RGMa and Neogenin control dendritic spine morphogenesis via WAVE Regulatory Complex-mediated actin remodeling

Autor: Kai Sempert, Belal Shohayeb, Vanessa Lanoue, Elizabeth A. O’Brien, Cecilia Flores, Helen M. Cooper

Publikováno v: Frontiers in Molecular Neuroscience, Vol 16 (2023)

Structural plasticity, the ability of dendritic spines to change their volume in response to synaptic stimulation, is an essential determinant of synaptic strength and long-term potentiation (LTP), the proposed cellular substrate for learning and mem

Externí odkaz: https://doaj.org/article/e2b3b46e3f444a3b8e5af93d1eda494f

Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG-Syt1-SV2 plasma membrane nanocluster for synaptic vesicle entry

Autor: Merja Joensuu, Parnayan Syed, Saber H Saber, Vanessa Lanoue, Tristan P Wallis, James Rae, Ailisa Blum, Rachel S Gormal, Christopher Small, Shanley Sanders, Anmin Jiang, Stefan Mahrhold, Nadja Krez, Michael A Cousin, Ruby Cooper‐White, Justin J Cooper‐White, Brett M Collins, Robert G Parton, Giuseppe Balistreri, Andreas Rummel, Frédéric A Meunier

Publikováno v: Joensuu, M, Syed, P, Saber, S H, Lanoue, V, Wallis, T P, Rae, J, Blum, A, Gormal, R S, Small, C, Sanders, S, Jiang, A, Mahrhold, S, Krez, N, Cousin, M A, Cooper-White, R, Cooper-White, J J, Collins, B M, Parton, R G, Balistreri, G, Rummel, A & Meunier, F A 2023, ' Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG-Syt1-SV2 plasma membrane nanocluster for synaptic vesicle entry ', EMBO Journal . https://doi.org/10.15252/embj.2022112095

The unique nerve terminal targeting of botulinum neurotoxin type A (BoNT/A) is due to its capacity to bind two receptors on the neuronal plasma membrane: polysialoganglioside (PSG) and synaptic vesicle glycoprotein 2 (SV2). Whether and how PSGs and S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bce58369df1764dd9ade86c6d436254
https://hdl.handle.net/20.500.11820/ba1259b2-1e41-40ca-b588-79326111cfdd

WNT5a Regulates Epithelial Morphogenesis in the Developing Choroid Plexus

Autor: Lenin Veeraval, Conor J. O’Leary, Michael B. Langford, Helen M. Cooper, Amanda White, Vanessa Lanoue

Publikováno v: Cerebral Cortex. 30:3617-3631

The choroid plexus (CP) is the predominant supplier of cerebral spinal fluid (CSF) and the site of the blood–CSF barrier and is thus essential for brain development and central nervous system homeostasis. Despite these crucial roles, our understand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9155582a90013704765d3c07d75ab0e5
https://doi.org/10.1093/cercor/bhz330

Radial contractility of actomyosin rings facilitates axonal trafficking and structural stability

Autor: Rumelo Amor, Wei Li, Jiang Anmin, Chunxia Liu, Frederic A. Meunier, Sally Martin, Merja Joensuu, Pranesh Padmanabhan, Vanessa Lanoue, Golnoosh Shamsollahi, Tong Wang, Andreas Papadopulos

Publikováno v: The Journal of Cell Biology

Wang et al. find that axonal radial contractility and local expansion control the retrograde trafficking of large cargoes. The periodic actomyosin-II network comprises NM-II filaments and F-actin rings. Loss of actomyosin-II–mediated radial contrac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf1ebebd023b41f3c5eba3c186b1f09
https://doi.org/10.1083/jcb.201902001

Excitatory/inhibitory balance of serotonergic axon connectivity in the brain

Autor: Arnauld Belmer, Omkar L. Patkar, Selena E. Bartlett, Vanessa Lanoue

Publikováno v: Journal of Neurology and Neuromedicine. 1:18-22

Serotonin neurons originate from the brainstem raphe nuclei and innervate the entire brain to regulate mood, emotion, sleep, appetite and aggression. Previous electron microscopy (EM) studies have revealed that 5-HT boutons directly contact several n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cffc9c0937da02621c3a40e2d57ee74d
https://doi.org/10.29245/2572.942x/2016/9.1079