Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Vanessa M Hayes"'
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0267714 (2022)
One of the most precise methods to detect prostate cancer is by evaluation of a stained biopsy by a pathologist under a microscope. Regions of the tissue are assessed and graded according to the observed histological pattern. However, this is not onl
Externí odkaz:
https://doaj.org/article/adcfa77d380d43c6b1bac65189ccf6c9
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0238108 (2020)
Somatic structural variants are an important contributor to cancer development and evolution. Accurate detection of these complex variants from whole genome sequencing data is influenced by a multitude of parameters. However, there are currently no t
Externí odkaz:
https://doaj.org/article/f240b8579fd543b6a92b58c635d335c2
Autor:
Ruotian Huang, M. S. Riana Bornman, Phillip D. Stricker, Ilma Simoni Brum, Shingai B. A. Mutambirwa, Weerachai Jaratlerdsiri, Vanessa M. Hayes
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The telomere repetitive TTAGGG motif at the ends of chromosomes, serves to preserve genomic integrity and chromosomal stability. In turn, genomic instability is a hallmark of cancer—implicating telomere disturbance. Prostate cancer (PCa) s
Externí odkaz:
https://doaj.org/article/2b418f8357d04c85b549cb09a2117576
Autor:
Eva K F Chan, Rae-Anne Hardie, Desiree C Petersen, Karen Beeson, Riana M S Bornman, Andrew B Smith, Vanessa M Hayes
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121223 (2015)
The oldest extant human maternal lineages include mitochondrial haplogroups L0d and L0k found in the southern African click-speaking forager peoples broadly classified as Khoesan. Profiling these early mitochondrial lineages allows for better underst
Externí odkaz:
https://doaj.org/article/b7f1241f57e24965b9f4553ee6453b5e
Autor:
Desiree C Petersen, Ondrej Libiger, Elizabeth A Tindall, Rae-Anne Hardie, Linda I Hannick, Richard H Glashoff, Mitali Mukerji, Indian Genome Variation Consortium, Pedro Fernandez, Wilfrid Haacke, Nicholas J Schork, Vanessa M Hayes
Publikováno v:
PLoS Genetics, Vol 9, Iss 3, p e1003309 (2013)
Within-population genetic diversity is greatest within Africa, while between-population genetic diversity is directly proportional to geographic distance. The most divergent contemporary human populations include the click-speaking forager peoples of
Externí odkaz:
https://doaj.org/article/f34cb3c61ec842318fcde1b3e737b630
Autor:
Pamela X. Y. Soh, Naledi Mmekwa, Desiree C. Petersen, Kazzem Gheybi, Smit van Zyl, Jue Jiang, Sean M. Patrick, Raymond Campbell, Weerachai Jaratlerdseri, Shingai B. A. Mutambirwa, M. S. Riana Bornman, Vanessa M. Hayes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract African ancestry is a significant risk factor for prostate cancer and advanced disease. Yet, genetic studies have largely been conducted outside the context of Sub-Saharan Africa, identifying 278 common risk variants contributing to a multie
Externí odkaz:
https://doaj.org/article/0adb9c46303d45be89fa67cea33e5123
Autor:
Darren N Saunders, Elizabeth A Tindall, Robert F Shearer, Jacquelyn Roberson, Amy Decker, Jean Amos Wilson, Vanessa M Hayes
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51762 (2012)
Mutations in the SERPINA1 gene can cause deficiency in the circulating serine protease inhibitor α(1)-Antitrypsin (α(1)AT). α(1)AT deficiency is the major contributor to pulmonary emphysema and liver disease in persons of European ancestry, with a
Externí odkaz:
https://doaj.org/article/0b47e6022f6f4bf98f0772d8b4a58e1d
Autor:
Kazzem Gheybi, Naledi Mmekwa, Maphuti Tebogo Lebelo, Sean M. Patrick, Raymond Campbell, Mukudeni Nenzhelele, Pamela X. Y. Soh, Muvhulawa Obida, Massimo Loda, Joyce Shirindi, Eboneé N. Butler, Shingai B. A. Mutambirwa, M. S. Riana Bornman, Vanessa M. Hayes
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Prostate cancer (PCa) is a significant health burden in Sub-Saharan Africa, with mortality rates loosely linked to African ancestry. Yet studies aimed at identifying contributing risk factors are lacking within the continent and as such excl
Externí odkaz:
https://doaj.org/article/d0fce8dd31414749a19a6f3cfa8336a2
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-25 (2023)
Abstract Background Using visual, biological, and electronic health records data as the sole input source, pretrained convolutional neural networks and conventional machine learning methods have been heavily employed for the identification of various
Externí odkaz:
https://doaj.org/article/07b74d23f28a472db760ff1b38bfeeac
Autor:
Vanessa M. Hayes, Tingting Gong, Shingai B. A. Mutambirwa, Weerachai Jaratlerdsiri, M. S. Riana Bornman
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 1, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/119e09ff03dc4943b19fd6bad3f01555