Differential effects of vagus nerve stimulation paradigms guide clinical development for Parkinson’s disease

Autor: Ariana Q. Farrand, Ryan S. Verner, Ryan M. McGuire, Kristi L. Helke, Vanessa K. Hinson, Heather A. Boger

Publikováno v: Brain Stimulation, Vol 13, Iss 5, Pp 1323-1332 (2020)

Background: Vagus nerve stimulation (VNS) modifies brain rhythms in the locus coeruleus (LC) via the solitary nucleus. Degeneration of the LC in Parkinson’s disease (PD) is an early catalyst of the spreading neurodegenerative process, suggesting th

Externí odkaz: https://doaj.org/article/4dc33fb2be944fd9b72fb41a25dafaa2

Differential effects of vagus nerve stimulation paradigms guide clinical development for Parkinson’s disease

Autor: Vanessa K. Hinson, Ariana Q. Farrand, Ryan M. McGuire, Heather A. Boger, Ryan S. Verner, Kristi L. Helke

Publikováno v: Brain Stimulation, Vol 13, Iss 5, Pp 1323-1332 (2020)

Background Vagus nerve stimulation (VNS) modifies brain rhythms in the locus coeruleus (LC) via the solitary nucleus. Degeneration of the LC in Parkinson’s disease (PD) is an early catalyst of the spreading neurodegenerative process, suggesting tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3adb5e8e9089cab587b2e1d05c8e678d
https://doi.org/10.1016/j.brs.2020.06.078

Effect of Urate-Elevating Inosine on Early Parkinson Disease Progression: The SURE-PD3 Randomized Clinical Trial

Autor: Tanya Simuni, Holly A. Shill, Matthew Brodsky, Marcie Rabin, Michael A. Schwarzschild, Kenneth Marek, Cheryl Waters, Cindy Casaceli, Steven A. Gunzler, Stephen G. Reich, Codrin Lungu, Sarah Elizabeth Zauber, Kellie Keith, Shyamal H. Mehta, Dariush Mozaffarian, Valerie Suski, Marie Saint-Hilaire, John L. Goudreau, Alice Rudolph, Ruth B. Schneider, Aaron Daley, Eric A. Macklin, Zoltan Mari, Grace F. Crotty, Andres Deik, Alberto J. Espay, Ashley Laroche, Sherri Mosovsky, Joohi Jimenez-Shahed, Mark S. LeDoux, Cynthia Poon, Ashley Gerald, John C. Morgan, Carolyn Peterson, Joseph H. Friedman, David Klements, Robert A. Hauser, Doozie Russell, David Simon, Kathrin LaFaver, Vanessa K. Hinson, Richard B. Dewey, Melissa Ainslie, Jason Aldred, Tiago A. Mestre, John Y. Fang, Liana S. Rosenthal, Grace Bwala, Raymond C. James, Binit B. Shah, Gearoid M. McMahon, Ariane Park, Rajeev Kumar, Lin Zhang, Ivan Bodis-Wollner, Mya C. Schiess, Katherine F. Callahan, David Oakes, Kelvin L. Chou, Melissa Kostrzebski, Roger Kurlan, Lisa Gauger, Albert Y. Hung, Melissa Bixby, Ira Shoulson, Michael Soileau, James T. Boyd, Peter A LeWitt, Burton L. Scott, Claire Henchcliffe, Patricia Kaminski, Alberto Ascherio, Cornelia Kamp, Lindsay Pothier, Anwar Ahmed, Jill Ciccarello, David J. Houghton, April Langhammer, Rebecca Fitzgerald, Maureen A. Leehey, Anthony E. Lang, Carmen Serrano, Martha McGraw, David Shprecher, Jennifer Durphy, Aleksandar Videnovic, Danish Bhatti, Christine Hunter, Amber Servi Ratel, J. Antonelle de Marcaida, Christopher G. Goetz, Emily Houston, Rajesh Pahwa, Chadwick W. Christine, Gary C. Curhan, Irene Litvan, Christopher A. Beck, Leslie J. Cloud, Patrick Bolger, Karen Thomas, Natividad Stover, Karen Blindauer, Sushrut S. Waikar, Susan R. Criswell

