Výsledky vyhledávání - "Vanessa J. De-Paula"

Akademický článek

Antipsychotics preserve telomere length in peripheral blood mononuclear cells after acute oxidative stress injury

Autor: Gabriel B Polho, Giancarlo M Cardillo, Daniel S Kerr, Thais Chile, Wagner F Gattaz, Orestes V Forlenza, Helena P Brentani, Vanessa J De-Paula

Publikováno v: Neural Regeneration Research, Vol 17, Iss 5, Pp 1156-1160 (2022)

Antipsychotics may prolong or retain telomere length, affect mitochondrial function, and then affect the metabolism of nerve cells. To validate the hypothesis that antipsychotics can prolong telomere length after oxidative stress injury, leukocytes f

Externí odkaz: https://doaj.org/article/7a7653b4fd32439282a572ba74604eaf

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Acute and chronic lithium treatment increases Wnt/β-catenin transcripts in cortical and hippocampal tissue at therapeutic concentrations in mice

Autor: Jorge Kalil, Carla Cristine C. dos Santos, Orestes Vicente Forlenza, Vanessa J. De-Paula, Edecio Cunha-Neto, Taccyana M. Ali, Maria Carolina A. Luque

Publikováno v: Metabolic Brain Disease. 36:193-197

Lithium activates Wnt/β-catenin signaling leading to stabilization of free cytosolic β-catenin. The aim of the present study is to evaluate the in vivo effect of acute and chronic lithium treatment on the expression of β-catenin target genes, addr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c8c8d2704ae05b35440c38092238311
https://doi.org/10.1007/s11011-020-00638-8

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Acute and chronic lithium treatment increases Wnt/β-catenin transcripts in cortical and hippocampal tissue at therapeutic concentrations in mice

Autor: Vanessa J, De-Paula, Carla Cristine C, Dos Santos, Maria Carolina A, Luque, Taccyana M, Ali, Jorge E, Kalil, Orestes V, Forlenza, Edecio, Cunha-Neto

Publikováno v: Metabolic brain disease. 36(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b416187ea140b538a219c1f3a86aa964
https://pubmed.ncbi.nlm.nih.gov/33170418

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Relevance of gutmicrobiota in cognition, behaviour and Alzheimer’s disease

Autor: Orestes Vicente Forlenza, Vanessa J. De-Paula, Andrea S. Forlenza

Publikováno v: Pharmacological Research. 136:29-34

Approximately 95% of the symbiotic microbes in human body are located in the gut. This microbioma is involved in important homeostatic processes, not only related to gastrointestinal function but also to several complex modulatory processes, such as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38754a25f445abc87d7bcbbd2d66e871
https://doi.org/10.1016/j.phrs.2018.07.007

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Chronic Lithium Treatment Increases Telomere Length in Parietal Cortex and Hippocampus of Triple-Transgenic Alzheimer’s Disease Mice

Autor: Sergio Catanozi, Giancarlo de Mattos Cardillo, Wagner F. Gattaz, Vanessa J. De-Paula, Eliza Hiromi Ikenaga, Daniel S. Kerr, Orestes Vicente Forlenza, Evelin L. Schaeffer, Luciana Rodrigues Costa

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Telomere length (TL) is a biomarker of cell aging, and its shortening has been linked to several age-related diseases. In Alzheimer's disease (AD), telomere shortening has been associated with neuroinflammation and oxidative stress. The majority of s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f2b539e2fc33caf7cba9681591e776
https://doi.org/10.3233/jad-170838

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Long-term lithium treatment increases intracellular and extracellular brain-derived neurotrophic factor (BDNF) in cortical and hippocampal neurons at subtherapeutic concentrations

Autor: Vanessa J. De-Paula, Wagner F. Gattaz, Orestes Vicente Forlenza

Publikováno v: Bipolar Disorders. 18:692-695

Objectives The putative neuroprotective effects of lithium treatment rely on the fact that it modulates several homeostatic mechanisms involved in the neurotrophic response, autophagy, oxidative stress, inflammation, and mitochondrial function. Lithi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87576633fc159211c36c0c12492ecad9
https://doi.org/10.1111/bdi.12449

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Lithium Distinctly Modulates the Secretion of Pro- and Anti- Inflammatory Interleukins in Co-Cultures of Neurons and Glial Cells at Therapeutic and Sub-Therapeutic Concentrations

Autor: Gustavo Scola, Vanessa J. De-Paula, Orestes Vicente Forlenza, Daniel S. Kerr, Wagner F. Gattaz

Publikováno v: Current Alzheimer Research. 13:848-852

Lithium is associated with various effects on immune functions, some of which are still poorly understood. The roles of many cytokines have been characterized in a variety of neurodevelopmental processes including neurogenesis, neuronal and glial cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9720c254dba92421efa4caf71d1fb0e
https://doi.org/10.2174/1567205013666160219112612

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Long-Term Lithium Treatment Increases cPLA2 and iPLA2 Activity in Cultured Cortical and Hippocampal Neurons

Autor: Orestes Vicente Forlenza, Evelin L. Schaeffer, Leda Leme Talib, Wagner F. Gattaz, Daniel S. Kerr, Marília Palma Carvalho, Vanessa J. De-Paula

Publikováno v: Molecules, Vol 20, Iss 11, Pp 19878-19885 (2015)
Molecules; Volume 20; Issue 11; Pages: 19878-19885
Molecules
Volume 20
Issue 11
Pages 19878-19885

Background: Experimental evidence supports the neuroprotective properties of lithium, with implications for the treatment and prevention of dementia and other neurodegenerative disorders. Lithium modulates critical intracellular pathways related to n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f181cc5a09e259d8c260aaf5ab5c0aa9
http://www.mdpi.com/1420-3049/20/11/19663

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INTEGRATED ANALYSIS OF MICROARRAY AND PROTEOMICS DATA BY HIPPOCAMPAL RAT NEURONS AND HUMAN IPS NEURONS TREATED WITH DIFFERENT DOSES OF LITHIUM

Autor: Orestes Vicente Forlenza, Martin Schalling, Carlos Villaescusa, Helena Brentani, Vanessa J. De-Paula, Wagner F. Gattaz, Homero Vallada

Publikováno v: European Neuropsychopharmacology. 29:S898

Background Lithium salts have a well-established role in the treatment of psychiatric disorders as major affective disorders and more recently Alzheimer disease. Experimental and clinical studies have provided evidence that lithium may exert neuropro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e9144bb5acaa599f29d44f43228d8c28
https://doi.org/10.1016/j.euroneuro.2017.08.210

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Leukocyte telomere length in patients with schizophrenia: A meta-analysis

Autor: Vanessa J. De-Paula, Giancarlo de Mattos Cardillo, B. P. dos Santos, Gabriel Berlingieri Polho, Daniel S. Kerr

Publikováno v: Schizophrenia research. 165(2-3)

Schizophrenia has been suggested as a syndrome of accelerated aging. Telomere length (TL) decrease is considered one biological marker associated with age and can be accelerated by pathological characteristics present in schizophrenia. Several studie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4eeed90827ee415fbcd394e275af3a
https://pubmed.ncbi.nlm.nih.gov/25975826

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