The genome of the African trypanosome Trypanosoma brucei

Autor: David W. Johnson, Barclay G. Barrell, Sharon Moule, Luke J. Tallon, Ian Goodhead, Lihua Hou, Jeremy Peterson, Danielle Walker, David M. A. Martin, Sara E. Melville, Kristine Jones, Martin Aslett, Appolinaire Djikeng, Neil Hall, Inna Cherevach, Hean Koo, Ester Rabbinowitsch, Steven L. Salzberg, Sarah Sharp, Mark Raymond Adams, Claire Arrowsmith, Andrew Barron, Elisabetta Ullu, Rebecca Atkin, Mark Simmonds, Al Ivens, John E. Donelson, Elodie Ghedin, P. Mooney, Adrian Tivey, Tamara Feldblyum, Audrey Fraser, Natasha Larke, Keith Gull, Jonathon Doggett, Doug Ormond, Jennifer R. Wortman, Claire M. Fraser, Carol Churcher, Mark Carrington, Chris P Reitter, Anjana J. Simpson, Joshua Shallom, Louise Clark, Brian J. Haas, Arnaud Kerhornou, Andrew Tait, Matthew Berriman, Mandy Sanders, Halina Norbertczak, Justin Johnson, Sally Whitehead, Jessica B. Hostetler, Scott M. Landfear, Frédéric Bringaud, Barbara Harris, Ann Cronin, J. David Barry, Fred R. Opperdoes, U. Cecilia M. Alsmark, Brian White, Craig Corton, John Woodward, Najib M. El-Sayed, Alexandra Line, Elisabet Caler, Annette MacLeod, Heidi Hauser, T. Martin Embley, Marie-Adèle Rajandream, Daniella Castanheira Bartholomeu, Mark C. Field, Angela Lord, Linda Hannick, C. Michael R. Turner, Gareth W. Morgan, Hubert Renauld, Bill Wickstead, Christiane Hertz-Fowler, Gaëlle Blandin, Shiliang Wang, Christopher S. Peacock, Tracey-Jane Chillingworth, Michael A. Quail, Karen Mungall, Robert L. Davies, Vanessa Leech, Alan H. Fairlamb, Susan Van Aken, Nicola Lennard, N. Hamlin, Ulrike Böhme, Karen Brooks, Owen White, Christopher Larkin, Lucio Marcello, Zahra Hance, David Harper, David Wanless, Grace Pai, Kay Jagels, Seth Schobel

African trypanosomes cause human sleeping sickness and livestock trypanosomiasis in sub-Saharan Africa. We present the sequence and analysis of the 11 megabase-sized chromosomes of Trypanosoma brucei . The 26-megabase genome contains 9068 predicted g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3750ef339c57c8ea7b18444005230de3
https://ora.ox.ac.uk/objects/uuid:68a73f00-8613-4389-bf92-d156df3b8386

Spontaneous dimerization and leucine-zipper induced activation of the recombinant catalytic domain of a new adenylyl cyclase of Trypanosoma brucei, GRESAG4.4B

Autor: Vanessa Leech, Thomas Seebeck, Rahel Schaub, Sara E. Melville, Christina Naula

Publikováno v: Molecular and Biochemical Parasitology. 112:19-28

In this study, we describe the isolation and characterization of a new adenylyl cyclase from Trypanosoma brucei and its activation by dimerization of the catalytic domain. In agreement with the current nomenclature of trypanosomal adenylyl cyclases,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49237c10bf4a15d1eec622ada032438d
https://doi.org/10.1016/s0166-6851(00)00338-8

The molecular karyotype of the megabase chromosomes of Trypanosoma brucei and the assignment of chromosome markers

Autor: Andrew Tait, Vanessa Leech, Jenefer M. Blackwell, Caroline S. Gerrard, Sara E. Melville

Publikováno v: Molecular and Biochemical Parasitology. 94:155-173

We present the molecular karyotype of the megabase chromosomes of Trypanosoma brucei stock TREU927/4 (927). We have identified 11 diploid chromosomes ranging in size from 1 to 5.2 Mb approximately and pairs of homologues differ in size by up to 15%.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c631646877fabe9ec778e408f6caeb
https://doi.org/10.1016/s0166-6851(98)00054-1

The sequence and analysis of Trypanosoma brucei chromosome II

Autor: Claire M. Fraser, Jinming Song, Samir Kaul, Sonya Taylor, Andrew Tait, Grace Pai, Shiguo Zhou, Elisabetta Ullu, Hanif Khalak, Steven L. Salzberg, Alison Tweedie, Tamara Feldblyum, Owen White, Nicolas Biteau, Frédéric Bringaud, David Wanless, Teresa Utterback, Anjana J. Simpson, Tanya Mason, Caroline S. Gerrard, Hean L. Koo, Mark Raymond Adams, C. Michael R. Turner, Christopher Larkin, Bernard B. Suh, David S. Schwartz, Susan Van Aken, Hong Zhao, Gaëlle Blandin, Lihua Hou, Linda Hannick, Elisabet Caler, Vanessa Leech, Sara E. Melville, Elodie Ghedin, Rong Qi, Annette MacLeod, Daniella Castanheira Bartholomeu, John E. Donelson, Brian J. Haas, Najib M. El-Sayed, Jeremy Peterson, Xiaoying Lin, Lowell Umayam

We report here the sequence of chromosome II from Trypanosoma brucei, the causative agent of African sleeping sickness. The 1.2-Mb pairs encode about 470 predicted genes organised in 17 directional clusters on either strand, the largest cluster of wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab2d57355dc6cae116208ed75bbe55a
https://europepmc.org/articles/PMC169936/

A New, Expressed Multigene Family Containing a Hot Spot for Insertion of Retroelements Is Associated with Polymorphic Subtelomeric Regions of Trypanosoma brucei

Autor: Matthew Berriman, Najib M. El-Sayed, Sara E. Melville, John E. Donelson, Nicolas Biteau, Vanessa Leech, Neil Hall, Stéphanie Hez, Théo Baltz, Frédéric Bringaud

Publikováno v: Eukaryotic Cell. 1:315-315

We describe a novel gene family that forms clusters in subtelomeric regions of Trypanosoma brucei chromosomes and partially accounts for the observed clustering of retrotransposons. The ingi and ribosomal inserted mobile element (RIME) non-LTR retrot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c662477c0ebf91bbc3dd70cf3590c1
https://doi.org/10.1128/ec.1.2.315-315.2002