Publikováno v: JAMA

IMPORTANCE: Urate elevation, despite associations with crystallopathic, cardiovascular, and metabolic disorders, has been pursued as a potential disease-modifying strategy for Parkinson disease (PD) based on convergent biological, epidemiological, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4608ea519947a922d23da1991ccca9
https://europepmc.org/articles/PMC8441591/

Assessing Visuospatial Skills in Parkinson's: Comparison of Neuropsychological Assessment Battery Visual Discrimination to the Judgment of Line Orientation

Autor: Travis H. Turner, Jenna B. Renfroe, Vanessa K. Hinson

Publikováno v: Archives of Clinical Neuropsychology. 32:123-127

Objective Judgment of Line Orientation (JOLO) test is widely used in assessing visuospatial deficits in Parkinson's disease (PD). The neuropsychological assessment battery (NAB) offers the Visual Discrimination test, with age and education correction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1855d49f0e9c19a06a3c5126cde0831
https://doi.org/10.1093/arclin/acw102

Efficacy of Nilotinib in Patients With Moderately Advanced Parkinson Disease

Autor: Jaime Adams, Samuel Frank, Deborah Baker, Saurav Brahmachari, Elizabeth A. Klingner, Jason Aldred, Jennifer Mule, Meredith Spindler, Cornelia Kamp, Phounsavath Muneath, Claudia Rocha, Liana Baker, Gian Pal, Doozie Russell, Yvette Pitchford, Tina Ward, Olga Kishchenko, Kellie Keith, Angela S Stovall, Courtney Blair, John Slevin Slevin, Vanessa K. Hinson, Grace Bwala, Brian K. Fiske, Liana S. Rosenthal, Joohi Shahed, Andrew P. Duker, Patrick Bolger, Gary Rafaloff, David Weiner, Adolfo Ramirez-Zamora, Zoltan Mari, Renee Wagner Wagner, Helen Matthews, Karen Blindauer, Derek B. Ridgeway, Alexandria Oliver, Carlinda Field, Stephanie Burrows, Binit B. Shah, Lauren Seeberger, Charles S. Venuto, Katie Sullivan, Laura Ramirez, Erika F. Augustine, Matthew Swan, Lilliana Dumitrescu, Natividad Stover, Shonna Jenkins, Sharon Evans, Lin Zhang, Anwar Ahmed, Tanya Simuni, Michael A. Schwarzschild, Christopher S. Coffey, Mark S. LeDoux, David-Erick Lafontant, Laura Trusso, Farah Ismail, John L. Goudreau, Eric Molho, Sue Henderson, Cindy Casaceli, Christine Hunter, Holly Reynolds, Albert Y. Hung, Robert A. Hauser, Burton L. Scott, Lynn Wheeler, Kalpana Merchant, Chelsea Caspell-Garcia, Claire E. Wegel, Richard K. Wyse, Patrik Brundin, Christina Gruenwald, Alicia Brocht, Candace Cromer, Lisa Gauger, Melissa Bixby, Emily Carman, Kathryn A. Chung, Nichole McMullen, David Simon, Ken Eaton, Oren A. Levy, Amber Servi, Abigail Simpson, Holly A. Shill, Kelvin L. Chou, Melissa Kostrzebski, Ted M. Dawson

Publikováno v: JAMA Neurology. 78:312

Importance There is a critical need for careful and independent validation of reported symptomatic efficacy and dopaminergic biomarker changes induced by nilotinib in Parkinson disease (PD). Objectives To assess safety and tolerability of nilotinib i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8da5bef13be163263b4f128491abd097
https://doi.org/10.1001/jamaneurol.2020.4725