Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Vanessa J. O'Leary"'
Publikováno v:
Free Radical Biology and Medicine. 20:525-532
The enzyme 15-lipoxygenase has been implicated in the oxidation of low-density lipoprotein (LDL) in human atherosclerotic lesions. The biochemical mechanism for this oxidative process is not fully understood, and the interaction of the lipoxygenase-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd0a704499acf787b114835257ada20c
https://doi.org/10.1016/0891-5849(95)02084-5
https://doi.org/10.1016/0891-5849(95)02084-5
Publikováno v:
Free Radical Research. 25:181-192
The oxidative modification of low-density lipoprotein by macrophages may be an important mechanism in the pathogenesis of atherosclerosis. The human monocytic leukaemic cell line THP-1, when stimulated with phorbol ester, shares many properties with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dee638c800234e5edbc921d1601d8330
https://doi.org/10.3109/10715769609149923
https://doi.org/10.3109/10715769609149923
Autor:
Balaraman Kalyanaraman, Victor M. Darley-Usmar, Annette Graham, Vanessa J. O'Leary, Neil Hogg, Salvador Moncada
Publikováno v:
FEBS Letters. 330:181-185
Peroxynitrite is an oxidant which could be formed in the vasculature by the reaction of superoxide with nitric oxide. It is capable of modifying amino acid residues and of initiating lipid peroxidation. In the present study we have shown that peroxyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3457927d6a6b37b152b16e14ca25b54
https://doi.org/10.1016/0014-5793(93)80269-z
https://doi.org/10.1016/0014-5793(93)80269-z
Publikováno v:
Biochemical Pharmacology. 45:2195-2201
It is thought that the oxidation of low density lipoprotein (LDL) plays a key role in the pathogenesis of atherosclerosis. It is well known that lipid peroxidation reactions are propagated by peroxyl radicals and it follows, therefore, that the capac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20f1af3b5ebeb925d5f1bc0c46d3138
https://doi.org/10.1016/0006-2952(93)90189-4
https://doi.org/10.1016/0006-2952(93)90189-4
Publikováno v:
Pulmonary Pharmacology. 5:39-50
The effect of ozone (3 ppm, 15–120 min) on bronchial reactivity in the guinea-pig was studied. Ozone induced marked (6–250-fold) bronchial hyperreactivity (BHR) to a range of inhaled, but not intravenous bronchoconstrictors. The degree of BHR was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ecfb3f6e40fe6a462750707b4ebbdc0
https://doi.org/10.1016/0952-0600(92)90016-a
https://doi.org/10.1016/0952-0600(92)90016-a
Publikováno v:
Biochemical Journal. 278:163-169
The concentration-dependent effects of a series of lipoxygenase inhibitors and antioxidants on the macrophage-mediated oxidative modification of low-density lipoprotein (LDL) were measured. Their influence on macrophage 5-lipoxygenase pathway activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e99f986e07d8cadcac42551969ee8e3
https://doi.org/10.1042/bj2780163
https://doi.org/10.1042/bj2780163
Publikováno v:
Biochemical Society Transactions. 18:1064-1066
Copper-oxidized LDL has many of the characteristics of the modified LDL generated in the artery wall during the initial stages of atherosclerosis. It is not, however, a chemically defined species but shows significant variations in both its chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05da6d41ac8751ca49b74f4917d1b10
https://doi.org/10.1042/bst0181064
https://doi.org/10.1042/bst0181064
Autor:
Lorna C. Tilling, Victor M. Darley-Usmar, David J. Stone, Vanessa J. O'Leary, Gillian Fleetwood
Publikováno v:
Atherosclerosis. 119(2)
The measurement ex vivo of the resistance of low density lipoprotein (LDL) to oxidation promoted by copper is now being used in surveys of human populations at risk of developing atherosclerosis. However, it is not known whether a relationship betwee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a900c9b06d83c4cb7128e0f1ca14e7
https://pubmed.ncbi.nlm.nih.gov/8808494
https://pubmed.ncbi.nlm.nih.gov/8808494
Publikováno v:
The Biochemical journal. 282
It has been proposed that lipoxygenases, specifically 15-lipoxygenase, may play an important role in promoting the oxidation of low-density lipoprotein (LDL) in the artery wall. It is well known that peroxides are unstable in the presence of transiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3974c3b76790d344c70a8e7f59a42a
https://pubmed.ncbi.nlm.nih.gov/1554346
https://pubmed.ncbi.nlm.nih.gov/1554346
Publikováno v:
Free radical research communications. 17(1)
Oxidation of low density lipoprotein (LDL) has been shown to occur in the artery wall of atherosclerotic lesions in both animal models and human arteries. The oxidant(s) responsible for initiating this process are under intensive investigation and 15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c05256b5e668b0c343fdec80c330452
https://pubmed.ncbi.nlm.nih.gov/1332919
https://pubmed.ncbi.nlm.nih.gov/1332919