Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Vanessa M. Knab"'
Autor:
Sabrina Tripolt, Heidi A. Neubauer, Vanessa M. Knab, Dominik P. Elmer, Fritz Aberger, Richard Moriggl, Daniela A. Fux
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 2, Pp 270-279 (2021)
The opioid crisis of pain medication bears risks from addiction to cancer progression, but little experimental evidence exists. Expression of δ-opioid receptors (DORs) correlates with poor prognosis for breast cancer patients, but mechanistic insigh
Externí odkaz:
https://doaj.org/article/28e4e04ebc5c41fa8f9757a3499c466a
Autor:
Ingeborg Menzl, Tinghu Zhang, Angelika Berger-Becvar, Reinhard Grausenburger, Gerwin Heller, Michaela Prchal-Murphy, Leo Edlinger, Vanessa M. Knab, Iris Z. Uras, Eva Grundschober, Karin Bauer, Mareike Roth, Anna Skucha, Yao Liu, John M. Hatcher, Yanke Liang, Nicholas P. Kwiatkowski, Daniela Fux, Andrea Hoelbl-Kovacic, Stefan Kubicek, Junia V. Melo, Peter Valent, Thomas Weichhart, Florian Grebien, Johannes Zuber, Nathanael S. Gray, Veronika Sexl
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Cyclin-dependent kinases are deregulated in blood cancers. Here, the authors show that CDK8, independent of its kinase activity, regulates mTOR signalling for the maintenance of BCR-ABL1+ leukemia, and that the dual inhibition of CDK8 and mTOR signal
Externí odkaz:
https://doaj.org/article/90ab601100a74a6da15edcbbea0a9c4e
Autor:
Eva Maria Putz, Julia List, Vanessa M. Knab, Klara Klein, Daniela Prinz, Bojan Polić, Veronika Sexl, Gerwin Heller, Nicoletta Leidenfrost, Agnieszka Witalisz-Siepracka, Ingeborg Menzl, Dagmar Gotthardt
Publikováno v:
European Journal of Immunology
Volume 50
Issue 6
Volume 50
Issue 6
NK cells are innate lymphocytes responsible for lysis of pathogen‐infected and transformed cells. One of the major activating receptors required for target cell recognition is the NK group 2D (NKG2D) receptor. Numerous reports show the necessity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::102914f25a0a550daa6828b4c62f1df6
http://europepmc.org/articles/PMC7318224
http://europepmc.org/articles/PMC7318224
Autor:
Belinda S, Schmalzbauer, Teresemary, Thondanpallil, Gerwin, Heller, Alessia, Schirripa, Clio-Melina, Sperl, Isabella M, Mayer, Vanessa M, Knab, Sofie, Nebenfuehr, Markus, Zojer, André C, Mueller, Frédéric, Fontaine, Thorsten, Klampfl, Veronika, Sexl, Karoline, Kollmann
Publikováno v:
Cancers. 14(6)
Cyclin-dependent kinase 6 (CDK6) represents a novel therapeutic target for the treatment of certain subtypes of acute myeloid leukaemia (AML). CDK4/6 kinase inhibitors have been widely studied in many cancer types and their effects may be limited by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ebecb1483b53b7f57229c41bd0f3eb22
https://pubmed.ncbi.nlm.nih.gov/35326705
https://pubmed.ncbi.nlm.nih.gov/35326705
Autor:
Yanke Liang, Junia V. Melo, Karin Bauer, Ingeborg Menzl, Nicholas Kwiatkowski, Johannes Zuber, Vanessa M. Knab, Veronika Sexl, Michaela Prchal-Murphy, Tinghu Zhang, Stefan Kubicek, Peter Valent, Iris Z. Uras, Anna Skucha, Florian Grebien, Eva Grundschober, Gerwin Heller, Thomas Weichhart, Nathanael S. Gray, Angelika Berger-Becvar, Yao Liu, Mareike Roth, Daniela A. Fux, Andrea Hoelbl-Kovacic, Leo Edlinger, John M. Hatcher, Reinhard Grausenburger
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Cyclin-dependent kinases (CDKs) are frequently deregulated in cancer and represent promising drug targets. We provide evidence that CDK8 has a key role in B-ALL. Loss of CDK8 in leukemia mouse models significantly enhances disease latency and prevent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e2932886a8bb5546af466f37450724
http://link.springer.com/article/10.1038/s41467-019-12656-x
http://link.springer.com/article/10.1038/s41467-019-12656-x
Autor:
Vanessa M. Knab, Daniela A. Fux, Barbara Bauder, Sabrina Tripolt, Alexandra Schoos, Cordula Gabriel, Daniela A. Wagner, Angelika Url
Publikováno v:
Veterinary and Comparative Oncology. 17:507-521
Therapy of canine mammary tumours (CMTs) with classical antitumour drugs is problematic, so better therapeutic options are needed. Palbociclib (PD-0332991) is an innovative and effective anticancer drug for the treatment of breast cancer in women. Pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2546db83913a388550b363aa2ba645fb
https://doi.org/10.1111/vco.12514
https://doi.org/10.1111/vco.12514
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 370:480-489
Opioids promote tumor angiogenesis in mammary malignancies, but the underlying signaling mechanism is largely unknown. The current study investigated the hypothesis that stimulation of δ-opioid receptors (DOR) in breast cancer (BCa) cells activates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a8f78f49bd981a148e1fc29ca62aa79
https://doi.org/10.1124/jpet.119.257501
https://doi.org/10.1124/jpet.119.257501
Autor:
Olena Andrukhova, Seham M. Rabadi, Braden Corbin, Julia M. Hum, Marta Christov, Akira Maeda, Reinhold G. Erben, Vanessa M. Knab, Pu Ni, Harald Jüppner, Kenneth E. White
Publikováno v:
Endocrinology. 158:1130-1139
The acute effects of parathyroid hormone (PTH) on fibroblast growth factor 23 (FGF23) in vivo are not well understood. After a single subcutaneous PTH (1–34) injection (50 nmol/kg) in mice, FGF23 levels were assessed in plasma using assays that mea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93c55f4db623dfc51a0f2f7c0b36f99
https://doi.org/10.1210/en.2016-1451
https://doi.org/10.1210/en.2016-1451
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 370(3)
Opioids promote tumor angiogenesis in mammary malignancies, but the underlying signaling mechanism is largely unknown. The current study investigated the hypothesis that stimulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e40683fc20e55e305aa5d3f4f634a0df
https://pubmed.ncbi.nlm.nih.gov/31300611
https://pubmed.ncbi.nlm.nih.gov/31300611
Autor:
Fritz Aberger, Vanessa M. Knab, Sabrina Tripolt, Richard Moriggl, Heidi A. Neubauer, Daniela A. Fux, Dominik P. Elmer
The opioid crisis of pain medication bears risks from addiction to cancer progression, but little experimental facts exist. Expression of δ-opioid receptors (DORs) correlates with poor prognosis for breast cancer (BCa) patients, but mechanism and ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af088db8061566837b9ff9f1ffc70e1
https://doi.org/10.1101/443663
https://doi.org/10.1101/443663
