Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks

Autor: Michael Walden, Michaela Schweizer, Anna T. Reinicke, Marlies Sachs, Kent E. Duncan, Vanessa Kraus, Fabio Morellini, Paul Saftig, Markus M. Rinschen, Karoline Laban, Julia Reichelt, Catherine Meyer-Schwesinger, Markus Damme, Wiebke Sachs, Philipp Christoph Janiesch

Publikováno v: Reinicke, A T, Laban, K, Sachs, M, Kraus, V, Walden, M, Damme, M, Sachs, W, Reichelt, J, Schweizer, M, Janiesch, P C, Duncan, K E, Saftig, P, Rinschen, M M, Morellini, F & Meyer-Schwesinger, C 2019, ' Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks ', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 16, pp. 7963-7972 . https://doi.org/10.1073/pnas.1812413116

Ubiquitin C-terminal hydrolase L1 (UCH-L1) is one of the most abundant and enigmatic enzymes of the CNS. Based on existing UCH-L1 knockout models, UCH-L1 is thought to be required for the maintenance of axonal integrity, but not for neuronal developm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8dead8e84ed985bad94f0e3fa98184
https://doi.org/10.1073/pnas.1812413116

The serine protease inhibitor neuroserpin is required for normal synaptic plasticity and regulates learning and social behavior

Autor: Chiara Nicolini, Rebecca Reumann, Lepu Zhou, Julia Mienert, Giovanna Galliciotti, Eva Viktoria Romswinkel, Fabio Morellini, Isidre Ferrer, Frederice Gries, Ricardo Vierk, Gabriele M. Rune, Vanessa Kraus, Markus Glatzel, Margaret Fahnestock

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname

The serine protease inhibitor neuroserpin regulates the activity of tissue-type plasminogen activator (tPA) in the nervous system. Neuroserpin expression is particularly prominent at late stages of neuronal development in most regions of the central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e778a39dcf7dadde921536d4a2703e64
https://doi.org/10.1101/lm.045864.117

Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice

Autor: Michaela Schweizer, Karl Jakob Vörckel, Vanessa Kraus, Mariya V. Hrynchak, Claudia Schob, Julia Calzada-Wack, Craig C. Garner, Irm Herrmans-Borgmeyer, Valerie Gailus-Durner, Martin Hrabě de Angelis, Henrike Hartung, Marco D. Brockmann, Hans-Jürgen Kreienkamp, Fabio Morellini, Ora Ohana, Helmut Fuchs, Dietmar Kuhl, Ileana L. Hanganu-Opatz, Nicole Cichon, Markus Wöhr, Sarah Scharf, Stefan Kindler, Roland Brandt, Lidia Bakota

Publikováno v: Translational Psychiatry 9(1), 7 (2019). doi:10.1038/s41398-018-0327-z
Translational Psychiatry
Translational Psychiatry, Vol 9, Iss 1, Pp 1-19 (2019)
Transl. Psychiatry 9:7 (2019)

In humans, genetic variants of DLGAP1-4 have been linked with neuropsychiatric conditions, including autism spectrum disorder (ASD). While these findings implicate the encoded postsynaptic proteins, SAPAP1-4, in the etiology of neuropsychiatric condi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f184752bc6898b5b9929d50dbb09d53
https://pub.dzne.de/record/140779

Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood

Autor: Christopher Käufer, Julie Sellau, Fabio Morellini, Stephanie Jansen, Ralf Bartenschlager, Ursula Müller, Melanie Richter, Lynn Schau, Robin Scharrenberg, Annette Preuß, Jonas Schmidt-Chanasit, Wolfgang Löscher, Stephanie Stanelle-Bertram, Helmut Fuchs, Sabine M. Hölter, Petra C. Arck, Oana V. Amarie, Vanessa Herder, Gülsah Gabriel, Vanessa M. Pfankuche, Carola Dreier, Froylan Calderon de Anda, Hanna Lotter, Ingo Gerhauser, Vanessa Kraus, Kerstin Walendy-Gnirß, Ronja Dörk, Gundula Pilnitz-Stolze, Olli Vapalahti, Martin Gabriel, Thais Moraes, Sany Benites, Stefan Hoenow, Daniel Cadar, Harald Ittrich, Benjamin Schattling, Swantje Thiele, Lane Rolling, Ivy Asantewaa Asante, Udo Bartsch, Stefanie Thanisch, Manuel A. Friese, Inken Waltl, Thomas Speiseder, Martin Hrabé de Angelis, Thomas Renné, Nancy Mounogou Kouassi, Wolfgang Baumgärtner

Publikováno v: Nat. Microbiol. 3, 1161–1174 (2018)

Congenital Zika virus (ZIKV) syndrome may cause fetal microcephaly in -1% of affected newborns. Here, we investigate whether the majority of clinically inapparent newborns might suffer from long-term health impairments not readily visible at birth. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e4130c8f20350b57f168985b301950
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=54254

Stimulation-related modifications of evolving functional brain networks in unresponsive wakefulness

Autor: Christoph Helmstaedter, Thorsten Rings, Lara Buscher, Benedikt Janssen, Sara Alaeddin, Vanessa Krause, Stefan Knecht, Klaus Lehnertz

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract Recent advances in neurophysiological brain network analysis have demonstrated novel potential for diagnosis and prognosis of disorders of consciousness. While most progress has been achieved on the population-sample level, time-economic and

Externí odkaz: https://doaj.org/article/4caf69dabe124f93ab350eeaa99d91aa