused by an inflammatory response to amyloid peptides that induce microglial activation, with subsequent cytokine release. Neurona
Externí odkaz:
https://doaj.org/article/b01c7a38d7374700adee6320ea154810
Autor:
Morena Brazil Sant'Anna, Aline C. Giardini, Marcio A. C. Ribeiro, Flavia S. R. Lopes, Nathalia B. Teixeira, Louise F. Kimura, Michelle C. Bufalo, Orlando G. Ribeiro, Andrea Borrego, Wafa H. K. Cabrera, Julio C. B. Ferreira, Vanessa O. Zambelli, Osvaldo A. Sant'Anna, Gisele Picolo
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Crotoxin (CTX), the main neurotoxin from Crotalus durissus terrificus snake venom, has anti-inflammatory, immunomodulatory and antinociceptive activities. However, the CTX-induced toxicity may compromise its use. Under this scenario, the use of nanop
Externí odkaz:
https://doaj.org/article/91b038fcbb5240028881d391d04c7285
Autor:
Bárbara G. de Freitas, Natália G. Hösch, Leandro M. Pereira, Tereza C. Barbosa, Gisele Picolo, Yara Cury, Vanessa O. Zambelli
Publikováno v:
Toxins, Vol 13, Iss 12, p 912 (2021)
Crotalphine (CRP) is a structural analogue to a peptide that was first identified in the crude venom from the South American rattlesnake Crotalus durissus terrificus. This peptide induces a potent and long-lasting antinociceptive effect that is media
Externí odkaz:
https://doaj.org/article/39147efa9e734fd8a11632fe939d13a2
Autor:
Bárbara B. Martins, Natália G. Hösch, Queren A. Alcantara, Grant R. Budas, Che-Hong Chen, Daria Mochly-Rosen, Julio C. B. Ferreira, Vanessa O. Zambelli
Publikováno v:
Biomolecules, Vol 11, Iss 12, p 1798 (2021)
Protein kinase Cε (PKCε) is highly expressed in nociceptor neurons and its activation has been reported as pro-nociceptive. Intriguingly, we previously demonstrated that activation of the mitochondrial PKCε substrate aldehyde dehydrogenase-2 (ALDH
Externí odkaz:
https://doaj.org/article/5213b128278f4f5fbdb2e18abf2c5292
Autor:
Aline C. Giardini, Bianca G. Evangelista, Morena B. Sant’Anna, Barbara B. Martins, Carmen L. P. Lancellotti, Adriano P. Ciena, Marucia Chacur, Rosana L. Pagano, Orlando G. Ribeiro, Vanessa O. Zambelli, Gisele Picolo
Publikováno v:
Toxins, Vol 13, Iss 11, p 827 (2021)
Multiple sclerosis (MS) is a demyelinating disease of inflammatory and autoimmune origin, which induces sensory and progressive motor impairments, including pain. Cells of the immune system actively participate in the pathogenesis and progression of
Externí odkaz:
https://doaj.org/article/f282483231014517b60503237b3b4e99
Autor:
Bárbara Guimaraes de Freitas, Leandro Márcio Pereira, Flávia Vianna Santa-Cecília, Natália Gabriele Hösch, Gisele Picolo, Yara Cury, Vanessa O. Zambelli
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
The use of morphine, the standard opioid drug, is limited by its undesirable effects, such as tolerance, physical dependence, and hyperalgesia (increased pain sensitivity). Clinical and preclinical studies have reported development of hyperalgesia af
Externí odkaz:
https://doaj.org/article/8e069eaedc924aefbb03eaea8a931b26
Autor:
Fabiana B. Benatti, Cíntia N. H. Miyake, Wagner S. Dantas, Vanessa O. Zambelli, Samuel K. Shinjo, Rosa M. R. Pereira, Maria Elizabeth R. Silva, Ana Lúcia Sá-Pinto, Eduardo Borba, Eloisa Bonfá, Bruno Gualano
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Systemic lupus erythematosus (SLE) patients may show increased insulin resistance (IR) when compared with their healthy peers. Exercise training has been shown to improve insulin sensitivity in other insulin-resistant populations, but it has never be
Externí odkaz:
https://doaj.org/article/52bae73e853441c0bbd7a84e40fa6e3c
Publikováno v:
Toxins, Vol 9, Iss 12, p 406 (2017)
Animal venoms comprise a complex mixture of components that affect several biological systems. Based on the high selectivity for their molecular targets, these components are also a rich source of potential therapeutic agents. Among the main componen
Externí odkaz:
https://doaj.org/article/a8bcb0354cdc4ee5b208fd14eab6872f
A human TRPV1 genetic variant within the channel gating domain regulates pain sensitivity in rodents
Autor:
Shufang He, Vanessa O. Zambelli, Pritam Sinharoy, Laura Brabenec, Yang Bian, Freeborn Rwere, Rafaela C.R. Hell, Beatriz Stein Neto, Barbara Hung, Xuan Yu, Meng Zhao, Zhaofei Luo, Chao Wu, Lijun Xu, Katrin J. Svensson, Stacy L. McAllister, Creed M. Stary, Nana-Maria Wagner, Ye Zhang, Eric R. Gross
Publikováno v:
The Journal of clinical investigation.
Pain signals are relayed to the brain via a nociceptive system, and in rare situations, this nociceptive system contains genetic variants that can limit pain response. Here we questioned whether a human transient receptor potential vanilloid 1 (TRPV1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdcd3d615c375cab19e4dfbe0dc15610
https://pubmed.ncbi.nlm.nih.gov/36472910
https://pubmed.ncbi.nlm.nih.gov/36472910