Targeting CD73 with flavonoids inhibits cancer stem cells and increases lymphocyte infiltration in a triple-negative breast cancer mouse model

Autor: Karan Mediratta, Sara El-Sahli, Marie Marotel, Muhammad Z. Awan, Melanie Kirkby, Ammar Salkini, Reem Kurdieh, Salman Abdisalam, Amit Shrestha, Chiara Di Censo, Andrew Sulaiman, Sarah McGarry, Jessie R. Lavoie, Zhen Liu, Seung-Hwan Lee, Xuguang Li, Giuseppe Sciumè, Vanessa M. D’Costa, Michele Ardolino, Lisheng Wang

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionChemotherapy remains the mainstay treatment for triple-negative breast cancer (TNBC) due to the lack of specific targets. Given a modest response of immune checkpoint inhibitors in TNBC patients, improving immunotherapy is an urgent and c

Externí odkaz: https://doaj.org/article/10213cd0c20d41adb4e2783bba54bf80

A triple-drug nanotherapy to target breast cancer cells, cancer stem cells, and tumor vasculature

Autor: Sara El-Sahli, Khang Hua, Andrew Sulaiman, Jason Chambers, Li Li, Eliya Farah, Sarah McGarry, Dan Liu, Peiyong Zheng, Seung-Hwan Lee, Jiefeng Cui, Marc Ekker, Marceline Côté, Tommy Alain, Xuguang Li, Vanessa M. D’Costa, Lisheng Wang, Suresh Gadde

Publikováno v: Cell Death and Disease, Vol 12, Iss 1, Pp 1-10 (2021)

Abstract Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, accounting for the majority of breast cancer-related death. Due to the lack of specific therapeutic targets, chemotherapeutic agents (e.g., paclitaxel) rem

Externí odkaz: https://doaj.org/article/01bd15f375e049938f736c0619b78c47

Salmonella effector sopd promotes plasma membrane scission by inhibiting rab10

Autor: Estelle M.N. Laurent, Etienne Coyaud, John H. Brumell, Miroslaw Cygler, Ksenia Beyrakhova, Kirsten C. Boddy, Vanessa M. D’Costa, Brian Raught, Sergio Grinstein, Hongxian Zhu, Jonathan St-Germain, Caishuang Xu

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, 2021, Nature Communications, 12, pp.4707. ⟨10.1038/s41467-021-24983-z⟩

Salmonella utilizes translocated virulence proteins (termed effectors) to promote host cell invasion. The effector SopD contributes to invasion by promoting scission of the plasma membrane, generating Salmonella-containing vacuoles. SopD is expressed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e74866a8e06f2ad4b7c11b9af86377b5
http://hdl.handle.net/20.500.12210/75053

BioID screen of Salmonella type 3 secreted effectors reveals host factors involved in vacuole positioning and stability during infection

Autor: Jonathan St-Germain, John H. Brumell, Estelle M.N. Laurent, Etienne Coyaud, Brian Raught, Kirsten C. Boddy, Vanessa M. D’Costa, Taoyingnan Li, Sergio Grinstein

Publikováno v: Nature microbiology. 4(12)

Many bacterial pathogens express virulence proteins that are translocated into host cells (herein referred to as effectors), where they can interact with target proteins to manipulate host cell processes. These effector-host protein interactions are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014c9bc5be8749d84d68cc56dfade315
https://pubmed.ncbi.nlm.nih.gov/31611645

Salmonella Disrupts Host Endocytic Trafficking by SopD2-Mediated Inhibition of Rab7

Autor: John H. Brumell, A. Proteau, Vanessa M. D'Costa, Sergio Grinstein, Laura McDonald, Rong Shi, Virginie Braun, Miroslaw Cygler, Marija Landekic

Publikováno v: Cell Reports, Vol 12, Iss 9, Pp 1508-1518 (2015)

SummaryIntracellular bacterial pathogens of a diverse nature share the ability to evade host immunity by impairing trafficking of endocytic cargo to lysosomes for degradation, a process that is poorly understood. Here, we show that the Salmonella ent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab4e10ca98f85da53cf156534cbe95a
http://www.sciencedirect.com/science/article/pii/S2211124715008530